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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Age Factors

 
 
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Disease relevance of Age Factors

  • However, the age factor is stronger than cadmium exposre in both polluted and control areas among persons without clinical proteinuria [1].
  • To identify responders when protein-bound polysaccharide (PSK) is used in adjuvant immunochemotherapy after curative resection of colorectal cancers, we examined the host and tumor factors that affect the prognosis incorporating the age factor [2].
  • In a series of 310 cases the role of the factors age, sex, location of the tumour (midline or lateral), and medulloblastoma type (classic or desmoplastic) were analysed with regard to the prognosis [3].
 

High impact information on Age Factors

  • These differential effects of GABA and the GABA antagonist on LHRH release in the two developmental stages were due to an age factor rather than to the steroid hormonal background [4].
  • Hemodynamic stress in hypertrophic cardiomyopathy, blood pressure changes: the age factor/the law of Laplace [5].
  • In both cohorts almost 3-fold higher median increases in urinary DHEAS excretion rates (P < 0.05) were observed during the 1-yr period of the individually highest rises in BMI compared with the 1-yr period of significantly lower rises in BMI (P < 0.01) in the same children after the factor age was controlled for [6].
  • We compared the level of expression with the well-established prognostic factors age, stage, histology, MYCN-amplification and TrkA expression, as well as outcome [7].
  • In this study, the authors investigated whether combined information on reproductive factors has additive value to the single reproductive factor age at menopause for assessing endogenous estrogen exposure and cardiovascular mortality risk in postmenopausal women [8].
 

Associations of Age Factors with chemical compounds

  • Duration of treatment had a small and statistically borderline effect (p less than 0.10) on theophylline clearance among nonasphyxiated infants when age factors were considered [9].
  • Age was the only factor to be significantly associated with coronary score and there was no significant association between coronary score and total LDL and HDL cholesterol or its subfractions when the age factor was taken into account [10].
  • The age factor explained part of the MAST and steroid hormone correlations with aggression [11].
  • A model regarded as clinically useful and which provided a good fit to both the population from which it was derived and the test population included the pretreatment factors age, history of an antecedent hematologic disorder, temperature, blood urea nitrogen, hemoglobin, and liver size [12].
  • On multivariate analysis (including era of treatment), 3 factors-age > 60 years, lactate dehydrogenase > normal, and omission of methotrexate-were associated significantly with poorer OS (hazard ratio: 2.3, 2.2, and 2.3, respectively) [13].
 

Gene context of Age Factors

  • CONCLUSION: The study demonstrates for the first time that (1) CD34 is heterogeneously expressed by human pulmonary EC, and (2) the physiological/pathophysiological factors age/PH influence CD34 expression [14].
  • It was found that the level of ER correlated with the age factors and the menstrual status [15].
  • Radiation inhibition of mdx mouse muscle regeneration: dose and age factors [16].
  • Prognostic significance of the age factor in the thyroid cancer: statistical analysis [17].
  • In an analysis of covariance with the continuous factors age, office SBP and the categorical factor antihypertensive treatment, 24-h SBP was higher in PAD patients compared to controls (P < 0.05) [18].

References

  1. Increased urinary beta 2-microglobulin in cadmium exposure: dose-effect relationship and biological significance of beta 2-microglobulin. Tsuchiya, K., Iwao, S., Sugita, M., Sakurai, H. Environ. Health Perspect. (1979) [Pubmed]
  2. Significance of postoperative adjuvant immunochemotherapy after curative resection of colorectal cancers: identification of responders incorporating the age factor. Munemoto, Y., Iida, Y., Ohata, K., Saito, H., Fujisawa, K., Kasahara, Y., Mitsui, T., Asada, Y., Miura, S. Oncol. Rep. (2004) [Pubmed]
  3. Medulloblastoma: survey of factors possibly influencing the prognosis. Müller, W., Afra, D., Schröder, R., Slowik, F., Wilcke, O., Klug, N. Acta neurochirurgica. (1982) [Pubmed]
  4. gamma-Aminobutyric acid is an inhibitory neurotransmitter restricting the release of luteinizing hormone-releasing hormone before the onset of puberty. Mitsushima, D., Hei, D.L., Terasawa, E. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  5. Hemodynamic stress in hypertrophic cardiomyopathy, blood pressure changes: the age factor/the law of Laplace. Bittar, G. Circulation (1991) [Pubmed]
  6. Role of nutritional status in the regulation of adrenarche. Remer, T., Manz, F. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  7. Expression of Apo-3 and Apo-3L in primitive neuroectodermal tumours of the central and peripheral nervous system. Eggert, A., Grotzer, M.A., Zuzak, T.J., Ikegaki, N., Zhao, H., Brodeur, G.M. Eur. J. Cancer (2002) [Pubmed]
  8. Endogenous estrogen exposure and cardiovascular mortality risk in postmenopausal women. de Kleijn, M.J., van der Schouw, Y.T., Verbeek, A.L., Peeters, P.H., Banga, J.D., van der Graaf, Y. Am. J. Epidemiol. (2002) [Pubmed]
  9. Factors influencing theophylline disposition in 179 newborns. Gilman, J.T., Gal, P., Levine, R.S., Hersh, C.B., Erkan, N.V. Therapeutic drug monitoring. (1986) [Pubmed]
  10. Relation of angiographically defined coronary artery disease to serum lipoprotein levels. O'Sullivan, J.J., Matthew, A., Conroy, R.M., Erwin, R.J., Duggan, P.F. Clinical cardiology. (1990) [Pubmed]
  11. Testosterone, 5 alpha-dihydrotestosterone and cortisol in men with and without alcohol-related aggression. von der, P.B., Sarkola, T., Seppa, K., Eriksson, C.J. J. Stud. Alcohol (2002) [Pubmed]
  12. Prediction of remission in adult acute leukemia: development and testing of predictive models. Smith, T.L., Gehan, E.A., Keating, M.J., Freireich, E.J. Cancer (1982) [Pubmed]
  13. The treatment of primary central nervous system lymphoma in 122 immunocompetent patients: a population-based study of successively treated cohorts from the British Colombia Cancer Agency. Shenkier, T.N., Voss, N., Chhanabhai, M., Fairey, R., Gascoyne, R.D., Hoskins, P., Klasa, R., Morris, J., O'Reilly, S.E., Pickles, T., Sehn, L., Connors, J.M. Cancer (2005) [Pubmed]
  14. Expression of CD34 in pulmonary endothelial cells in vivo. Müller, A.M., Nesslinger, M., Skipka, G., Müller, K.M. Pathobiology (2002) [Pubmed]
  15. Study of the role of steroid receptors in human breast cancer. Tsyrlina, E.V., Semiglazov, V.P., Moiseenko, V.M., Bornoeva, T.P. Neoplasma (1985) [Pubmed]
  16. Radiation inhibition of mdx mouse muscle regeneration: dose and age factors. Quinlan, J.G., Lyden, S.P., Cambier, D.M., Johnson, S.R., Michaels, S.E., Denman, D.L. Muscle Nerve (1995) [Pubmed]
  17. Prognostic significance of the age factor in the thyroid cancer: statistical analysis. Falvo, L., Catania, A., Sorrenti, S., D'Andrea, V., Berni, A., Stefano, M.D., Antoni, E.D. Journal of surgical oncology. (2004) [Pubmed]
  18. Office blood pressure underestimates ambulatory blood pressure in peripheral arterial disease in comparison to healthy controls. Svensson, P., de Faire, U., Niklasson, U., Ostergren, J. Journal of human hypertension. (2004) [Pubmed]
 
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