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MeSH Review:

Central Nervous System Cysts

Lach, B. et al., Lach, B. et al., Oka, H. et al., Abbud, R.A. et al., Krueger, D.W. et al., et al.

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Disease relevance of Central Nervous System Cysts

The high signal intensity in magnetic resonance images of Rathke's cleft cysts may be explained by hemorrhage and a deposition of cholesterol crystal and may be considered in certain cases of Rathke's cleft cyst, especially when they are large [1].
S-100-positive cells were detected in 2 Rathke's cleft cysts, in 2 neurenteric cysts, in 1 colloid cyst, and in 2 choroidal epithelial cysts [2].
Thirteen colloid cysts (CC), four Rathke cleft cysts (RCC), three follicular cysts of normal pituitary gland (FCP), four enterogenous cysts (EC), three normal choroid plexi (CP), three choroid plexus papillomas (CPP), and several samples of normal bronchial mucosa and ependyma were studied by electron microscopy [3].

High impact information on Central Nervous System Cysts

Arrested murine pituitary maturation with formation of pituitary Rathke's cleft cysts, GH deficiency, and short stature provide a model to study human Rathke's cyst pathogenesis [4].
Three head computed tomographic scans, including double contrast with 5-mm cuts, failed to locate the large suprasellar cyst outlined finally by head computed tomographic scan with metrizamide [5].
Transgenic mice overexpressing LIF in the developing pituitary have altered pituitary differentiation with expansion of corticotropes, maintenance of Rathke's cleft cysts, and suppression of all other pituitary cell types [6].
The lining cells and mucin of Rathke's cleft cysts also revealed CA19-9 [7].
MR imaging with gadopentetate dimeglumine does assist in the diagnosis of Rathke cleft cysts [8].

Gene context of Central Nervous System Cysts

Many cells of follicles in the pars intermedia as well as individual cells of five Rathke's cleft cysts were also immunoreactive for chromogranin, S-100 protein, GFAP, and pituitary hormones [9].
Reaction for carcinoembryonic antigen was present on the apical surface of scattered cells of colloid, follicular, and Rathke's cleft cysts [9].
CONCLUSION: Symptomatic Rathke's cleft cysts are rare and can occasionally cause panhypopituitarism [10].

References

Radiological study of symptomatic Rathke's cleft cysts. Oka, H., Kawano, N., Suwa, T., Yada, K., Kan, S., Kameya, T. Neurosurgery (1994) [Pubmed]
Immunohistochemical study of intracranial cysts. Inoue, T., Matsushima, T., Fukui, M., Iwaki, T., Takeshita, I., Kuromatsu, C. Neurosurgery (1988) [Pubmed]
Colloid cyst of the third ventricle: a comparative ultrastructural study of neuraxis cysts and choroid plexus epithelium. Lach, B., Scheithauer, B.W. Ultrastructural pathology. (1992) [Pubmed]
Pituitary-directed leukemia inhibitory factor transgene forms Rathke's cleft cysts and impairs adult pituitary function. A model for human pituitary Rathke's cysts. Akita, S., Readhead, C., Stefaneanu, L., Fine, J., Tampanaru-Sarmesiu, A., Kovacs, K., Melmed, S. J. Clin. Invest. (1997) [Pubmed]
Recurrent fever of unknown origin, coma, and meningismus due to a leaking craniopharyngioma. Krueger, D.W., Larson, E.B. Am. J. Med. (1988) [Pubmed]
Cell-specific pituitary gene expression profiles after treatment with leukemia inhibitory factor reveal novel modulators for proopiomelanocortin expression. Abbud, R.A., Kelleher, R., Melmed, S. Endocrinology (2004) [Pubmed]
Carbohydrate antigen 19-9 expression by folliculo-tubular structures of normal and neoplastic pituitary. Okubo, T., Okabe, H. Acta Neuropathol. (1997) [Pubmed]
Rathke cleft cysts: correlation of enhanced MR and surgical findings. Sumida, M., Uozumi, T., Mukada, K., Arita, K., Kurisu, K., Eguchi, K. AJNR. American journal of neuroradiology. (1994) [Pubmed]
Colloid cyst of the third ventricle. A comparative immunohistochemical study of neuraxis cysts and choroid plexus epithelium. Lach, B., Scheithauer, B.W., Gregor, A., Wick, M.R. J. Neurosurg. (1993) [Pubmed]
Panhypopituitarism due to pituitary cyst of Rathke's cleft origin--two case reports. Mukherjee, J.J., Lee, C.H., Ong, P.L., Teo, J. Ann. Acad. Med. Singap. (2001) [Pubmed]

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