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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Periostitis

  • Evaluation of the pelvic radiographs of both symptomatic and asymptomatic HLA B27 positive subjects and symptomatic HLA B27 negative controls demonstrated that osteitis pubis and fluffy periostitis are equally distributed among the three groups, only the frequency of sacroiliitis being statistically greater in the B27 positive symptomatic subjects [1].
  • The periostitis resulted from long-term therapy with PGE1, which was administered to maintain patency of the ductus in a neonate with ductal-dependent cyanotic congenital heart disease [2].
  • Awareness of this entity is essential not only for the treatment team caring for these infants but also for consultant pediatric orthopaedists to avoid excessive investigation for infection, metabolic disease, or vitamin deficiencies that resemble prostaglandin-induced periostitis [3].
  • Cortical hyperostosis of the long bones is one of the complications during and after PGE1 therapy and should be considered in the differential diagnosis of periostitis in the infant [4].
  • Case report 413: Florid reactive periostitis of the proximal phalanx of the fourth finger (parosteal fasciitis, pseudosarcomatous fibromatosis, fasciitis ossificans) [5].

High impact information on Periostitis

  • With the exception of extensive proliferative periostitis, ASP simulated classic rheumatoid arthritis [6].
  • Proposed diagnostic criteria for HOA, including digital clubbing and radiographic periostitis, appear 86% sensitive [7].
  • Psoriatic onycho-pachydermo periostitis: treatment with methotrexate [8].
  • The classic triad of clubbing, periostitis, and arthritis was present along with typical radiographic and bone scan findings [9].
  • All patients had normal bones before IL-11 was given, changes occurred in both non-malignant and malignant diseases, and periostitis disappeared after use of the drug was discontinued [10].

Chemical compound and disease context of Periostitis


Gene context of Periostitis


Analytical, diagnostic and therapeutic context of Periostitis

  • Bone scintigraphy has emerged as the most sensitive test for HOA; in fact, a bone scan may show evidence of periostitis in patients with no other signs, symptoms, or radiographic abnormalities of the disorder [18].


  1. The close correlation between symptoms and disease expression in HLA B27 positive individuals. Calin, A., Fries, J.F., Schurman, D., Payne, R. J. Rheumatol. (1977) [Pubmed]
  2. Case report 701: Prostaglandin E1 (PGE1) periostitis. Rowley, R.F., Lawson, J.P. Skeletal radiology. (1991) [Pubmed]
  3. Prostaglandin-induced neonatal periostitis. Letts, M., Pang, E., Simons, J. Journal of pediatric orthopedics. (1994) [Pubmed]
  4. Cortical hyperostosis: a complication of prostaglandin E1 treatment in congenital heart disease. Smet, M.H., Marchal, G., Lambert, L., Devlieger, H., Gewillig, M. Journal belge de radiologie. (1989) [Pubmed]
  5. Case report 413: Florid reactive periostitis of the proximal phalanx of the fourth finger (parosteal fasciitis, pseudosarcomatous fibromatosis, fasciitis ossificans). Holmes, W.S., Pope, T.L., de Lange, E., Fechner, R.E., McDowel, C.L., Keats, T.E. Skeletal radiology. (1987) [Pubmed]
  6. Arthritis associated with HIV infection: radiographic manifestations. Rosenberg, Z.S., Norman, A., Solomon, G. Radiology. (1989) [Pubmed]
  7. Primary hypertrophic osteoarthropathy. Martínez-Lavín, M., Pineda, C., Valdez, T., Cajigas, J.C., Weisman, M., Gerber, N., Steigler, D. Semin. Arthritis Rheum. (1988) [Pubmed]
  8. Psoriatic onycho-pachydermo periostitis: treatment with methotrexate. Bauzá, A., Redondo, P., Aquerreta, D. Br. J. Dermatol. (2000) [Pubmed]
  9. Hypertrophic osteoarthropathy associated with a rejected liver transplant. Wolfe, S.M., Aelion, J.A., Gupta, R.C. J. Rheumatol. (1987) [Pubmed]
  10. Periostitis secondary to interleukin-11 (Oprelvekin, Neumega). Treatment for thrombocytopenia in pediatric patients. Milman, E., Berdon, W.E., Garvin, J.H., Cairo, M.S., Bessmertny, O., Ruzal-Shapiro, C. Pediatric radiology. (2003) [Pubmed]
  11. Scintigraphic diagnosis of prostaglandin induced periostitis. Wulfeck, D.W., Williams, T.E., Eberly, S. Clinical nuclear medicine. (1995) [Pubmed]
  12. Pediatric update #15. Florid reactive periostitis of the digits. Landsman, J.C., Shall, J.F., Seitz, W.H., Berner, J.J. Orthopaedic review. (1990) [Pubmed]
  13. Periostitis associated with phenol matricectomies. Gilles, G.A., Dennis, K.J., Harkless, L.B. Journal of the American Podiatric Medical Association. (1986) [Pubmed]
  14. Periostitis due to low-dose fluoride intoxication demonstrated by bone scanning. Weingrad, T.R., Eymontt, M.J., Martin, J.H., Steltz, M.D. Clinical nuclear medicine. (1991) [Pubmed]
  15. The seronegative spondyloarthropathies. Kettering, J.M., Towers, J.D., Rubin, D.A. Seminars in roentgenology. (1996) [Pubmed]
  16. Laminar periostitis and multiple osteonecrosis in systemic lupus erythematosus. Burson, J.S., Graña, J., Varela, J., Atanes, A., Galdo, F. Clin. Rheumatol. (1990) [Pubmed]
  17. Allergic rhinitis as a risk factor for orbital complication of acute rhinosinusitis in children. Holzmann, D., Willi, U., Nadal, D. American journal of rhinology. (2001) [Pubmed]
  18. Clubbing and hypertrophic osteoarthropathy. Hansen-Flaschen, J., Nordberg, J. Clin. Chest Med. (1987) [Pubmed]
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