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MeSH Review:

Trial of Labor

Penso, C., Kolderup, L. et al., Magann, E.F. et al., Flamm, B.L. et al., Plaut, M.M. et al., et al.

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Disease relevance of Trial of Labor

OBJECTIVE: Our purpose is to report our experience with uterine rupture in patients undergoing a trial of labor after previous cesarean delivery in which labor was induced with misoprostol [1].

High impact information on Trial of Labor

A trial of labor for remifentanil [2].
STUDY DESIGN: In a randomized, controlled trial of labor induction, patients were randomly assigned to receive either 50 microgram of intravaginal misoprostol every 4 hours or 0.5 mg of intracervical prostaglandin E2 every 6 hours [3].
A trial of labor was successful in 22% of patients with an initial modified Bishop score < or = 2 versus 45% with an initial Bishop > 2 (odds ratio 0.5, 95% confidence interval 0.2 to 1.3, p = 0.16) [4].
A trial of labor should be attempted in the face of a positive CST whenever obstetric factors are favorable and careful intrapartum monitoring can be performed [5].
To evaluate the maternal and fetal outcomes of a large cohort of women treated with prostaglandin E2 (PGE2) gel for cervical ripening prior to trial of labor after previous cesarean delivery [6].

Chemical compound and disease context of Trial of Labor

CONCLUSION: The risk of uterine rupture was significantly increased in patients undergoing a trial of labor after previous cesarean section when a PGE2 vaginal insert was used [7].

Biological context of Trial of Labor

Changing trends in the management of labor may also contribute to an increase in successful trial of labor with the use of oxytocin for the induction or augmentation of labor, the administration of epidural anesthesia for pain relief, and the instillation of prostaglandin E2 gel for cervical ripening [8].

Associations of Trial of Labor with chemical compounds

A comparative trial of labor induction with misoprostol versus oxytocin [9].

References

Uterine rupture associated with the use of misoprostol in the gravid patient with a previous cesarean section. Plaut, M.M., Schwartz, M.L., Lubarsky, S.L. Am. J. Obstet. Gynecol. (1999) [Pubmed]
A trial of labor for remifentanil. Saunders, T.A., Glass, P.S. Anesth. Analg. (2002) [Pubmed]
Misoprostol is more efficacious for labor induction than prostaglandin E2, but is it associated with more risk? Kolderup, L., McLean, L., Grullon, K., Safford, K., Kilpatrick, S.J. Am. J. Obstet. Gynecol. (1999) [Pubmed]
Factors relevant to mode of preterm delivery with syndrome of HELLP (hemolysis, elevated liver enzymes, and low platelets). Magann, E.F., Roberts, W.E., Perry, K.G., Chauhan, S.P., Blake, P.G., Martin, J.N. Am. J. Obstet. Gynecol. (1994) [Pubmed]
Antepartum fetal heart rate testing. II. Intrapartum fetal heart rate observation and newborn outcome following a positive contraction stress test. Gauthier, R.J., Evertson, L.R., Paul, R.H. Am. J. Obstet. Gynecol. (1979) [Pubmed]
Prostaglandin E2 for cervical ripening: a multicenter study of patients with prior cesarean delivery. Flamm, B.L., Anton, D., Goings, J.R., Newman, J. American journal of perinatology. (1997) [Pubmed]
Uterine rupture with the use of PGE2 vaginal inserts for labor induction in women with previous cesarean sections. Taylor, D.R., Doughty, A.S., Kaufman, H., Yang, L., Iannucci, T.A. The Journal of reproductive medicine. (2002) [Pubmed]
Vaginal birth after cesarean section: an update on physician trends and patient perceptions. Penso, C. Current opinion in obstetrics & gynecology. (1994) [Pubmed]
A comparative trial of labor induction with misoprostol versus oxytocin. Escudero, F., Contreras, H. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. (1997) [Pubmed]

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