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MeSH Review:

Maximal Midexpiratory Flow Rate

Kreisman, H. et al., Doshan, H.D. et al., D'Angelo, E. et al., Pande, J.N., Guleria, R. et al., et al.

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Disease relevance of Maximal Midexpiratory Flow Rate

Fifty patients with fibrosing alveolitis studied on 104 occasions exhibited significant direct correlations between vital capacity (VC), maximum mid-expiratory flow rate (MMFR), and transfer factor for carbon monoxide (TLCO) [1].

High impact information on Maximal Midexpiratory Flow Rate

Main findings were: peak expiratory flow (PEF), FEV1, and maximal midexpiratory flow rate (MMF) were significantly larger with maneuver 1 than 2; after salbutamol administration and during helium-oxygen breathing, all indices increased significantly with both maneuvers but the relative differences between maneuvers 1 and 2 were unchanged [2].
Pulmonary function (forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and maximal mid expiratory flow rate (MMFR) and weight were measured in both surveys [3].
FEV1 and MMFR were significantly increased (p less than 0.05) 30 and 60 minutes after ipratropium inhalation and this increase was significantly greater when the patient had also been taking theophylline compared with placebo capsules (p less than 0.05) [4].
There was a significant increase in FEV1 and MMFR 60 minutes after theophylline was administered (p less than 0.05) when measured after one and two weeks of therapy [4].
Five of 7 patients compared with 4 of 31 controls tested at 3 months had an abnormal FER or maximum mid-expiratory flow rate (MMFR), but not VC, prior to the onset of symptoms (P = 0.015) [5].

Biological context of Maximal Midexpiratory Flow Rate

Changes in one-second forced expiratory volume (FEV1) and maximal midexpiratory flow rate (FEF25-75) prior to albuterol or isoproterenol were positive after placebo and both doses of celiprolol [6].

Associations of Maximal Midexpiratory Flow Rate with chemical compounds

No significant changes were seen either after propranolol or after antithyroid drugs in the FRC, RV, TLC, MMFR, DLCO, or blood gases [7].
After oxprenolol significant difference was seen only with MMFR in the moderate smokers [8].
Thus, a combination fenoterol and ipratropium bromide produced a more prolonged bronchodilatation, and ipratropium bromide perhaps acts both in the major (indicated by rise in FEV1) and small airways (measured by MMFR) [9].

Gene context of Maximal Midexpiratory Flow Rate

Maximal midexpiratory flow rate (FEF25-75%) decreased by 3.6% (95% CI 0.9 to 6.3) per each 1000-m altitude increment [10].

References

Interrelationship between lung volume, expiratory flow, and lung transfer factor in fibrosing alveolitis. Pande, J.N. Thorax (1981) [Pubmed]
Effects of bronchomotor tone and gas density on time dependence of forced expiratory vital capacity maneuver. D'Angelo, E., Milic-Emili, J., Marazzini, L. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
Body weight and weight gain related to pulmonary function decline in adults: a six year follow up study. Chen, Y., Horne, S.L., Dosman, J.A. Thorax (1993) [Pubmed]
Synergism between ipratropium and theophylline in asthma. Kreisman, H., Frank, H., Wolkove, N., Gent, M. Thorax (1981) [Pubmed]
Chronic airflow obstruction in long-term survivors of allogeneic bone marrow transplantation. Curtis, D.J., Smale, A., Thien, F., Schwarer, A.P., Szer, J. Bone Marrow Transplant. (1995) [Pubmed]
Celiprolol, atenolol and propranolol: a comparison of pulmonary effects in asthmatic patients. Doshan, H.D., Rosenthal, R.R., Brown, R., Slutsky, A., Applin, W.J., Caruso, F.S. J. Cardiovasc. Pharmacol. (1986) [Pubmed]
Lung function and respiratory muscle strength after propranolol in thyrotoxicosis. Wang, Y.T., Poh, S.C. Australian and New Zealand journal of medicine. (1986) [Pubmed]
Effect of beta-blockers on ventilatory function in smokers and non smokers. Shah, P.K., Lakhotia, M., Gupta, A., Mehta, S., Borana, G., Gupta, S.K. The Journal of the Association of Physicians of India. (1993) [Pubmed]
Comparison of bronchodilatation produced by an anticholinergic (ipratropium bromide), a beta-2 adrenergic (fenoterol) and their combination in patients with chronic obstructive airway disease. An open trial. Guleria, R., Behera, D., Jindal, S.K. The Journal of the Association of Physicians of India. (1991) [Pubmed]
Pulmonary ventilatory function decreases in proportion to increasing altitude. Hashimoto, F., McWilliams, B., Qualls, C. Wilderness & environmental medicine. (1997) [Pubmed]

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