High impact information on Para-Aortic Bodies

• In addition to the vascular endothelium, EPAS1 is expressed intensively in the organ of Zuckerkandl (OZ), the principle source of catecholamine production in mammalian embryos [1].
• Norepinephrine-secreting tumor of the organ of Zuckerkandl. Response to propranolol alone [2].
• Phaeochromocytoma of the organ of Zuckerkandl invading inferior vena cava [3].
• The results indicate that in the guinea-pig, in spite of differences in proportions of adrenaline and noradrenaline in the adrenal gland and para-aortic body (PAB), the loss of labelled catecholamines from the innervated PAB closely follows that from the adrenal medulla, suggesting that both participate in normal sympathoadrenal activity [4].
• They are discussed with regard to the life span of the para-aortic body, and their implications are considered in the light of previously reported glucocorticoid-induced transformations of small granule cells from cervical sympathetic ganglia into catecholamine-storing chromaffin cells [5].

Biological context of Para-Aortic Bodies

• Hydrocortisone administration to mice for the last week of gestation also leads to a highly significant increase in the size and the labelling index of the perinatal para-aortic body [6].

Associations of Para-Aortic Bodies with chemical compounds

• In the para-aortic bodies of 14 days old, 21 days old and adult mice, the extra-adrenal chromaffin tissue was too dispersed to obtain values for either volumetric analysis or labelling indices, and hydrocortisone was without significant effect in promoting a hyperplastic response [7].

References