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MeSH Review

Sertoli-Leydig Cell Tumor

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Disease relevance of Sertoli-Leydig Cell Tumor


High impact information on Sertoli-Leydig Cell Tumor


Chemical compound and disease context of Sertoli-Leydig Cell Tumor


Biological context of Sertoli-Leydig Cell Tumor

  • The clinical course, histology, and steroid secretion of a 59-year-old postmenopausal woman with a 4-yr history of virilizing well-differentiated Sertoli-Leydig cell tumor of the right ovary are reported [14].
  • A case of virilizing ovarian Sertoli-Leydig cell tumor overexpressing the BCL2 gene and including a novel clonal chromosomal rearrangement of chromosome 18, der(5)t(5;18)(p13;q12),+6,+12, der(18)r(5;18)(p15.3p13;p11.3q12) is described [15].

Anatomical context of Sertoli-Leydig Cell Tumor


Gene context of Sertoli-Leydig Cell Tumor


Analytical, diagnostic and therapeutic context of Sertoli-Leydig Cell Tumor


  1. Evaluation of receptors for somatostatin in various tumors using different analogs. Srkalovic, G., Cai, R.Z., Schally, A.V. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
  2. Calretinin, a more sensitive but less specific marker than alpha-inhibin for ovarian sex cord-stromal neoplasms: an immunohistochemical study of 215 cases. Movahedi-Lankarani, S., Kurman, R.J. Am. J. Surg. Pathol. (2002) [Pubmed]
  3. Presence of 17 beta-hydroxysteroid dehydrogenase type 3 messenger ribonucleic acid transcript in an ovarian Sertoli-Leydig cell tumor. Barbieri, R.L., Gao, X. Fertil. Steril. (1997) [Pubmed]
  4. Hirsutism caused by an androgen-producing ovarian tumor. A case of arrhenoblastoma. Lunde, O., Djoseland, O. J. Endocrinol. Invest. (1986) [Pubmed]
  5. Sertoli-Leydig cell tumor of the ovary producing alpha-fetoprotein. Chumas, J.C., Rosenwaks, Z., Mann, W.J., Finkel, G., Pastore, J. Int. J. Gynecol. Pathol. (1984) [Pubmed]
  6. Norethindrone inhibition of testosterone secretion by an ovarian Sertoli-Leydig cell tumor. Brumsted, J.R., Chapitis, J., Riddick, D., Gibson, M. J. Clin. Endocrinol. Metab. (1987) [Pubmed]
  7. Testosterone secretion by cultured arrhenoblastoma cells: suppression by a luteinizing hormone-releasing hormone agonist. Lamberts, S.W., Timmers, J.M., Oosterom, R., Verleun, T., de Jong, F.H. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
  8. Ovarian Sertoli-Leydig cell tumor: a SRY gene-independent pathway of pseudomale gonadal differentiation. Hittmair, A., Zelger, B.G., Obrist, P., Dirnhofer, S. Hum. Pathol. (1997) [Pubmed]
  9. Immunohistochemistry of unclassified sex cord-stromal tumors of the testis with a predominance of spindle cells. Renshaw, A.A., Gordon, M., Corless, C.L. Mod. Pathol. (1997) [Pubmed]
  10. Immunohistochemical and biochemical analysis of a human Sertoli-Leydig cell tumor: autonomous steroid production characteristic of ovarian theca cells. Sawetawan, C., Rainey, W.E., Word, R.A., Carr, B.R. J. Soc. Gynecol. Investig. (1995) [Pubmed]
  11. Hemolytic uremic syndrome in a patient on cis-platinum, vinblastine and bleomycin. van der Meer, J., de Vries, E.G., Vriesendorp, R., Willemse, P.H., Donker, A.J., Aalders, J.G. J. Cancer Res. Clin. Oncol. (1985) [Pubmed]
  12. Steroidogenesis in a virilizing ovarian tumour. Maschler, I., Weidenfeld, J., Fleischer, B., Ehrenfeld, E.N., Finkelstein, M. Clin. Endocrinol. (Oxf) (1975) [Pubmed]
  13. Endocrine studies on ovarian androblastomas (Sertoli-Leydig tumors). Munemura, M., Inoue, S., Himeno, R., Koyama, N., Mizumoto, J., Maeyama, M., Iwamasa, T. J. Endocrinol. Invest. (1984) [Pubmed]
  14. Ovarian and peripheral steroid hormones in a case of Sertoli-Leydig cell tumor. Mango, D., Scirpa, P., Liberati, M., Menini, E., Fabiano, A., Mancuso, S. J. Endocrinol. Invest. (1988) [Pubmed]
  15. Overexpression of the BCL2 gene in a Sertoli-Leydig cell tumor of the ovary: a pathologic and cytogenetic study. Truss, L., Dobin, S.M., Rao, A., Donner, L.R. Cancer Genet. Cytogenet. (2004) [Pubmed]
  16. Steroid receptors and response to hormonal and cytotoxic agents in vitro in two cases of androblastoma. Taina, E., Mäenpää, J., Erkkola, R., Grönroos, M. Annales chirurgiae et gynaecologiae. Supplementum. (1987) [Pubmed]
  17. Ovarian Sertoli-Leydig cell tumor with retiform and heterologous components. Report of a case with hepatocytic differentiation and elevated serum alpha-fetoprotein. Young, R.H., Perez-Atayde, A.R., Scully, R.E. Am. J. Surg. Pathol. (1984) [Pubmed]
  18. Androblastoma and raised serum alpha-fetoprotein with familial multinodular goitre. Case report. O'Brien, P.K. British journal of obstetrics and gynaecology. (1982) [Pubmed]
  19. Relaxin-like factor expression in a human ovarian Sertoli-Leydig cell tumor. Klonisch, T., Hombach-Klonisch, S., Buchmann, J., Fischer, B., Bergmann, M., Steger, K. Fertil. Steril. (1999) [Pubmed]
  20. Ectopic ACTH syndrome due to bilateral ovarian androblastoma with double, gynandroblastic differentiation in one ovary. Kasperlik-Zaluska, A.A., Sikorowa, L., Ploch, E., Soszyński, P., Jeske, W., Migdalska, B., Wysocki, M. Eur. J. Obstet. Gynecol. Reprod. Biol. (1993) [Pubmed]
  21. Sertoli-Leydig cell tumor of the ovary: a case report with endocrinologic observations. Verkauf, B.S., Ruffolo, E. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. (1996) [Pubmed]
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