The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Adenoviruses, Human

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Adenoviruses, Human


High impact information on Adenoviruses, Human


Chemical compound and disease context of Adenoviruses, Human

  • Similar repeating units were detected in hamster cells that were nonpermissive for human adenovirus and in cells pretreated with n-butyrate [11].
  • Types I and II cyclic adenosine 3':5'-monophosphate (cAMP)-dependent protein kinases were compared in extracts from untransformed rat 3Y1 cells and 3Y1 cells transformed by the highly oncogenic human adenovirus type 12 [12].
  • A highly efficient receptor-mediated delivery system for DNA and oligodeoxynucleotides (ODNs) to avian liver cells has been established, using complexes of nonmodified human adenovirus particles and a protein conjugate consisting of N-acetyl-glucosamine-modified bovine serum albumin, streptavidin, and Poly-L-lysine [13].
  • One proposed mechanisms to explain human adenovirus persistence is an ineffective CTL response due to reduced cell surface expression of class I MHC Ag on virally infected cells, an effect mediated by the 19-kDa glycoprotein encoded by Ad early region 3 (E3) [14].
  • The inhibitory profile of the isolated proteinase and the affinity labeling clearly indicate that the human adenovirus type 2 proteinase is a cysteine rather than a serine proteinase as previously believed [5].

Biological context of Adenoviruses, Human


Anatomical context of Adenoviruses, Human


Gene context of Adenoviruses, Human

  • Human adenoviruses have evolved strategies to regulate p53 function and stability to permit efficient viral replication [25].
  • A recombinant human adenovirus expressing a kinase-inactive mutant of JNK1 (APF mutant) was used to determine the biological effect of blocking JNK activity in Nb2 cells [26].
  • It has been known for some time that expression of the 243-residue (243R) human adenovirus type 5 (Ad5) early region 1A (E1A) protein causes an increase in the level of the cellular tumor suppressor p53 and induction of p53-dependent apoptosis [27].
  • In order to test this concept, a recombinant serotype Ad5 human adenovirus encoding a secreted form of VCAM-1 (Ad.CBsVCAM) was constructed [28].
  • The CR3 activation domain of the human adenovirus E1A protein stimulates transcription by forming protein-protein interactions with DNA sequence-specific binding factors and components of the TFIID complex [29].

