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MeSH Review:

Neuromuscular Junction Diseases

Flagstad, A. et al., Gajdos, P. et al., Girlanda, P. et al.

Gajdos, Chevret, Toyka,

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High impact information on Neuromuscular Junction Diseases

Ampicillin is considered a 'safe' drug in patients with neuromuscular transmission disorders although recently some doubt has been raised [1].
In up to 90 per cent of cases IgG autoantibodies to the nicotinic acetylcholine receptor are detectable which mediate the neuromuscular transmission disorder [2].
The pharmacokinetic parameters of guanidine hydrochloride were analysed in dogs with an hereditary neuromuscular transmission disorder by the use of 14C-guanidine hydrochloride [3].

References

Effect of ampicillin on neuromuscular transmission in healthy men: a single-fiber electromyographic study. Girlanda, P., Venuto, C., Mangiapane, R. Eur. Neurol. (1989) [Pubmed]
Intravenous immunoglobulin for myasthenia gravis. Gajdos, P., Chevret, S., Toyka, K. Cochrane database of systematic reviews (Online) (2003) [Pubmed]
Pharmacokinetics and pharmacodynamics of guanidine hydrochloride in an hereditary myasthenia gravis-like disorder in dogs. Flagstad, A., Nielsen, P., Trojaborg, W. J. Vet. Pharmacol. Ther. (1986) [Pubmed]

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