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MeSH Review

Rhodnius

 
 
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Disease relevance of Rhodnius

 

High impact information on Rhodnius

  • High affinity histamine-binding and antihistaminic activity of the salivary nitric oxide-carrying heme protein (nitrophorin) of Rhodnius prolixus [2].
  • Because imidazole compounds such as histamine can interact with Fe(III) heme proteins, we investigated whether such substances could interact with Rhodnius nitrophorins [2].
  • This mechanism and Cimex nitrophorin structure are completely unlike those of the nitrophorins from Rhodnius prolixus, where NO protection is provided by a large conformational change that buries the heme nitrosyl complex, highlighting the remarkable evolution of proteins that assist insects in bloodfeeding [3].
  • Nitrophorin 2 (NP2) is a salivary lipocalin from Rhodnius prolixus that binds with coagulation factors IX (fIX) and IXa (fIXa) [4].
  • Nitrophorin 4 (NP4) is one of seven nitric oxide (NO) transporting proteins in the blood-sucking insect Rhodnius prolixus [5].
 

Biological context of Rhodnius

  • The effects of this anti-JH compound on molting and growth by Rhodnius prolixus and Triatoma dimidiata and reproduction in R. prolixus were tested and the efficacy of precocene II as a fumigant was assessed [6].
  • The spatiotemporal dynamics of transmembrane hydrogen ion (H+) fluxes during oogenesis were investigated in the telotrophic ovarioles of the insect, Rhodnius prolixus [7].
  • Protein kinase casein kinase II (CK II) activity was assayed during Rhodnius prolixus embryogenesis [8].
  • In this study we show that Vitellin (VT) phosphorylation in chorionated oocytes of Rhodnius prolixus is completely inhibited by heparin (10 microg/ml), a classical casein kinase II (CK II) inhibitor [9].
  • Thirteen such lipocalins are described in this review, with a particular focus on the heme-containing nitrophorins from Rhodnius prolixus, which transport nitric oxide, sequester histamine, and disrupt blood coagulation [10].
 

Anatomical context of Rhodnius

 

Associations of Rhodnius with chemical compounds

  • Urate synthesis in the blood-sucking insect rhodnius prolixus. Stimulation by hemin is mediated by protein kinase C [16].
  • Lysophosphatidylcholine acts as an anti-hemostatic molecule in the saliva of the blood-sucking bug Rhodnius prolixus [12].
  • 5-hydroxytryptamine-stimulated mitochondrial movement and microvillar growth in the lower malpighian tubule of the insect, Rhodnius prolixus [17].
  • During incubation in vivo, exogenously applied ionic lanthanum comes to surround the numerous neurosecretory terminals which are found lying within or immediately beneath the acellular neural lamella ensheathing the nerves from fifth instar and adult specimens of Rhodnius prolixus [18].
  • Purification and characterization of prolixin S (nitrophorin 2), the salivary anticoagulant of the blood-sucking bug Rhodnius prolixus [19].
 

Gene context of Rhodnius

  • All four Rhodnius nitrophorins transport NO and sequester histamine through heme binding, but only NP2 acts as an anticoagulant [20].
  • Previously, we utilized 4-iodopyrazole (4IPzH) as a heavy atom derivative for the initial solution of the crystal structure of the nitrophorin from Rhodnius prolixus, NP1, where it was found to bind to the heme with the iodo group disordered in two positions [21].
  • Rhodnius prolixus Malpighian tubule's aquaporin expression is modulated by 5-hydroxytryptamine [22].
  • The purpose of the present study was to detect the presence of an aquaporin-like water channel, a member of the major intrinsic protein (MIP) family, in the Malpighian tubule (MT) of the hematophagous insect Rhodnius prolixus, which excrete a large bulk of fluid after a massive blood meal, and its possible regulation by 5-hydroxytryptamine (5-HT) [22].
  • Rhodnius prolixus IPPRp exists as an isolated IPP domain which is secreted into the saliva of this blood-feeding insect [23].
 

