High impact information on Capillary Fragility

• Vitamin C supplementation had little impact on blood glucose concentrations, but was found to lower cellular sorbitol concentrations and to reduce capillary fragility [1].
• With resumption of a normal vitamin C intake, scattered deficiency symptoms disappeared and both capillary fragility tests and serum ascorbic acid levels returned toward normal [2].
• Two limitations for using hypovitaminosis A diets were capillary fragility and a cisterna magna that did not develop to the size of that structure in birds of the same age fed control diets with adequate vitamin A content [3].
• Capillary fragility tended to decrease during GH therapy (p = 0.2) [4].
• Efficacy of topical treatment with aescin + essential phospholipids gel on capillary fragility [5].

Associations of Capillary Fragility with chemical compounds

• A double-blind, placebo-controlled trial of a new veno-active flavonoid fraction (S 5682) in the treatment of symptomatic capillary fragility [6].
• A statistically significant diminution of capillary fragility was also observed in the calcium dobesilate-treated group [7].
• A combination of ascorbate depletion and the injection of foreign proteins can cause a very high blood histamine level, leading to capillary fragility and venular bleeding [8].
• The efficacy and safety of a new veno-active flavonoid fraction (S 5682) consisting of micronized diosmin (90%) and hesperidin (10%) have been studied in 100 patients with symptomatic capillary fragility in a double-blind, randomized, placebo-controlled trial [6].

Gene context of Capillary Fragility

• Capillary fragility in man during exposure to 1-5 ATA air and after decompression from these pressures was studied by means of a petechiometer [9].

Analytical, diagnostic and therapeutic context of Capillary Fragility

• Whole blood ascorbate, plasma oxalate, serum cholesterol, and capillary fragility were measured at monthly intervals for 3 mth in 7 patients receiving continuous ambulatory peritoneal dialysis and 4 receiving haemodialysis, to whom ascorbate supplements had not been prescribed for at least 12 mth [10].

References