Disease relevance of HIV Wasting Syndrome

• We examined the hypothesis that myostatin expression correlates inversely with fat-free mass in humans and that increased expression of the myostatin gene is associated with weight loss in men with AIDS wasting syndrome [1].
• TNF alpha and IL-1 alpha are thought to contribute to impaired anabolism in a variety of clinical states, including sepsis, cancer cachexia and the AIDS wasting syndrome [2].

High impact information on HIV Wasting Syndrome

• It is unknown whether testosterone deficiency contributes to the profound catabolic state and loss of lean body mass associated with the AIDS wasting syndrome [3].
• Effects of androgen administration in men with the AIDS wasting syndrome. A randomized, double-blind, placebo-controlled trial [3].
• Results suggest an interaction between HIVgp120 and the chemokine system to generate the HIV-wasting syndrome, the motor abnormalities and changes in pain perception [4].
• In children with AIDS wasting syndrome, a low CD4 count and high viral load are likely so that effective antiviral treatment may ultimately produce the greatest improvement in health, including nutritional status [5].
• Ten percent (1 of 10) of sera from Central Africans with 'Slim Disease' were HIV-ag positive [6].

Chemical compound and disease context of HIV Wasting Syndrome

• D-xylose malabsorption: characteristic finding in patients with the AIDS wasting syndrome and chronic diarrhea [7].
• Low dihydrotestosterone and weight loss in the AIDS wasting syndrome [8].

References