Disease relevance of Pregnancy, Prolonged

• Cortisol values obtained were compared with those of 1) gravidas with prolonged pregnancy (greater than 42 weeks) who delivered post-mature neonates (N=6), 2) gravidas in spontaneous term labor (N = 10), and 3) gravidas in premature labor (N=10) [1].
• The purpose of this study was to determine if both the placenta and umbilical vessels are possible sites of atrial natriuretic peptide metabolism and to evaluate the effects that labor, route of delivery, prolonged pregnancy, preeclampsia, and fetal distress have on umbilical arterial atrial natriuretic peptide levels [2].
• To overcome dystocia, commonly associated with fetal oversize in prolonged pregnancies, parturition was induced with one of three agents: betamethasone, cloprostenol or dinoprost [3].

High impact information on Pregnancy, Prolonged

• Intact animals and rats with control lesions receiving an infusion of relaxin had significantly (P < 0.05) prolonged pregnancies compared with intact saline-infused controls [4].
• In contrast, progesterone treatment prolonged pregnancy beyond day 25 and attenuated the decline in RGS2 messenger RNA levels [5].
• Simultaneous application of aminoguanidine and nimesulide significantly (P =.008) prolonged pregnancy to a degree similar to nimesulide alone [6].
• OBJECTIVE: To compare the effect of mifepristone with placebo on cervical ripening before labor induction in prolonged pregnancies [7].
• In prolonged-pregnancy rats, BrdU incorporation also continued to decrease as observed in normal-pregnancy rats after day 15, and then no enhancement in B-cell proliferation was observed even when the plasma lactogenic activity, including re-secreted PL-I, reached maximum [8].

Chemical compound and disease context of Pregnancy, Prolonged

• Foetal and maternal cortisol and progesterone and maternal oestradiol in prolonged pregnancy after foetal hypophysectomy in sheep [9].
• These findings suggested that labor could be initiated in prolonged pregnancy by iatrogenic elevation of fetal plasma cortisol [10].
• On the contrary, long-term dexamethasone administration is associated with prolonged pregnancy and suppression of estrogen biosynthesis [11].
• Confirming the clinical impression that the cervix is seldom favorable in prolonged pregnancy, the initial Bishop score was only 3.6, and in only 8.2% was the score 7 or more [12].
• Fetoplacental steroid metabolism in prolonged pregnancies [13].

Biological context of Pregnancy, Prolonged

• Progesterone, injected into pregnant rats on the last days of pregnancy, prolonged pregnancy and prevented parturition [14].
• Consistent with a PGF2 alpha antagonistic mechanism of action, DIPA treatment throughout gestation prolonged pregnancy to the upper normal limit [15].
• The activity of N-acetyl-beta-hexosaminidase was found to be significantly higher in the placentas collected after delivery from women in puerperium with symptoms of prolonged pregnancy or complicated by EPH gestosis, than in placentas from normal pregnancy [16].

Anatomical context of Pregnancy, Prolonged

• Amniotic fluid squalene: a useful test in prolonged pregnancy [17].
• Indomethacin administration in late pregnancy prolonged gestation in caged rhesus monkeys and inhibited premature labour and postponed delivery in chronically catheterized monkey fetuses [18].

Gene context of Pregnancy, Prolonged

• Labor, route of delivery, and prolonged pregnancy had no effect on umbilical arterial atrial natriuretic peptide levels [2].
• The results suggest that even in prolonged pregnancies VAST and CST might be released from routine supervision [19].
• Fetal fibronectin in vaginal fluid of women in prolonged pregnancy [20].
• We have investigated the secretory patterns of three placental lactogens (PL-alpha, PL-beta and placental lactogen-II) during normal pregnancy and in two prolonged-pregnancy models [21].

References