Disease relevance of Radicular Cyst

• Odontogenic keratocyst fragments in explant culture secreted a larger amount of IL-1alpha than dentigerous cyst and radicular cyst fragments in explant culture, and spontaneously secreted both proMMP-9 and an active form of MMP-9 [1].
• End-point assays indicated that the linings of odontogenic keratocysts contained higher levels of glucose-6-phosphate dehydrogenases (p < 0.0002) and lower levels of lactate dehydrogenase (p < 0.002) than those of radicular cysts [2].
• The cystic epithelial cells of odontogenic cystic lesions (keratocyst 60%; primordial cyst 75%; radicular cyst 35%; and follicular cyst 47.4%) were positive to EGFR staining [3].
• Thus the expression of HSP27 was investigated immunohistochemically in periapical granulomas with epithelial rests of Malassez and in radicular cysts [4].
• An immunoperoxidase method was used to detect involucrin in 47 odontogenic tumors and 35 radicular cysts [5].

High impact information on Radicular Cyst

• Levels of GM-CSF, IL-3, and IL-6 in fluid and tissue from human radicular cysts [6].
• Cytokeratin expression patterns for distinction of odontogenic keratocysts from dentigerous and radicular cysts [7].
• The purpose of this study was to investigate the in situ localization of tissue-type PA (t-PA) and type I PA inhibitor (PAI-1) in radicular cysts [8].
• Immunohistochemical localization of tissue-type plasminogen activator and type I plasminogen activator inhibitor in radicular cysts [8].
• Moreover, significantly greater t-PA as well as PAI-1 expression was noted in radicular cysts with high levels of inflammation as compared to tissues with low levels of inflammatory cell infiltrates (P < 0.05) [8].

Chemical compound and disease context of Radicular Cyst

• In tissue sections the highest amount of tryptase-positive staining was observed in radicular cysts (mean 6.2% of reference area) and the lowest amount in keratocysts (mean 2.1% of reference area, P < 0.01) [9].
• In addition, another section from each radicular cyst specimen was stained with hematoxylin and eosin to assess the presence of inflammatory infiltrates [8].
• By contrast, succinate dehydrogenase activity was significantly higher in radicular cyst linings (p < 0.03) [2].
• The distribution of subunit A of Factor XIII (FXIIIa) and of collagenous components was investigated by the avidin-biotin-peroxidase complex (ABC) method for FXIIIa and by the Sirius red F3BA method, respectively, in 43 cases of radicular cysts [10].
• 3. Anti-human apo B antibody inhibited cholesterol-binding activity in radicular cyst fluid [11].

Biological context of Radicular Cyst

• Loss of heterozygosity (LOH) for the D9S287 marker and/or D9S180 marker was observed in about 50% of dentigerous cysts, whereas radicular cysts gave no indication of lesions in the PTCH region [12].

Anatomical context of Radicular Cyst

• 1. Josamycin concentrations in cyst wall (wall) and cyst fluid (fluid) of radicular cyst and serum following a single oral administration of josamycin (600 mg) were assayed by a paper disk method [13].
• It is considered that fibroblasts around radicular cysts may lead to high IL-6 synthesis over time in chronic inflammation [14].
• The objective of this investigation was to determine the immunohistochemical pattern of expression of mast cells tryptase in periapical lesions based on study of 20 apical granulomas and 20 periapical cysts [15].
• We examined the IL-1 beta production in human dental pulp (HDP) cells treated with lipopolysaccharide (LPS) from Porphyromonas endodontalis (P. e.) isolated from root canals and radicular cyst fluids [16].
• On the other hand, epithelial cells always were stained by VEGF/VPF antibody, both in periapical lesions with epithelium and in radicular cysts [17].

Gene context of Radicular Cyst

• This study demonstrated the wide expression of mRNA encoding inflammatory cytokines in radicular cyst tissues, and RCC itself was capable of stimulating IL-6 and IL-8 production from HGFs [18].
• No difference was observed between MDM2 expression in radicular cyst and adenomatoid odontogenic tumour [19].
• While we found no reason to believe that PTCH should be associated with radicular cysts, other genes may be implicated in their development [12].
• Results here support the hypothesis that MMP-1 may play an important role in the expansion of radicular cysts [20].
• Immunohistochemical localization of cyclooxygenase-2 in radicular cysts [21].

Analytical, diagnostic and therapeutic context of Radicular Cyst

• The expression of mRNA encoding the inflammatory cytokines interleukin-1alpha (IL-1alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor alpha(TNF-alpha) have been examined in radicular cysts by in situ hybridization [18].
• Josamycin concentrations in radicular cysts following a single oral administration [13].
• Immunoassays demonstrated the presence of IL-1 alpha and -6 in all fluids and explants tested; IL-1 beta was only found in the inflammatory radicular cysts [22].

References