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MeSH Review

Sickness Impact Profile

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Disease relevance of Sickness Impact Profile


Psychiatry related information on Sickness Impact Profile


High impact information on Sickness Impact Profile

  • Compared with the FV group, the PT group experienced no significant improvements in overall Physical Disability Index, Sickness Impact Profile, or activities of daily living scores [11].
  • METHODS:The Sickness Impact Profile (SIP), Short Form 36 (SF-36), Rating Form of Inflammatory Bowel Disease (IBD) Patient Concerns (RFIPC), and the time trade-off (TTO) were used to measure HRQL of pull-through patients [12].
  • METHODS: The authors prospectively studied 96 patients with ALS using several instruments, including the McGill Quality of Life (MQOL) instrument, the Idler Index of Religiosity, the Sickness Impact Profile (SIP)/ALS-19, and several measures of strength and physical function [13].
  • We found the largest differences in frequencies of symptoms of disequilibrium, difficulties with speech or swallowing, the Timed Walking Test, and the body care and movement subscale of the Sickness Impact Profile. Except for disequilibrium (p = 0.04), these differences did not reach statistical significance [14].
  • Relationship of the Tufts Quantitative Neuromuscular Exam (TQNE) and the Sickness Impact Profile (SIP) in measuring progression of ALS. SSNJV/CNTF ALS Study Group [15].

Biological context of Sickness Impact Profile


Anatomical context of Sickness Impact Profile

  • METHOD: Subjects (n = 30) were measured at home and correlations were calculated between the Upper Limb Activity Monitor and 4 questionnaires; Sickness Impact Profile, RAND-36 Health Survey, Disabilities of Arm Shoulder Hand Questionnaire and Radboud Skills Questionnaire [21].

Associations of Sickness Impact Profile with chemical compounds

  • Reduced serum tryptophan was significantly associated with Rotterdam Symptom Checklist physical symptom (r=-0.51, P=0.01) and Sickness Impact Profile (r=-0.42, P=0.04) scores, and correlated with increased serum neopterin (r=-0.36, P=0.003), IL-2 sRalpha (r=-0.51, P=0.01) and sTNF RI (r=-0.45, P=0.02) levels [22].
  • MEASUREMENTS: Demographics, time to first fall and all subsequent falls, functional measures, Sickness Impact Profile, Centers for Epidemiologic Studies-Depression Scale, Activities-specific Balance Confidence Scale, Falls Efficacy Scales, and adherence to interventions [23].
  • Outcomes included two disease-specific (the Oxygen Cost Diagram and the Chronic Respiratory Questionnaire [CRQ]) measures, a generic health profile (the Sickness Impact Profile [SIP]), and two utility measures (the Standard Gamble and the Quality of Well-Being index [QWB]) [24].
  • Sickness Impact Profile scores were no different between placebo and gabapentin [25].
  • Quality of life, assessed by the Sickness Impact Profile questionnaire, was significantly improved in patients receiving OPC-8212 (p less than 0.01) [26].

