Disease relevance of Ophthalmia, Sympathetic

• We have investigated whether Vogt-Koyanagi-Harada (VKH) disease and sympathetic ophthalmia (SO), systemic inflammatory disorders affecting various organs containing melanocytes, are autoimmune diseases directed toward the MART-1 antigen [1].
• T cell responses specific for melanoma cells and melanocytes appear to be involved in the rejection of melanoma tumors, as well as in the development of autoimmune reactions in patients with Vogt-Koyanagi-Harada disease (VKH), sympathetic ophthalmia, or autoimmune vitiligo [2].
• Extensive tables elucidate the mechanisms underlying such conditions as, systemic lupus erythematosus, polyarteritis nodosa, Sjögren's syndrome, Wegener's granulomatosis, scleritis, sarcoidosis, Behcet's disease, idiopathic retinal vasculitis, sympathetic ophthalmia, Vogt-Koyanagi-Harada syndrome, and dysthyroid eye disease [3].
• Cyclosporine-induced resolution of choroidal neovascularization associated with sympathetic ophthalmia [4].
• A 78-year-old woman with a recurrent retinal detachment in the right eye presented 2 years after her last surgery with clinical and fluorescein angiographic evidence of sympathetic ophthalmia in the left eye [5].

High impact information on Ophthalmia, Sympathetic

• CONCLUSION: Prompt and aggressive use of antiinflammatory therapy can improve the visual outcome of patients with sympathetic ophthalmia [6].
• Only ten cases of sympathetic ophthalmia with fluorescein angiography have been reported previously [7].
• Sympathetic ophthalmia developed and was controlled with systemic corticosteroids and imuran [8].
• Intravitreal triamcinolone acetonide in sympathetic ophthalmia [9].
• CONCLUSIONS: In this study, short-term improvement in the clinical picture of a patient with sympathetic ophthalmia after intravitreal triamcinolone acetonide injection was described [9].

Chemical compound and disease context of Ophthalmia, Sympathetic

• Chlorambucil therapy in sympathetic ophthalmia [10].
• Sympathetic ophthalmia developed, which responded well to steroid treatment [11].

Gene context of Ophthalmia, Sympathetic

• We studied a patient with clinical features of sympathetic ophthalmia secondary to previous penetrating ocular injuries, and compared the ocular and systemic levels of IL-1 beta and TNF to control serum, and correlated these findings to histopathological sections of the patient's eye [12].
• Nine eyeballs were enucleated from nine patients with excessive myopia, secondary retinochoroidal atrophy, absolute glaucoma, uveal malignant melanoma, Behçet's disease and sympathetic ophthalmia [13].

References