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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Animals, Congenic

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High impact information on Animals, Congenic

  • This locus was backcrossed onto the resistant C57BL/6 (B6) background, in the presence or absence of Fas, resulting in the generation of B6.MRLc7 congenic animals [1].
  • Suppression of an IgM PFC response in allotype congenic animals confirms close linkage of the marker to Igh-1 but not to H-2 [2].
  • Congenic animals targeting these regions with F344/NHsd deoxyribonucleic acid on a DA/Bkl genomic background demonstrated corticosterone levels approximating those of F344/NHsd rats and differing significantly from DA/Bkl rats [3].
  • Adenylate cyclase activity and the effects of various activators and inhibitors of this enzyme were measured in retinas from normal mice (C57BL/6J) and congenic animals with photoreceptor dystrophy [4].
  • We studied the effects of a single genetic change on a complex mammalian behavior using animals congenic for two variants of Abpa, the gene for the alpha subunit of mouse salivary androgen-binding protein (ABP), in two-way preference tests [5].

Associations of Animals, Congenic with chemical compounds

  • To further examine the role of specific complement requirement, we initiated the immune complex response in C5-sufficient and C5-deficient congenic animals [6].

Gene context of Animals, Congenic

  • METHODS: Congenic animals were produced by introgressing F344-derived Dmo1 alleles into the OLETF rat [7].
  • Here we generated a series of congenic animals by individually introgressing all 11 OLETF-derived NIDDM loci into a normoglycemic F344 background [8].


  1. The centromeric region of chromosome 7 from MRL mice (Lmb3) is an epistatic modifier of Fas for autoimmune disease expression. Kong, P.L., Morel, L., Croker, B.P., Craft, J. J. Immunol. (2004) [Pubmed]
  2. A mature T lymphocyte marker closely linked to Igh-1 that is expressed on the precursor for the suppressor T cell regulating a primary response to SRBC. Owen, F.L. J. Immunol. (1980) [Pubmed]
  3. Genomic regions controlling corticosterone levels in rats. Potenza, M.N., Brodkin, E.S., Joe, B., Luo, X., Remmers, E.F., Wilder, R.L., Nestler, E.J., Gelernter, J. Biol. Psychiatry (2004) [Pubmed]
  4. Adenylate cyclases in vertebrate retina: enzymatic characteristics in normal and dystrophic mouse retina. Ferrendelli, J.A., Campau, K.M., De Vries, G.W. J. Neurochem. (1982) [Pubmed]
  5. Female preference for male saliva: implications for sexual isolation of Mus musculus subspecies. Talley, H.M., Laukaitis, C.M., Karn, R.C. Evolution (2001) [Pubmed]
  6. Complement-dependent immune complex-induced bronchial inflammation and hyperreactivity. Lukacs, N.W., Glovsky, M.M., Ward, P.A. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
  7. Substitution of Dmo1 with normal alleles results in decreased manifestation of diabetes in OLETF rats. Okuno, S., Kondo, M., Yamasaki, Y., Miyao, H., Ono, T., Iwanaga, T., Omori, K., Okano, M., Suzuki, M., Momota, H., Hishigaki, H., Hayashi, I., Goto, Y., Shinomiya, H., Harada, Y., Hirashima, T., Kanemoto, N., Asai, T., Wakitani, S., Takagi, T., Nakamura, Y., Tanigami, A., Watanabe, T.K. Diabetes, obesity & metabolism. (2002) [Pubmed]
  8. Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats. Kose, H., Moralejo, D.H., Ogino, T., Mizuno, A., Yamada, T., Matsumoto, K. Mamm. Genome (2002) [Pubmed]
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