Disease relevance of Southwestern United States

• We have performed molecular genetic analyses of Hispanic individuals with cystic fibrosis (CF) in the southwestern United States. Of 129 CF chromosomes analyzed, only 46% (59/129) carry delta F508 [1].
• The 1993 outbreak of hantavirus pulmonary syndrome (HPS) in the southwestern United States was associated with Sin Nombre virus, a rodent-borne hantavirus; The virus' primary reservoir is the deer mouse (Peromyscus maniculatus) [2].
• Recent studies have resulted in the proposal of a new species, Aeromonas schubertii (mannitol, sucrose, and indole negative), formerly termed Enteric Group 501, on the basis of the study of seven strains isolated from the southeastern and southwestern United States and Puerto Rico [3].
• Investigation of a recent outbreak of acute respiratory illness in the southwestern United States resulted in the recognition of a new disease, hantavirus pulmonary syndrome (HPS) with high mortality [4].
• We report the case of a 40-year-old man who developed life-threatening angioedema and hypotension following the bite of a Gila monster (Heloderma suspectum), a venomous lizard of the southwestern United States. He recovered after treatment with IV fluids, epinephrine, antihistamines, and corticosteroids [5].

High impact information on Southwestern United States

• Columnar stalagmites in caves of the Guadalupe Mountains during the late Holocene record a 4000-year annually resolved climate history for the southwestern United States. Annual banding, hiatuses, and high-precision uranium-series dating show a present day-like climate from 4000 to 3000 years ago, following a drier middle Holocene [6].
• In contrast, in 91 unrelated non-Ashkenazic persons with BS whom we examined, blmAsh was identified only in 5, these coming from Spanish-speaking Christian families from the southwestern United States, Mexico, or El Salvador [7].
• Clinical features of hepatitis C-infected patients with persistently normal alanine transaminase levels in the Southwestern United States [8].
• The accuracy of personal histories as a means of excluding smokers was examined prospectively in three phase I units in the northeastern, midwestern, and southwestern United States. In studies intended for nonsmokers, 45 of 282 purported nonsmokers screened before enrollment tested positive for cotinine [9].
• Application of a sensitive new detection method has revealed widespread perchlorate contamination of groundwater in the southwestern United States, typically at 0.005-0.020 mg/L (5-20 ppb) [10].

Chemical compound and disease context of Southwestern United States

• This is similar to the HIV infection rates reported for nonpregnant parenteral drug-using populations in other areas of the southwestern United States, suggesting that there may be a lower rate of endemic infection in this region of the country [11].

Biological context of Southwestern United States

• Perchlorate anion (ClO4-) has been found in drinking water supplies throughout the southwestern United States. It is primarily associated with releases of ammonium perchlorate by defense contractors, military operations, and aerospace programs [12].

Associations of Southwestern United States with chemical compounds

• Bile acid composition of some lizards from southwestern United States [13].
• CONCLUSIONS: Voluntary use of flunitrazepam is becoming a health concern to sexually active young women who reside in the southwestern United States. Young women who have used LSD or marijuana in the past or who have a peer or partner who used this drug appear to be at the greatest risk [14].
• The hallucinogen mescaline is found in the peyote and San Pedro cacti, which are prevalent in Mexico and the southwestern United States. In a survey of middle-class, predominantly white adolescents in a drug treatment facility, 18 percent of the respondents indicated that they had taken mescaline [15].
• College students from a large university in the southwestern United States were queried using the 134-item Armstrong Team Tattoo Attitude Survey. Findings documents a progressive increase in tattooing and reflect significant support for tattoos, even from non-tattooed students [16].
• The primary product extracted from this common plant of the arid regions of northern Mexico and Southwestern United States is the potent antioxidant nordihydroguaiaretic acid (NDGA) [17].

Gene context of Southwestern United States

• Estimating recharge distribution by incorporating runoff from mountainous areas in an alluvial basin in the Great Basin region of the southwestern United States [18].
• SETTING: Community setting in the southwestern United States. PARTICIPANTS: Convenience sample of 113 women with physician-confirmed MS (mean age, 45.79y) [19].
• SETTING: Large tertiary care center in the southwestern United States. SAMPLE: 28 patients with cancer in two groups: traditional home health and home health plus telenursing [20].

References