Disease relevance of Furunculosis

• Community-onset methicillin-resistant Staphylococcus aureus associated with antibiotic use and the cytotoxin Panton-Valentine leukocidin during a furunculosis outbreak in rural Alaska [1].
• The response of Atlantic salmon, Salmo salar, to infection by the bacterial pathogen Aeromonas salmonicida (the causative agent of furunculosis), was investigated using a cohabitation model and a custom Atlantic salmon cDNA microarray consisting of over 4000 different amplicons [2].
• Resistance rates to erythromycin in patients with furunculosis and impetigo were 51.5% and 26.2%, respectively (p less than 0.001) [3].
• In a family with recurrent staphylococcal disease presenting as furunculosis or carbuncles, an association with mannose-binding lectin deficiency was investigated [4].
• A 60-year-old HIV-negative man with known noninsulin-dependent diabetes mellitus and glucose 6-phosphate-dehydrogenase deficiency anemia suffered from chronic recurrent furunculosis since the age of 30 [5].

High impact information on Furunculosis

• Vitamin C for the treatment of recurrent furunculosis in patients with imparied neutrophil functions [6].
• Furunculosis associated with repeated courses of omeprazole therapy [7].
• Association of furunculosis and familial deficiency of mannose-binding lectin [4].
• The protection elicited by a kanamycin-resistant aroA mutant of A. salmonicida (Brivax I) and an unmarked aroA deletion mutant (Brivax II) has been examined, and data compared with protection seen using a freeze-dried Brivax II preparation and a commercial, oil-adjuvanted killed vaccine for furunculosis [8].
• In spite of the smaller increase in S. aureus colonization in the mupirocin-treated group no difference was demonstrated in either the incidence of specific S. aureus infections (e.g. furunculosis) or the prevalence of isotretinoin-related inflammatory side-effects [9].

Chemical compound and disease context of Furunculosis

• The effect of vitamin C treatment on 23 patients with a history of recurrent furunculosis with negative nasal cultures was studied [6].
• Rainbow trout, Atlantic salmon and brown trout, respectively, exhibit an increasing order of susceptibility to furunculosis [10].
• There is also the possibility that certain bacteriologic features associated with erythromycin resistance may foster the development of furunculosis [3].
• Evaluation of once daily treatment with cyclosporine for anal furunculosis in dogs [11].
• Intractable chronic furunculosis: prevention of recurrences with pentoxifylline [5].

Biological context of Furunculosis

• Therefore, patients suffering from recurrent furunculosis with defective neutrophil functions may be treated successfully with vitamin C, contributing to both neutrophil function recovery and a dramatic clinical response [6].
• CONCLUSION: Members of a particular family suffering from furunculosis differ from their 'healthy' relatives as to mannose-binding lectin genotypes, indicating the relevance of normal mannose-binding lectin levels in the defence against staphylococcal disease [4].
• Efficacy of orally administered oxolinic acid and Vetoquinol, an oxolinic acid ester, for the treatment of furunculosis in Atlantic salmon Salmo salar held in seawater [12].

Gene context of Furunculosis

• Increased expression of mRNA for IL-1beta, IL-6, tumour necrosis factor alpha, IL-8, IL-10 and transforming growth factor beta1 was detected in the biopsies from the lesions of anal furunculosis relative to the control tissues (P < 0.05) [13].
• Among predictor variables independently associated with MRSA infection, the strongest was infection type being furuncle (odds ratio 28.6) [14].
• It is proposed that trout alpha 2M may have a defensive function against furunculosis but the resistance of the bacterial protease to inhibition by the majority of the serum protease inhibitors may represent pathogenic adaptation [15].
• The results indicate that furunculosis patients do not have a defective serological response against S. aureus beta hemolysin [16].
• A pre-existing cutaneous furuncle was the only identifiable cause [17].

Analytical, diagnostic and therapeutic context of Furunculosis

• The effectiveness of the delivery of amoxicillin to Atlantic salmon, undergoing chemotherapy in natural outbreaks of furunculosis in sea-cages, was investigated by measuring the concentration of the drug in serum samples [18].
• Parr of Atlantic salmon (Salmo salar) were given intraperitoneal injections of either a commercial, monovalent furunculosis vaccine (Apoject) or live, attenuated A. salmonicida (DeltaaroA) [19].

References