Disease relevance of Radiation Leukemia Virus

• Cell lines induced in two mouse strains with RadLV produced by the C6VL/1 thymoma all specifically utilize common V alpha 3 and V beta 8.2 variable region genes in the formation of a TCR structure [1].
• The infectious complex of Abelson murine leukemia virus was altered by replacing its usual helper virus, Moloney leukemia virus, with radiation leukemia virus (RadLV) [2].
• Specifically, retrovirus integration has been monitored in clones derived from C1-V13D at the primary, secondary and tertiary passage through thymus using probes specific for long terminal repeat (LTR), gag, pol and env genes of RadLV [3].
• In vitro and in vivo antitumor effects of ketoconazole (KTZ), trifluoperazine (TFP), and combinations of both drugs were examined in cell lines established from radiation leukemia virus (RadLV)-induced T-cell lymphomas [4].

High impact information on Radiation Leukemia Virus

• We have analyzed the RNA genome of RadLV/VL3, a highly oncogenic murine leukemia virus [5].
• We conclude that p36 may represent a previously unrecognized transformation-related protein induced directly or indirectly by infection with RadLV [6].
• A single locus, tentatively denoted Srlv-1 (susceptibility to radiation leukemia virus [RadLV]-1), confers dominant susceptibility to RadLV-induced leukemogenesis [7].
• Significant levels of MuLV p30 and RadLV p12 were detected only in the thymuses [8].
• In addition, the levels of ATF-1 mRNA in uninfected and radiation leukemia virus-infected thymocytes parallel those of H-2Dd mRNA, and therefore, it is suggested that ATF-1 up-regulates the transcription of the H-2Dd gene after radiation leukemia virus infection of thymocytes [9].

Chemical compound and disease context of Radiation Leukemia Virus

• Rather, hypericin was found to be associated with RadLV particles, the retrovirions showed an increased density in sucrose, and the RadLV protein banding patterns were altered [10].
• The effect of dexamethasone (DXM) on the replication and titration assays of B-ecotropic radiation leukemia virus (RadLV-Rs) isolates was examined [11].

Biological context of Radiation Leukemia Virus

• Kinetics of propagation of B-tropic murine leukemia virus on Fv-1b cell lines: requirement for multiple cycles of cell replication for transformation and viral antigen expression by RadLV [12].

Anatomical context of Radiation Leukemia Virus

• In order to understand how PL cells are retained in the thymus for a prolonged period of time we determined whether RadLV infected cells secrete and/or respond to a T-cell growth factor that may be involved in the long-term maintenance of a thymic PL-cell pool [13].

Gene context of Radiation Leukemia Virus

• We found retroviral integrations in c-myc and Pim1 as already reported but we also identified for the first time Notch1 as a RadLV common integration site [14].
• In this article, we report not only the alteration of the Kis2 gene located nearby in response to RadLV integration but also the induction of the expression of Phf6, situated about 250 kbp from the integration site [14].
• A CD4- variant of C6VL/1 has now been isolated which also has RadLV binding capacity [15].
• We conclude that leukemia development due to RadLV infection is not associated with the reduction or disappearance of H-2D/H-2K gene products [16].
• Binding of cognate Radiation leukemia virus (RadLV) by the C6VL/1 thymoma involves a subset of TCR molecules in association with CD4 molecules expressed by that cell line [15].

References