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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Osteoma


High impact information on Osteoma

  • During the course of a long-term oral study in OF-1 mice for the assessment of any carcinogenic potential of the immunosuppressive agent cyclosporine (CS-A), a high incidence of osteomas was found in all treatment groups as well as in controls [5].
  • GNAS1 mutation and Cbfa1 misexpression in a child with severe congenital platelike osteoma cutis [6].
  • Association of choroidal osteoma with retinitis pigmentosa is reported [7].
  • Treatment of multiple miliary osteoma cutis with tretinoin gel [8].
  • Erbium: YAG laser ablation of osteoma cutis: modifications of the approach [9].

Chemical compound and disease context of Osteoma

  • Pigmentation of osteoma cutis caused by tetracycline [10].
  • Pigmented postacne osteoma cutis in a patient treated with minocycline: report and review of the literature [11].
  • RESULTS: Late-phase fluorescein angiograms allow assessment of the extension of the osteoma as it is variably hyperfluorescent due to tumor staining combined with a variable degree of overlying retinal pigment epithelial changes [12].
  • Techniques are described for the evaluation of osteomas, including the use of coronal and axial plane computed tomography [13].
  • Osteoma cutis: a case of probable exacerbation following treatment of severe acne with isotretinoin [14].

Biological context of Osteoma


Anatomical context of Osteoma

  • The results thus indicate that in osteoma cutis, fibroblasts have the ability to differentiate into osteoblastic cells, which have some properties of osteoblasts, such as high alkaline phosphatase activity and a high expression of osteonectin [15].
  • These observations suggest that the sclerotic bone shell characteristic of osteoid osteomas may be an inductive reaction of host bed tissue to an osteoma cell product that is comparable to bone morphogenetic protein (BMP) produced by normal bone cells and transferred by normal bone matrix [16].

Gene context of Osteoma

  • This was confirmed by demonstrating high alkaline phosphatase activity and osteonectin expression in osteoma cutis lesions [15].
  • We present an interesting case of BPPV following an otherwise uneventful neurosurgical removal of a parietal osteoma using hammer and chisel [17].
  • An N-ecotropic murine leukemia virus (OA MuLV), originally isolated from spontaneous osteomas of strain 101 mice, was molecularly cloned [18].
  • Multiple papules on the elbows. Congenital osteoma cutis [19].
  • The results also indicate a potential pathophysiologic role in patients with heterozygous inactivating mutations in GNAS1, the gene for the alpha chain (Gsalpha) of the heterotrimeric G protein, present in three disorders with ectopic intramembranous bone: Albright's hereditary osteodystrophy, progressive osseous heteroplasia, and osteoma cutis [20].

Analytical, diagnostic and therapeutic context of Osteoma


  1. Molecular and pathogenic characterization of the RFB osteoma virus: lack of oncogene and induction of osteoma, osteopetrosis, and lymphoma. Gimbel, W., Schmidt, J., Brack-Werner, R., Luz, A., Strauss, P.G., Erfle, V., Werner, T. Virology (1996) [Pubmed]
  2. Association of extracolonic manifestations of familial adenomatous polyposis with acetylation phenotype in a large FAP kindred. Scott, R.J., Taeschner, W., Heinimann, K., Müller, H., Dobbie, Z., Morgenthaler, S., Hoffmann, F., Peterli, B., Meyer, U.A. Eur. J. Hum. Genet. (1997) [Pubmed]
  3. The concomitant occurrence of multiple epidermal cysts, osteomas and thyroid gland nodules is not diagnostic for Gardner syndrome in the absence of intestinal polyposis: a clinical and genetic report. Herrmann, S.M., Adler, Y.D., Schmidt-Petersen, K., Nicaud, V., Morrison, C., Paul, M., Zouboulis, C.h.C. Br. J. Dermatol. (2003) [Pubmed]
  4. Novel germline APC mutations in Swedish patients with familial adenomatous polyposis and Gardner syndrome. Nilbert, M., Fernebro, J., Kristoffersson, U. Scand. J. Gastroenterol. (2000) [Pubmed]
  5. Osteomas in OF-1 mice: no alteration in biologic behavior during long-term treatment with cyclosporine. Wilson, J.T., Hauser, R.E., Ryffel, B. J. Natl. Cancer Inst. (1985) [Pubmed]
  6. GNAS1 mutation and Cbfa1 misexpression in a child with severe congenital platelike osteoma cutis. Yeh, G.L., Mathur, S., Wivel, A., Li, M., Gannon, F.H., Ulied, A., Audi, L., Olmstead, E.A., Kaplan, F.S., Shore, E.M. J. Bone Miner. Res. (2000) [Pubmed]
  7. Choroidal osteoma: observations from a community setting. Browning, D.J. Ophthalmology (2003) [Pubmed]
  8. Treatment of multiple miliary osteoma cutis with tretinoin gel. Smith, C.G., Glaser, D.A. J. Am. Acad. Dermatol. (1999) [Pubmed]
  9. Erbium: YAG laser ablation of osteoma cutis: modifications of the approach. Ochsendorf, F.R., Kaufmann, R. Archives of dermatology. (1999) [Pubmed]
  10. Pigmentation of osteoma cutis caused by tetracycline. Walter, J.F., Macknet, K.D. Archives of dermatology. (1979) [Pubmed]
  11. Pigmented postacne osteoma cutis in a patient treated with minocycline: report and review of the literature. Moritz, D.L., Elewski, B. J. Am. Acad. Dermatol. (1991) [Pubmed]
  12. Indocyanine green angiography in choroidal osteoma. Lafaut, B.A., Mestdagh, C., Kohno, T., Gaudric, A., De Laey, J.J. Graefes Arch. Clin. Exp. Ophthalmol. (1997) [Pubmed]
  13. Osteomas of the orbit. Grove, A.S. Ophthalmic surgery. (1978) [Pubmed]
  14. Osteoma cutis: a case of probable exacerbation following treatment of severe acne with isotretinoin. Brodkin, R.H., Abbey, A.A. Dermatologica (1985) [Pubmed]
  15. A study of bone formation in osteoma cutis employing biochemical, histochemical and in situ hybridization techniques. Oikarinen, A., Tuomi, M.L., Kallionen, M., Sandberg, M., Väänänen, K. Acta Derm. Venereol. (1992) [Pubmed]
  16. Growth of osteoid osteoma transplanted into athymic nude mice. Urist, M.R., Lindholm, T.S., Mirra, J.M., Grant, T.T., Finerman, G.A. Clin. Orthop. Relat. Res. (1979) [Pubmed]
  17. An unusual cause of benign paroxysmal positional vertigo. Andaz, C., Whittet, H.B., Ludman, H. The Journal of laryngology and otology. (1993) [Pubmed]
  18. Oncogenic retrovirus from spontaneous murine osteomas. II. Molecular cloning and genomic characterization. Leib-Mösch, C., Schmidt, J., Etzerodt, M., Pedersen, F.S., Hehlmann, R., Erfle, V. Virology (1986) [Pubmed]
  19. Multiple papules on the elbows. Congenital osteoma cutis. Mast, A.M., Hansen, R. Archives of dermatology. (1997) [Pubmed]
  20. Reduction in Gsalpha induces osteogenic differentiation in human mesenchymal stem cells. Lietman, S.A., Ding, C., Cooke, D.W., Levine, M.A. Clin. Orthop. Relat. Res. (2005) [Pubmed]
  21. Circumscribed choroidal hemangioma. Nguyen, A.T., Anderson, S.F., Townsend, J.C. Journal of the American Optometric Association. (1995) [Pubmed]
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