Disease relevance of Osteoma

• RFB MuLV induced osteomas, osteopetrosis, and lymphomas in newborn NMRI mice [1].
• Another CF-1 mouse-derived leukemia virus, FBJ MuLV, the helper virus of the FBJ osteosarcoma virus stock, as well as Akv, also induced osteomas, osteopetrosis, and lymphomas in NMRI mice similar to RFB MuLV [1].
• Extra-colonic manifestations also occur in FAP and include desmoid tumors, epidermoid cysts and osteomas [2].
• Gardner syndrome, a phenotypic variant of familial adenomatous polyposis, is characterized by the classical clinical triad of skin and soft tissue tumours, osteomas and intestinal polyposis, but disease patterns with pairs of these findings have also been reported [3].
• Gardner syndrome is a variant of FAP, in which the patients also develop extraintestinal tumors, in particular osteomas and desmoid tumors [4].

High impact information on Osteoma

• During the course of a long-term oral study in OF-1 mice for the assessment of any carcinogenic potential of the immunosuppressive agent cyclosporine (CS-A), a high incidence of osteomas was found in all treatment groups as well as in controls [5].
• GNAS1 mutation and Cbfa1 misexpression in a child with severe congenital platelike osteoma cutis [6].
• Association of choroidal osteoma with retinitis pigmentosa is reported [7].
• Treatment of multiple miliary osteoma cutis with tretinoin gel [8].
• Erbium: YAG laser ablation of osteoma cutis: modifications of the approach [9].

Chemical compound and disease context of Osteoma

• Pigmentation of osteoma cutis caused by tetracycline [10].
• Pigmented postacne osteoma cutis in a patient treated with minocycline: report and review of the literature [11].
• RESULTS: Late-phase fluorescein angiograms allow assessment of the extension of the osteoma as it is variably hyperfluorescent due to tumor staining combined with a variable degree of overlying retinal pigment epithelial changes [12].
• Techniques are described for the evaluation of osteomas, including the use of coronal and axial plane computed tomography [13].
• Osteoma cutis: a case of probable exacerbation following treatment of severe acne with isotretinoin [14].

Biological context of Osteoma

• This suggests that tetracycline, combined with new bone formation, causes pigmentation of osteoma cutis [10].

Anatomical context of Osteoma

• The results thus indicate that in osteoma cutis, fibroblasts have the ability to differentiate into osteoblastic cells, which have some properties of osteoblasts, such as high alkaline phosphatase activity and a high expression of osteonectin [15].
• These observations suggest that the sclerotic bone shell characteristic of osteoid osteomas may be an inductive reaction of host bed tissue to an osteoma cell product that is comparable to bone morphogenetic protein (BMP) produced by normal bone cells and transferred by normal bone matrix [16].

Gene context of Osteoma

• This was confirmed by demonstrating high alkaline phosphatase activity and osteonectin expression in osteoma cutis lesions [15].
• We present an interesting case of BPPV following an otherwise uneventful neurosurgical removal of a parietal osteoma using hammer and chisel [17].
• An N-ecotropic murine leukemia virus (OA MuLV), originally isolated from spontaneous osteomas of strain 101 mice, was molecularly cloned [18].
• Multiple papules on the elbows. Congenital osteoma cutis [19].
• The results also indicate a potential pathophysiologic role in patients with heterozygous inactivating mutations in GNAS1, the gene for the alpha chain (Gsalpha) of the heterotrimeric G protein, present in three disorders with ectopic intramembranous bone: Albright's hereditary osteodystrophy, progressive osseous heteroplasia, and osteoma cutis [20].

Analytical, diagnostic and therapeutic context of Osteoma

• Intraocular lesions such as amelanotic melanoma, metastatic tumor, choroidal osteoma, disciform scar, serous detachment, and central serous chorioretinopathy can appear similar to circumscribed choroidal hemangioma (CCH) on ophthalmoscopy, but may be differentially diagnosed with fluorescein angiography, ultrasonography, and periodic observation [21].

References