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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Cardiovirus

 
 
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Disease relevance of Cardiovirus

  • We extend these findings by showing that echovirus 22 does not cleave p220, part of the cellular cap-binding complex necessary for cap-dependent translation, suggesting a biology more consistent with cardioviruses than enteroviruses [1].
  • Primary cleavage of the viral polyprotein also occurs at the 2A-2B junction in cardioviruses and aphthoviruses, but assembly of pentamers containing 1D2A has not been reported for those viruses [2].
  • The RNA genome of Theiler's murine encephalomyelitis viruses, a picornavirus belonging to the genus Cardiovirus, is translated in infected cells to a polyprotein [3].
  • However, the vector viruses did not readily revert to the wild-type sequence but rather retained some of the insert plus the artificial 3Cpro/3CDpro cleavage site, engineered between the heterologous sequence and the poliovirus polyprotein, to give rise to genotypes reminiscent of cardioviruses [4].
  • Sikhote-Alin virus, a new member of the cardiovirus group (Picornaviridae) isolated from Ixodes persulcatus ticks in Primorie Region [5].
 

High impact information on Cardiovirus

  • Although guanidine does not inhibit cardiovirus infection, a compound with similar discriminatory characteristics would be experimentally useful for parallel work with these viruses [6].
  • We conclude that dipyridamole is a potent experimental tool that readily distinguishes between cardiovirus translation and RNA replication functions [6].
  • In contrast, stimulation of translation initiation on a cardiovirus IRES by this proteinase was minimal, and stimulation of translation driven from the cognate FMDV IRES could not be evidenced [7].
  • Therefore, at least three antiviral activities against cardioviruses can be distinguished in IFN-treated L cells, and two of them appear not to involve the 2-5A synthetase/RNase L pathway [8].
  • Therefore, the erythrocyte receptor for EV70 is different from that for common enteroviruses and similar, though not identical, to the cardiovirus receptor [9].
 

Chemical compound and disease context of Cardiovirus

 

Gene context of Cardiovirus

  • The large subunit of the complex, eIF4G, is cleaved upon picornavirus (except cardiovirus) infection [11].
  • The IRES elements of entero- and cardioviruses also bind the cellular protein, p52, but the significance of this interaction remains to be shown [12].

References

  1. Cap-binding complex protein p220 is not cleaved during echovirus 22 replication in HeLa cells. Coller, B.G., Tracy, S.M., Etchison, D. J. Virol. (1991) [Pubmed]
  2. Morphogenesis of hepatitis A virus: isolation and characterization of subviral particles. Anderson, D.A., Ross, B.C. J. Virol. (1990) [Pubmed]
  3. Cap-independent translation by the 5' untranslated region of Theiler's murine encephalomyelitis virus. Bandyopadhyay, P.K., Wang, C., Lipton, H.L. J. Virol. (1992) [Pubmed]
  4. Expression of foreign proteins by poliovirus polyprotein fusion: analysis of genetic stability reveals rapid deletions and formation of cardioviruslike open reading frames. Mueller, S., Wimmer, E. J. Virol. (1998) [Pubmed]
  5. Sikhote-Alin virus, a new member of the cardiovirus group (Picornaviridae) isolated from Ixodes persulcatus ticks in Primorie Region. Lvov, D.K., Leonova, G.N., Gromashevsky, V.L., Shestakov, V.L., Gofman, Y.P., Skvortsova, T.M., Klimenko, S.M., Berezina, L.K., Zakaryan, V.A., Safronov, A.V., Belousova, R.V. Acta Virol. (1978) [Pubmed]
  6. Dipyridamole reversibly inhibits mengovirus RNA replication. Fata-Hartley, C.L., Palmenberg, A.C. J. Virol. (2005) [Pubmed]
  7. Foot-and-mouth disease virus Lb proteinase can stimulate rhinovirus and enterovirus IRES-driven translation and cleave several proteins of cellular and viral origin. Ziegler, E., Borman, A.M., Kirchweger, R., Skern, T., Kean, K.M. J. Virol. (1995) [Pubmed]
  8. Dissociable antiviral activities directed against cardioviruses are expressed in L cells treated with interferon. Monahan, S.J., Simon, E. J. Gen. Virol. (1992) [Pubmed]
  9. Neuraminidase-sensitive erythrocyte receptor for enterovirus type 70. Utagawa, E.T., Miyamura, K., Mukoyama, A., Kono, R. J. Gen. Virol. (1982) [Pubmed]
  10. Mechanism of antiviral action of quercetin against cardiovirus infection in mice. Veckenstedt, A., Pusztai, R. Antiviral Res. (1981) [Pubmed]
  11. Adenovirus infection inactivates the translational inhibitors 4E-BP1 and 4E-BP2. Gingras, A.C., Sonenberg, N. Virology (1997) [Pubmed]
  12. Cap-independent translation of picornavirus RNAs: structure and function of the internal ribosomal entry site. Jang, S.K., Pestova, T.V., Hellen, C.U., Witherell, G.W., Wimmer, E. Enzyme (1990) [Pubmed]
 
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