Gene context of Sickness Impact Profile


Analytical, diagnostic and therapeutic context of Sickness Impact Profile


  1. Employment after liver transplantation. Adams, P.C., Ghent, C.N., Grant, D.R., Wall, W.J. Hepatology (1995) [Pubmed]
  2. Outcome measurement in kidney disease. Kaplan, R.M., Mehta, R. Blood Purif. (1994) [Pubmed]
  3. Assessing health-related quality of life in chronic hepatitis C using the Sickness Impact Profile. Davis, G.L., Balart, L.A., Schiff, E.R., Lindsay, K., Bodenheimer, H.C., Perrillo, R.P., Carey, W., Jacobson, I.M., Payne, J., Dienstag, J.L. Clinical therapeutics. (1994) [Pubmed]
  4. Development and evaluation of modifications to the Sickness Impact Profile for head injury. Temkin, N., McLean, A., Dikmen, S., Gale, J., Bergner, M., Almes, M.J. Journal of clinical epidemiology. (1988) [Pubmed]
  5. Comparison of the Musculoskeletal Function Assessment questionnaire with the Short Form-36, the Western Ontario and McMaster Universities Osteoarthritis Index, and the Sickness Impact Profile health-status measures. Martin, D.P., Engelberg, R., Agel, J., Swiontkowski, M.F. The Journal of bone and joint surgery. American volume. (1997) [Pubmed]
  6. Team versus non-team outpatient care in rheumatoid arthritis. A comprehensive outcome evaluation including an overall health measure. Ahlmen, M., Sullivan, M., Bjelle, A. Arthritis Rheum. (1988) [Pubmed]
  7. Quality of life before and after orthotopic hepatic transplantation. Tarter, R.E., Switala, J., Arria, A., Plail, J., Van Thiel, D. Arch. Intern. Med. (1991) [Pubmed]
  8. Sexual difficulties of chronic pain patients. Ambler, N., Williams, A.C., Hill, P., Gunary, R., Cratchley, G. The Clinical journal of pain. (2001) [Pubmed]
  9. Studies of the Modified Somatic Perceptions Questionnaire (MSPQ) in patients with back pain. Psychometric and predictive properties. Deyo, R.A., Walsh, N.E., Schoenfeld, L.S., Ramamurthy, S. Spine. (1989) [Pubmed]
  10. OPC-8212 in the treatment of congestive heart failure: results of a pilot study. Kubo, S.H., Rector, T.S., Strobeck, J.E., Cohn, J.N. Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy. (1988) [Pubmed]
  11. A randomized trial of physical rehabilitation for very frail nursing home residents. Mulrow, C.D., Gerety, M.B., Kanten, D., Cornell, J.E., DeNino, L.A., Chiodo, L., Aguilar, C., O'Neil, M.B., Rosenberg, J., Solis, R.M. JAMA (1994) [Pubmed]
  12. Health-related quality of life after ileoanal pull-through evaluation and assessment of new health status measures. Provenzale, D., Shearin, M., Phillips-Bute, B.G., Drossman, D.A., Li, Z., Tillinger, W., Schmitt, C.M., Bollinger, R.R., Koruda, M.J. Gastroenterology (1997) [Pubmed]
  13. Quality of life in ALS depends on factors other than strength and physical function. Simmons, Z., Bremer, B.A., Robbins, R.A., Walsh, S.M., Fischer, S. Neurology (2000) [Pubmed]
  14. Disequilibrium in patients with atherosclerosis: relevance of pontine ischemic rarefaction. Amsterdam Vascular Medicine Group. Kwa, V.I., Zaal, L.H., Verbeeten, B., Stam, J. Neurology (1998) [Pubmed]
  15. Relationship of the Tufts Quantitative Neuromuscular Exam (TQNE) and the Sickness Impact Profile (SIP) in measuring progression of ALS. SSNJV/CNTF ALS Study Group. McGuire, D., Garrison, L., Armon, C., Barohn, R., Bryan, W., Miller, R., Parry, G., Petajan, J., Ross, M. Neurology (1996) [Pubmed]
  16. Assessment of subjective health and health-related quality of life in persons with acquired or degenerative brain injury. von Steinbuechel, N., Richter, S., Morawetz, C., Riemsma, R. Curr. Opin. Neurol. (2005) [Pubmed]
  17. National study of cataract surgery outcomes. Variation in 4-month postoperative outcomes as reflected in multiple outcome measures. Steinberg, E.P., Tielsch, J.M., Schein, O.D., Javitt, J.C., Sharkey, P., Cassard, S.D., Legro, M.W., Diener-West, M., Bass, E.B., Damiano, A.M. Ophthalmology (1994) [Pubmed]
  18. Reliability and validity of a Swedish version of the St George's Respiratory Questionnaire. Engström, C.P., Persson, L.O., Larsson, S., Sullivan, M. Eur. Respir. J. (1998) [Pubmed]
  19. An evaluation of a brief health status measure in elderly veterans. Weinberger, M., Samsa, G.P., Hanlon, J.T., Schmader, K., Doyle, M.E., Cowper, P.A., Uttech, K.M., Cohen, H.J., Feussner, J.R. Journal of the American Geriatrics Society. (1991) [Pubmed]