Analytical, diagnostic and therapeutic context of Rhodnius

References

  1. Third instar nymphs of Rhodnius prolixus exposed to alpha-cyanopyrethroids: from hyperactivity to death. Alzogaray, R.A., Zerba, E.N. Arch. Insect Biochem. Physiol. (2001) [Pubmed]
  2. High affinity histamine-binding and antihistaminic activity of the salivary nitric oxide-carrying heme protein (nitrophorin) of Rhodnius prolixus. Ribeiro, J.M., Walker, F.A. J. Exp. Med. (1994) [Pubmed]
  3. Heme-assisted S-nitrosation of a proximal thiolate in a nitric oxide transport protein. Weichsel, A., Maes, E.M., Andersen, J.F., Valenzuela, J.G., Shokhireva, T.K.h., Walker, F.A., Montfort, W.R. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  4. Structural determinants of factor IX(a) binding in nitrophorin 2, a lipocalin inhibitor of the intrinsic coagulation pathway. Gudderra, N.P., Ribeiro, J.M., Andersen, J.F. J. Biol. Chem. (2005) [Pubmed]
  5. Structural dynamics controls nitric oxide affinity in nitrophorin 4. Nienhaus, K., Maes, E.M., Weichsel, A., Montfort, W.R., Nienhaus, G.U. J. Biol. Chem. (2004) [Pubmed]
  6. The effects of precocene II on reproduction and development of triatomine bugs (Reduviidae: Triatominae). Tarrant, C., Cupp, E.W., Bowers, W.S. Am. J. Trop. Med. Hyg. (1982) [Pubmed]
  7. Extracellular H+ dynamics during oogenesis in Rhodnius prolixus ovarioles. Bjornsson, C.S., Huebner, E. J. Exp. Biol. (2004) [Pubmed]
  8. Protein phosphorylation during Rhodnius prolixus embryogenesis: protein kinase casein kinase II activity. Fialho, E., Masuda, H., Silva-Neto, M.A. Insect Biochem. Mol. Biol. (1999) [Pubmed]
  9. Cyclic nucleotide-independent phosphorylation of vitellin by casein kinase II purified from Rhodnius prolixus oocytes. Silva-Neto, M.A., Fialho, E., Paes, M.C., Oliveira, P.L., Masuda, H. Insect Biochem. Mol. Biol. (2002) [Pubmed]
  10. Nitrophorins and related antihemostatic lipocalins from Rhodnius prolixus and other blood-sucking arthropods. Montfort, W.R., Weichsel, A., Andersen, J.F. Biochim. Biophys. Acta (2000) [Pubmed]
  11. A heme-binding protein from hemolymph and oocytes of the blood-sucking insect, Rhodnius prolixus. Isolation and characterization. Oliveira, P.L., Kawooya, J.K., Ribeiro, J.M., Meyer, T., Poorman, R., Alves, E.W., Walker, F.A., Machado, E.A., Nussenzveig, R.H., Padovan, G.J. J. Biol. Chem. (1995) [Pubmed]
  12. Lysophosphatidylcholine acts as an anti-hemostatic molecule in the saliva of the blood-sucking bug Rhodnius prolixus. Golodne, D.M., Monteiro, R.Q., Graca-Souza, A.V., Silva-Neto, M.A., Atella, G.C. J. Biol. Chem. (2003) [Pubmed]
  13. Induction of transport of organic anions in Malpighian tubules of Rhodnius. Maddrell, S.H., Gardiner, B.O. J. Exp. Biol. (1975) [Pubmed]
  14. Cytological evidence for serotonin-containing fibers in an abdominal neurohemal organ in a hemipteran. Flanagan, T.R. Brain Res. (1984) [Pubmed]
  15. The affinity of the lectins Ricinus communis and Glycine maxima to carbohydrates on the cell surface of various forms of Trypanosoma cruzi and Trypanosoma rangeli, and the application of these lectins for the identification of T. cruzi in the feces of Rhodnius prolixus. Marinkelle, C.J., Vallejo, G.A., Schottelius, J., Guhl, F., de Sanchez, N. Acta Trop. (1986) [Pubmed]
  16. Urate synthesis in the blood-sucking insect rhodnius prolixus. Stimulation by hemin is mediated by protein kinase C. Graça-Souza, A.V., Silva-Neto, M.A., Oliveira, P.L. J. Biol. Chem. (1999) [Pubmed]
  17. 5-hydroxytryptamine-stimulated mitochondrial movement and microvillar growth in the lower malpighian tubule of the insect, Rhodnius prolixus. Bradley, T.J., Satir, P. J. Cell. Sci. (1981) [Pubmed]
  18. Insect peripheral nerves: accessibility of neurohaemal regions to lanthanum. Lane, N.J., Leslie, R.A., Swales, L.S. J. Cell. Sci. (1975) [Pubmed]
  19. Purification and characterization of prolixin S (nitrophorin 2), the salivary anticoagulant of the blood-sucking bug Rhodnius prolixus. Ribeiro, J.M., Schneider, M., Guimarães, J.A. Biochem. J. (1995) [Pubmed]
  20. The crystal structure of nitrophorin 2. A trifunctional antihemostatic protein from the saliva of Rhodnius prolixus. Andersen, J.F., Montfort, W.R. J. Biol. Chem. (2000) [Pubmed]
  21. Axial ligand complexes of the Rhodnius nitrophorins: reduction potentials, binding constants, EPR spectra, and structures of the 4-iodopyrazole and imidazole complexes of NP4. Berry, R.E., Ding, X.D., Shokhireva, T.K.h., Weichsel, A., Montfort, W.R., Walker, F.A. J. Biol. Inorg. Chem. (2004) [Pubmed]
  22. Rhodnius prolixus Malpighian tubule's aquaporin expression is modulated by 5-hydroxytryptamine. Martini, S.V., Goldenberg, R.C., Fortes, F.S., Campos-de-Carvalho, A.C., Falkenstein, D., Morales, M.M. Arch. Insect Biochem. Physiol. (2004) [Pubmed]
  23. A secreted salivary inositol polyphosphate 5-phosphatase from a blood-feeding insect: allosteric activation by soluble phosphoinositides and phosphatidylserine. Andersen, J.F., Ribeiro, J.M. Biochemistry (2006) [Pubmed]
  24. Nitric oxide binding and crystallization of recombinant nitrophorin I, a nitric oxide transport protein from the blood-sucking bug Rhodnius prolixus. Andersen, J.F., Champagne, D.E., Weichsel, A., Ribeiro, J.M., Balfour, C.A., Dress, V., Montfort, W.R. Biochemistry (1997) [Pubmed]
  25. The biological activity of diuretic factors in Rhodnius prolixus. Te Brugge, V.A., Schooley, D.A., Orchard, I. Peptides (2002) [Pubmed]
  26. The distribution of a kinin-like peptide and its co-localization with a CRF-like peptide in the blood-feeding bug, Rhodnius prolixus. Te Brugge, V.A., Nässel, D.R., Coast, G.M., Schooley, D.A., Orchard, I. Peptides (2001) [Pubmed]
  27. Amplification of a specific repetitive DNA sequence for Trypanosoma rangeli identification and its potential application in epidemiological investigations. Vargas, N., Souto, R.P., Carranza, J.C., Vallejo, G.A., Zingales, B. Exp. Parasitol. (2000) [Pubmed]
 
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