Analytical, diagnostic and therapeutic context of Adenoviruses, Human


  1. A 14,700 MW protein from the E3 region of adenovirus inhibits cytolysis by tumor necrosis factor. Gooding, L.R., Elmore, L.W., Tollefson, A.E., Brady, H.A., Wold, W.S. Cell (1988) [Pubmed]
  2. Purification of an adenovirus-coded DNA polymerase that is required for initiation of DNA replication. Stillman, B.W., Tamanoi, F., Mathews, M.B. Cell (1982) [Pubmed]
  3. Transfection of fetal rat intestinal epithelial cells by viral oncogenes: establishment and characterization of the E1A-immortalized SLC-11 cell line. Emami, S., Mir, L., Gespach, C., Rosselin, G. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  4. Evidence that the penton base of adenovirus is involved in potentiation of toxicity of Pseudomonas exotoxin conjugated to epidermal growth factor. Seth, P., Fitzgerald, D., Ginsberg, H., Willingham, M., Pastan, I. Mol. Cell. Biol. (1984) [Pubmed]
  5. Isolation and properties of adenovirus type 2 proteinase. Tihanyi, K., Bourbonnière, M., Houde, A., Rancourt, C., Weber, J.M. J. Biol. Chem. (1993) [Pubmed]
  6. Epidermal growth factor receptor is down-regulated by a 10,400 MW protein encoded by the E3 region of adenovirus. Carlin, C.R., Tollefson, A.E., Brady, H.A., Hoffman, B.L., Wold, W.S. Cell (1989) [Pubmed]
  7. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Bischoff, J.R., Kirn, D.H., Williams, A., Heise, C., Horn, S., Muna, M., Ng, L., Nye, J.A., Sampson-Johannes, A., Fattaey, A., McCormick, F. Science (1996) [Pubmed]
  8. Positive and negative regulation of the gene for transcription factor IIIA in Xenopus laevis oocytes. Scotto, K.W., Kaulen, H., Roeder, R.G. Genes Dev. (1989) [Pubmed]
  9. The structure of the human adenovirus 2 penton. Zubieta, C., Schoehn, G., Chroboczek, J., Cusack, S. Mol. Cell (2005) [Pubmed]
  10. Possible role for a human adenovirus in the pathogenesis of celiac disease. Kagnoff, M.F., Austin, R.K., Hubert, J.J., Bernardin, J.E., Kasarda, D.D. J. Exp. Med. (1984) [Pubmed]
  11. Adenovirus chromatin structure at different stages of infection. Daniell, E., Groff, D.E., Fedor, M.J. Mol. Cell. Biol. (1981) [Pubmed]
  12. Increase in type I cyclic adenosine 3':5'-monophosphate-dependent protein kinase activity and specific accumulation of type I regulatory subunits in adenovirus type 12-transformed cells. Ledinko, N., Chan, I.J. Cancer Res. (1984) [Pubmed]
  13. Receptor-mediated delivery of hepatitis B virus DNA and antisense oligodeoxynucleotides to avian liver cells. Madon, J., Blum, H.E. Hepatology (1996) [Pubmed]
  14. Resistance of human cells to the adenovirus E3 effect on class I MHC antigen expression. Implications for antiviral immunity. Routes, J.M., Cook, J.L. J. Immunol. (1990) [Pubmed]
  15. Recognition of the adenovirus type 2 origin of DNA replication by the virally encoded DNA polymerase and preterminal proteins. Temperley, S.M., Hay, R.T. EMBO J. (1992) [Pubmed]
  16. Integrin alpha v beta 5 selectively promotes adenovirus mediated cell membrane permeabilization. Wickham, T.J., Filardo, E.J., Cheresh, D.A., Nemerow, G.R. J. Cell Biol. (1994) [Pubmed]
  17. Introduction, stable integration, and controlled expression of a chimeric adenovirus gene whose product is toxic to the recipient human cell. Klessig, D.F., Brough, D.E., Cleghon, V. Mol. Cell. Biol. (1984) [Pubmed]
  18. Point mutations in the regulatory region of the human adenoviral VAI gene. Rohan, R.M., Ketner, G. J. Biol. Chem. (1983) [Pubmed]
  19. Cellular context of coregulator and adaptor proteins regulates human adenovirus 5 early region 1A-dependent gene activation by the thyroid hormone receptor. Meng, X., Yang, Y.F., Cao, X., Govindan, M.V., Shuen, M., Hollenberg, A.N., Mymryk, J.S., Walfish, P.G. Mol. Endocrinol. (2003) [Pubmed]
  20. Patch homologies and the integration of adenovirus DNA in mammalian cells. Gahlmann, R., Leisten, R., Vardimon, L., Doerfler, W. EMBO J. (1982) [Pubmed]
  21. Adenovirus E1A renders infected cells sensitive to cytolysis by tumor necrosis factor. Duerksen-Hughes, P., Wold, W.S., Gooding, L.R. J. Immunol. (1989) [Pubmed]
  22. Rejection of intraocular tumors by CD4(+) T cells without induction of phthisis. Schurmans, L.R., Diehl, L., den Boer, A.T., Sutmuller, R.P., Boonman, Z.F., Medema, J.P., van der Voort, E.I., Laman, J., Melief, C.J., Jager, M.J., Toes, R.E. J. Immunol. (2001) [Pubmed]
  23. Characterization of adenovirus type 2 transcriptional complexes isolated from infected HeLa cell nuclei. Wilhelm, J., Brison, O., Kedinger, C., Chambon, P. J. Virol. (1976) [Pubmed]
  24. Adenovirus DNA is associated with the nuclear matrix of infected cells. Younghusband, H.B., Maundrell, K. J. Virol. (1982) [Pubmed]
  25. Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex. Querido, E., Blanchette, P., Yan, Q., Kamura, T., Morrison, M., Boivin, D., Kaelin, W.G., Conaway, R.C., Conaway, J.W., Branton, P.E. Genes Dev. (2001) [Pubmed]
  26. Prolactin stimulates activation of c-jun N-terminal kinase (JNK). Schwertfeger, K.L., Hunter, S., Heasley, L.E., Levresse, V., Leon, R.P., DeGregori, J., Anderson, S.M. Mol. Endocrinol. (2000) [Pubmed]
  27. Accumulation of p53 induced by the adenovirus E1A protein requires regions involved in the stimulation of DNA synthesis. Querido, E., Teodoro, J.G., Branton, P.E. J. Virol. (1997) [Pubmed]
  28. A recombinant adenoviral vector expressing a soluble form of VCAM-1 inhibits VCAM-1/VLA-4 adhesion in transduced synoviocytes. Chen, S.J., Wilson, J.M., Vallance, D.K., Hartman, J.W., Davidson, B.L., Roessler, B.J. Gene Ther. (1995) [Pubmed]
  29. The transactivation domain of adenovirus E1A interacts with the C terminus of human TAF(II)135. Mazzarelli, J.M., Mengus, G., Davidson, I., Ricciardi, R.P. J. Virol. (1997) [Pubmed]
  30. Structure of adenovirus complexed with its internalization receptor, alphavbeta5 integrin. Chiu, C.Y., Mathias, P., Nemerow, G.R., Stewart, P.L. J. Virol. (1999) [Pubmed]
  31. Type-specific epitope locations revealed by X-ray crystallographic study of adenovirus type 5 hexon. Rux, J.J., Burnett, R.M. Mol. Ther. (2000) [Pubmed]
  32. Preparation and crystallization of a complex between human adenovirus serotype 2 proteinase and its 11-amino-acid cofactor pVIc. McGrath, W.J., Ding, J., Sweet, R.M., Mangel, W.F. J. Struct. Biol. (1996) [Pubmed]
  33. Rapid subgenus identification of human adenovirus isolates by a general PCR. Kidd, A.H., Jonsson, M., Garwicz, D., Kajon, A.E., Wermenbol, A.G., Verweij, M.W., De Jong, J.C. J. Clin. Microbiol. (1996) [Pubmed]
  34. Polypeptide phosphorylation in adenovirus-infected cells. Russell, W.C., Blair, G.E. J. Gen. Virol. (1977) [Pubmed]
WikiGenes - Universities