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MeSH Review:

Osteoarthropathy, Primary Hypertrophic

Bianchi, L. et al., Kirkpatrick, J.N. et al., Venencie, P.Y. et al., Tay, Y.K. et al., Oikarinen, A. et al., et al.

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Disease relevance of Osteoarthropathy, Primary Hypertrophic

The elevated serum bone Gla-protein (osteocalcin) favors the hypothesis that primary hypertrophic osteoarthropathy represents an imbalance between increased osteoblastic bone formation and normal bone resorption [1].
The histological and ultrastructural appearances of the eyelids show sebaceous gland hyperplasia and excessive deposition of mucin in the dermis and would suggest that pachydermoperiostosis may be an example of a cutaneous mucinosis [2].
Pachydermoperiostosis with myelofibrosis and anemia: report of a case of anemia of multifactorial causes and its improvement with steroid pulse and iron therapy [3].

High impact information on Osteoarthropathy, Primary Hypertrophic

Pachydermoperiostosis: technetium-99m-methylene diphosphonate scintigraphic pattern [4].
Synthesis and degradation of connective tissue macromolecules in pachydermoperiostosis (PDP): evidence for altered processing of plasminogen activator inhibitor-1 (PAI-1) [5].
We studied a patient with the incomplete form of pachydermoperiostosis, assessing epidermal growth factor receptor (EGF-R) and sex hormone steroid receptors (SR) in the affected skin, and also evaluating the urinary excretion of EGF [6].
Pachydermoperiostosis: study of epidermal growth factor and steroid receptors [6].
Classically, pachydermoperiostosis is characterised by a triad of finger clubbing, periosteal new bone formation, skin and soft tissue changes, giving an acromaegaloid look [7].

Chemical compound and disease context of Osteoarthropathy, Primary Hypertrophic

Pachydermoperiostosis: trial with isotretinoin [8].

References

Pachydermoperiostosis with gastric hypertrophy, anemia, and increased serum bone Gla-protein levels. Venencie, P.Y., Boffa, G.A., Delmas, P.D., Verola, O., Benkaïdali, I., Frija, J., Pillet, B., Puissant, A. Archives of dermatology. (1988) [Pubmed]
Ptosis caused by pachydermoperiostosis. Kirkpatrick, J.N., McKee, P.H., Spalton, D.J. The British journal of ophthalmology. (1991) [Pubmed]
Pachydermoperiostosis with myelofibrosis and anemia: report of a case of anemia of multifactorial causes and its improvement with steroid pulse and iron therapy. Tanaka, H., Maehama, S., Imanaka, F., Sakai, A., Abe, K., Hamada, M., Yamashita, J., Kimura, A., Imamura, N., Fujimura, K. Jpn. J. Med. (1991) [Pubmed]
Pachydermoperiostosis: technetium-99m-methylene diphosphonate scintigraphic pattern. Bomanji, J., Nagaraj, N., Jewkes, R., Fields, M., Maini, R.N. J. Nucl. Med. (1991) [Pubmed]
Synthesis and degradation of connective tissue macromolecules in pachydermoperiostosis (PDP): evidence for altered processing of plasminogen activator inhibitor-1 (PAI-1). Oikarinen, A., Kylmäniemi, M., Palatsi, R., Keski-Oja, J. Exp. Dermatol. (1995) [Pubmed]
Pachydermoperiostosis: study of epidermal growth factor and steroid receptors. Bianchi, L., Lubrano, C., Carrozzo, A.M., Iraci, S., Tomassoli, M., Spera, G., Nini, G. Br. J. Dermatol. (1995) [Pubmed]
Pachydermoperiostosis (idiopathic hypertrophic osteoarthropathy)--a case report and review. Tay, Y.K., Tham, S.N., Tey, B.H., Koay, L.H. Ann. Acad. Med. Singap. (1993) [Pubmed]
Pachydermoperiostosis: trial with isotretinoin. Park, Y.K., Kim, H.J., Chung, K.Y. Yonsei Med. J. (1988) [Pubmed]

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