  20. A brief quality-of-life measure for ALS clinical trials based on a subset of items from the sickness impact profile. The Syntex-Synergen ALS/CNTF Study Group. McGuire, D., Garrison, L., Armon, C., Barohn, R.J., Bryan, W.W., Miller, R., Parry, G.J., Petajan, J.H., Ross, M.A. J. Neurol. Sci. (1997) [Pubmed]
  21. Correlation between a novel upper limb activity monitor and four other instruments to determine functioning in upper limb complex regional pain syndrome type I. Schasfoort, F.C., Bussmann, J.B., Stam, H.J. Journal of rehabilitation medicine : official journal of the UEMS European Board of Physical and Rehabilitation Medicine. (2005) [Pubmed]
  22. Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer. Huang, A., Fuchs, D., Widner, B., Glover, C., Henderson, D.C., Allen-Mersh, T.G. Br. J. Cancer (2002) [Pubmed]
  23. Intense tai chi exercise training and fall occurrences in older, transitionally frail adults: a randomized, controlled trial. Wolf, S.L., Sattin, R.W., Kutner, M., O'Grady, M., Greenspan, A.I., Gregor, R.J. Journal of the American Geriatrics Society. (2003) [Pubmed]
  24. Generic and specific measurement of health-related quality of life in a clinical trial of respiratory rehabilitation. Guyatt, G.H., King, D.R., Feeny, D.H., Stubbing, D., Goldstein, R.S. Journal of clinical epidemiology. (1999) [Pubmed]
  25. Double-blind controlled trial of gabapentin in essential tremor. Pahwa, R., Lyons, K., Hubble, J.P., Busenbark, K., Rienerth, J.D., Pahwa, A., Koller, W.C. Mov. Disord. (1998) [Pubmed]
  26. Usefulness of OPC-8212, a quinolinone derivative, for chronic congestive heart failure in patients with ischemic heart disease or idiopathic dilated cardiomyopathy. Feldman, A.M., Baughman, K.L., Lee, W.K., Gottlieb, S.H., Weiss, J.L., Becker, L.C., Strobeck, J.E. Am. J. Cardiol. (1991) [Pubmed]
  27. High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study. Graf, M., Ecker, D., Horowski, R., Kramer, B., Riederer, P., Gerlach, M., Hager, C., Ludolph, A.C., Becker, G., Osterhage, J., Jost, W.H., Schrank, B., Stein, C., Kostopulos, P., Lubik, S., Wekwerth, K., Dengler, R., Troeger, M., Wuerz, A., Hoge, A., Schrader, C., Schimke, N., Krampfl, K., Petri, S., Zierz, S., Eger, K., Neudecker, S., Traufeller, K., Sievert, M., Neundörfer, B., Hecht, M. Journal of neural transmission (Vienna, Austria : 1996) (2005) [Pubmed]
  28. Measuring self-efficacy in people with multiple sclerosis: a validation study. Schwartz, C.E., Coulthard-Morris, L., Zeng, Q., Retzlaff, P. Archives of physical medicine and rehabilitation. (1996) [Pubmed]
  29. Toward clinical applications of health status measures: sensitivity of scales to clinically important changes. Deyo, R.A., Inui, T.S. Health services research. (1984) [Pubmed]
  30. Effects of haemoglobin normalization on quality of life and cardiovascular parameters in end-stage renal failure. McMahon, L.P., Mason, K., Skinner, S.L., Burge, C.M., Grigg, L.E., Becker, G.J. Nephrol. Dial. Transplant. (2000) [Pubmed]
  31. Impact of Huntington's disease on quality of life. Helder, D.I., Kaptein, A.A., van Kempen, G.M., van Houwelingen, J.C., Roos, R.A. Mov. Disord. (2001) [Pubmed]
  32. Pulmonary function and health-related quality of life in survivors of acute respiratory distress syndrome. Orme, J., Romney, J.S., Hopkins, R.O., Pope, D., Chan, K.J., Thomsen, G., Crapo, R.O., Weaver, L.K. Am. J. Respir. Crit. Care Med. (2003) [Pubmed]
  33. Validity of the Sickness Impact Profile Roland scale as a measure of dysfunction in chronic pain patients. Jensen, M.P., Strom, S.E., Turner, J.A., Romano, J.M. Pain (1992) [Pubmed]
  34. Continuous passive motion for osteoarthritis of the hip: a pilot study. Simkin, P.A., de Lateur, B.J., Alquist, A.D., Questad, K.A., Beardsley, R.M., Esselman, P.C. J. Rheumatol. (1999) [Pubmed]
  35. Relationship between physical performance and self-perceived physical function. Cress, M.E., Schechtman, K.B., Mulrow, C.D., Fiatarone, M.A., Gerety, M.B., Buchner, D.M. Journal of the American Geriatrics Society. (1995) [Pubmed]
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