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Disease relevance of Scabies


High impact information on Scabies


Chemical compound and disease context of Scabies

  • Sulfiram, a drug applied topically to treat scabies, produces effects similar to those of disulfiram after subsequent ingestion of ethanol [10].
  • The development of aerial mycelia in S. alboniger, S. scabies, and S. coelicolor was also sensitive to glucose repression [11].
  • In both sexes, scabies was commoner in smokers (P <0.05) and parenteral drug abusers (P <0.001) [12].
  • All S. alboniger, 27% of S. scabies, and 39% of the S. violaceus-ruber Amy- isolates were arginine auxotrophs [13].
  • We found that both benzyl benzoate and ivermectin alone were quite effective in mild to moderate scabies, but they were both associated with an unacceptable rate of relapse and failure in severe or crusted scabies [2].

Biological context of Scabies


Anatomical context of Scabies


Gene context of Scabies

  • The lack of IL-4 but high levels of IL-10 suggests that IL-10 was likely secreted by type 1 T-regulatory cells, which were activated by something in the scabies extract [19].
  • No IL-2 or IL-4 was produced in response to scabies extract [19].
  • Sixty patients with scabies were typed for thirty-three antigens of the HLA-A, -B and -C series [20].
  • Previous studies suggested that the balance between the Th1 and Th2 immune responses may influence the outcome of a scabies infestation in a sensitized host [17].
  • One major observation of this literature search is that permethrin is the treatment of choice for lice and scabies in the US and in Great Britain, whereas lindane is still recommended for scabies in most other European countries because of its longer-standing record of effectiveness [21].

Analytical, diagnostic and therapeutic context of Scabies


  1. Tropical rat mite dermatitis: case report and review. Engel, P.M., Welzel, J., Maass, M., Schramm, U., Wolff, H.H. Clin. Infect. Dis. (1998) [Pubmed]
  2. Ivermectin alone or in combination with benzyl benzoate in the treatment of human immunodeficiency virus-associated scabies. Alberici, F., Pagani, L., Ratti, G., Viale, P. Br. J. Dermatol. (2000) [Pubmed]
  3. Biosynthesis of indole-3-acetic acid via the indole-3-acetamide pathway in Streptomyces spp. Manulis, S., Shafrir, H., Epstein, E., Lichter, A., Barash, I. Microbiology (Reading, Engl.) (1994) [Pubmed]
  4. Lindane neurotoxic reaction in nonbullous congenital ichthyosiform erythroderma. Friedman, S.J. Archives of dermatology. (1987) [Pubmed]
  5. Comparative study of 5% permethrin cream and 1% lindane lotion for the treatment of scabies. Schultz, M.W., Gomez, M., Hansen, R.C., Mills, J., Menter, A., Rodgers, H., Judson, F.N., Mertz, G., Handsfield, H.H. Archives of dermatology. (1990) [Pubmed]
  6. Lindane for scabies in Bangladesh. Codington, H.B., Coghlan, S.E. Lancet (1993) [Pubmed]
  7. Community control of scabies: a model based on use of permethrin cream. Taplin, D., Porcelain, S.L., Meinking, T.L., Athey, R.L., Chen, J.A., Castillero, P.M., Sanchez, R. Lancet (1991) [Pubmed]
  8. Nitrofurazone in scabies. Chowdhurry, S.P. Lancet (1977) [Pubmed]
  9. Scabies mimicking systemic lupus erythematosus. Bastian, H.M., Lindgren, A.M., Alarcón, G.S. Am. J. Med. (1997) [Pubmed]
  10. Photolysis of sulfiram: a mechanism for its disulfiram-like reaction. Mays, D.C., Nelson, A.N., Benson, L.M., Johnson, K.L., Naylor, S., Lipsky, J.J. Biochem. Pharmacol. (1994) [Pubmed]
  11. Control of differentiation in streptomycetes: involvement of extrachromosomal deoxyribonucleic acid and glucose repression in aerial mycelia development. Redshaw, P.A., McCann, P.A., Sankaran, L., Pogell, B.M. J. Bacteriol. (1976) [Pubmed]
  12. Sarcoptes scabiei in a sexually transmitted infections unit: a 15-year study. Otero, L., Varela, J.A., Espinosa, E., Sánchez, C., Junquera, M.L., del Valle, A., Vázquez, F. Sexually transmitted diseases. (2004) [Pubmed]
  13. Simultaneous loss of multiple differentiated functions in aerial mycelium-negative isolates of streptomycetes. Redshaw, P.A., McCann, P.A., Pentella, M.A., Pogell, B.M. J. Bacteriol. (1979) [Pubmed]
  14. Percutaneous absorption of DDT from a parasiticide used for treatment of scabies. Kolmodin-Hedman, B., Borglund, E., Werner, Y. Acta Derm. Venereol. (1979) [Pubmed]
  15. Comparative percutaneous absorption of lindane and permethrin. Franz, T.J., Lehman, P.A., Franz, S.F., Guin, J.D. Archives of dermatology. (1996) [Pubmed]
  16. Modulation of cytokine expression in human keratinocytes and fibroblasts by extracts of scabies mites. Arlian, L.G., Morgan, M.S., Neal, J.S. Am. J. Trop. Med. Hyg. (2003) [Pubmed]
  17. Skewed Th1/Th2 immune response to Sarcoptes scabiei. Lalli, P.N., Morgan, M.S., Arlian, L.G. J. Parasitol. (2004) [Pubmed]
  18. Influence of sarcoptic mange and cold and ambient temperature on blastogenic responses of lymphocytes and serum cortisol concentrations of pigs. Wooten-Saadi, E., Blecha, F., Stevenson, J.S., Broce, A.B. Am. J. Vet. Res. (1988) [Pubmed]
  19. Evidence that scabies mites (Acari: Sarcoptidae) influence production of interleukin-10 and the function of T-regulatory cells (Tr1) in humans. Arlian, L.G., Morgan, M.S., Paul, C.C. J. Med. Entomol. (2006) [Pubmed]
  20. HLA antigens in patients with scabies. Falk, E.S., Thorsby, E. Br. J. Dermatol. (1981) [Pubmed]
  21. Pharmacotherapy of ectoparasitic infections. Roos, T.C., Alam, M., Roos, S., Merk, H.F., Bickers, D.R. Drugs (2001) [Pubmed]
  22. Dermatoimmunopathology of scabies. Hoefling, K.K., Schroeter, A.L. J. Am. Acad. Dermatol. (1980) [Pubmed]
  23. Atypical scabies in HIV-positive patients. Portu, J.J., Santamaria, J.M., Zubero, Z., Almeida-Llamas, M.V., Aldamiz-Etxebarria San Sebastian, M., Gutiérrez, A.R. J. Am. Acad. Dermatol. (1996) [Pubmed]
  24. Atopy patch test reactions to house dust mites in patients with scabies. Taşkapan, O., Harmanyeri, Y. Acta Derm. Venereol. (2005) [Pubmed]
  25. Treatment of scabies with disulfiram and benzyl benzoate emulsion: a controlled study. Landegren, J., Borglund, E., Storgårds, K. Acta Derm. Venereol. (1979) [Pubmed]
  26. Crusted scabies in a healthy infant. Baysal, V., Yildirim, M., Türkman, C., Aridogan, B., Aydin, G. Journal of the European Academy of Dermatology and Venereology : JEADV. (2004) [Pubmed]
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