The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Arteritis Virus, Equine

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Arteritis Virus, Equine

 

High impact information on Arteritis Virus, Equine

  • We now show that the N-terminal replicase subunit, nonstructural protein 1 (nsp1), of the nidovirus equine arteritis virus is in fact dispensable for replication but crucial for transcription, thereby coupling replicase expression and subgenomic mRNA synthesis in an unprecedented manner [5].
  • Intra- and intermolecular disulfide bonds of the GP2b glycoprotein of equine arteritis virus: relevance for virus assembly and infectivity [6].
  • Using an equine arteritis virus (EAV) infectious cDNA clone, we have analyzed the requirement for GP(5)-M heterodimerization and have identified the Cys residues involved in the formation of the GP(5)-M disulfide bond [7].
  • The 5' end of the equine arteritis virus replicase gene encodes a papainlike cysteine protease [8].
  • Equine arteritis virus non-structural protein 1, an essential factor for viral subgenomic mRNA synthesis, interacts with the cellular transcription co-factor p100 [9].
 

Chemical compound and disease context of Arteritis Virus, Equine

  • The small envelope glycoprotein (GS) of equine arteritis virus folds into three distinct monomers and a disulfide-linked dimer [1].
  • Sequence comparison revealed that the equine arteritis virus PCP alpha counterpart probably was inactivated by loss of its catalytic Cys residue [10].
  • Immunoperoxidase histochemistry as a diagnostic tool for detection of equine arteritis virus antigen in formalin fixed tissues [11].
  • Skin biopsies were collected from the affected areas, and serial sections were evaluated following hematoxylin and eosin and immunoperoxidase histochemistry staining by using a murine monoclonal antibody of the immunoglobulin G2A isotype recognizing the 30-kDa membrane protein of equine arteritis virus (EAV) [12].
  • Venereal infection with equine arteritis virus (EAV) was established in each of seven mares by inoculation via the cervix with 20 ml of viral suspension (> or = 8 x 10(6) plaque-forming units; PFU), following treatment with prostaglandin and oestradiol [13].
 

Biological context of Arteritis Virus, Equine

 

Gene context of Arteritis Virus, Equine

 

Analytical, diagnostic and therapeutic context of Arteritis Virus, Equine

References

  1. The small envelope glycoprotein (GS) of equine arteritis virus folds into three distinct monomers and a disulfide-linked dimer. de Vries, A.A., Raamsman, M.J., van Dijk, H.A., Horzinek, M.C., Rottier, P.J. J. Virol. (1995) [Pubmed]
  2. Open reading frame 1a-encoded subunits of the arterivirus replicase induce endoplasmic reticulum-derived double-membrane vesicles which carry the viral replication complex. Pedersen, K.W., van der Meer, Y., Roos, N., Snijder, E.J. J. Virol. (1999) [Pubmed]
  3. Construction of chimeric arteriviruses reveals that the ectodomain of the major glycoprotein is not the main determinant of equine arteritis virus tropism in cell culture. Dobbe, J.C., van der Meer, Y., Spaan, W.J., Snijder, E.J. Virology (2001) [Pubmed]
  4. A replication-competent chimera of plant and animal viruses. Peng, C.W., Peremyslov, V.V., Snijder, E.J., Dolja, V.V. Virology (2002) [Pubmed]
  5. A zinc finger-containing papain-like protease couples subgenomic mRNA synthesis to genome translation in a positive-stranded RNA virus. Tijms, M.A., van Dinten, L.C., Gorbalenya, A.E., Snijder, E.J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  6. Intra- and intermolecular disulfide bonds of the GP2b glycoprotein of equine arteritis virus: relevance for virus assembly and infectivity. Wieringa, R., De Vries, A.A., Post, S.M., Rottier, P.J. J. Virol. (2003) [Pubmed]
  7. Heterodimerization of the two major envelope proteins is essential for arterivirus infectivity. Snijder, E.J., Dobbe, J.C., Spaan, W.J. J. Virol. (2003) [Pubmed]
  8. The 5' end of the equine arteritis virus replicase gene encodes a papainlike cysteine protease. Snijder, E.J., Wassenaar, A.L., Spaan, W.J. J. Virol. (1992) [Pubmed]
  9. Equine arteritis virus non-structural protein 1, an essential factor for viral subgenomic mRNA synthesis, interacts with the cellular transcription co-factor p100. Tijms, M.A., Snijder, E.J. J. Gen. Virol. (2003) [Pubmed]
  10. Processing and evolution of the N-terminal region of the arterivirus replicase ORF1a protein: identification of two papainlike cysteine proteases. den Boon, J.A., Faaberg, K.S., Meulenberg, J.J., Wassenaar, A.L., Plagemann, P.G., Gorbalenya, A.E., Snijder, E.J. J. Virol. (1995) [Pubmed]
  11. Immunoperoxidase histochemistry as a diagnostic tool for detection of equine arteritis virus antigen in formalin fixed tissues. Lopez, J.W., del Piero, F., Glaser, A., Finazzi, M. Equine Vet. J. (1996) [Pubmed]
  12. Diagnosis of equine arteritis virus infection in two horses by using monoclonal antibody immunoperoxidase histochemistry on skin biopsies. Del Piero, F. Vet. Pathol. (2000) [Pubmed]
  13. Venereal infection of mares by equine arteritis virus and use of killed vaccine against the infection. Fukunaga, Y., Wada, R., Imagawa, H., Kanemaru, T. J. Comp. Pathol. (1997) [Pubmed]
  14. Characterization of the neutralization determinants of equine arteritis virus using recombinant chimeric viruses and site-specific mutagenesis of an infectious cDNA clone. Balasuriya, U.B., Dobbe, J.C., Heidner, H.W., Smalley, V.L., Navarrette, A., Snijder, E.J., MacLachlan, N.J. Virology (2004) [Pubmed]
  15. Effect of heparin on hemagglutination by equine arteritis virus. Sano, Y., Inaba, Y., Uwatoko, K., Kubota, T., Asagoe, T., Kanaya, J., Pan, I.J., Akashi, H., Fukunaga, Y. J. Vet. Med. Sci. (1998) [Pubmed]
  16. Monoclonal antibodies to equine arteritis virus proteins identify the GL protein as a target for virus neutralization. Deregt, D., de Vries, A.A., Raamsman, M.J., Elmgren, L.D., Rottier, P.J. J. Gen. Virol. (1994) [Pubmed]
  17. Lactate dehydrogenase-elevating virus (LDV): subgenomic mRNAs, mRNA leader and comparison of 3'-terminal sequences of two LDV isolates. Kuo, L., Chen, Z., Rowland, R.R., Faaberg, K.S., Plagemann, P.G. Virus Res. (1992) [Pubmed]
  18. Lelystad virus belongs to a new virus family, comprising lactate dehydrogenase-elevating virus, equine arteritis virus, and simian hemorrhagic fever virus. Meulenberg, J.J., Hulst, M.M., de Meijer, E.J., Moonen, P.L., den Besten, A., de Kluyver, E.P., Wensvoort, G., Moormann, R.J. Arch. Virol. Suppl. (1994) [Pubmed]
  19. Detection of antibodies to equine arteritis virus by a monoclonal antibody-based blocking ELISA. Cho, H.J., Entz, S.C., Deregt, D., Jordan, L.T., Timoney, P.J., McCollum, W.H. Can. J. Vet. Res. (2000) [Pubmed]
 
WikiGenes - Universities