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Disease relevance of Stenotrophomonas


High impact information on Stenotrophomonas


Chemical compound and disease context of Stenotrophomonas


Biological context of Stenotrophomonas


Anatomical context of Stenotrophomonas


Gene context of Stenotrophomonas

  • Mutations in gyrA and parC QRDRs are not relevant for quinolone resistance in epidemiological unrelated Stenotrophomonas maltophilia clinical isolates [22].
  • Here the authors show that the surfactant protein (SP) SP-D, but not SP-A, agglutinates some clinical isolates of Pseudomonas aeruginosa and Stenotrophomonas maltophilia [23].
  • It is uncommon for these common bacteria, except MRSA and Stenotrophomonas maltophilia, to be resistant to meropenem in Taiwan, where a high prevalence of resistance to other antimicrobial agents was found in many of the common bacteria [24].
  • SmeDEF multidrug efflux pump contributes to intrinsic multidrug resistance in Stenotrophomonas maltophilia [25].
  • 6. Sequencing revealed that FEZ-1 is a molecular-class B beta-lactamase which shares the closest structural similarity (29.7% of identical residues) with the L1 enzyme of Stenotrophomonas maltophilia, being a new member of the highly divergent subclass B3 lineage [26].

Analytical, diagnostic and therapeutic context of Stenotrophomonas


  1. A melanin pigment purified from an epidemic strain of Burkholderia cepacia attenuates monocyte respiratory burst activity by scavenging superoxide anion. Zughaier, S.M., Ryley, H.C., Jackson, S.K. Infect. Immun. (1999) [Pubmed]
  2. Lipopolysaccharide (LPS) from Burkholderia cepacia is more active than LPS from Pseudomonas aeruginosa and Stenotrophomonas maltophilia in stimulating tumor necrosis factor alpha from human monocytes. Zughaier, S.M., Ryley, H.C., Jackson, S.K. Infect. Immun. (1999) [Pubmed]
  3. Levofloxacin and ciprofloxacin in vitro activities against 4,003 clinical bacterial isolates collected in 24 Italian laboratories. Gesu, G.P., Marchetti, F., Piccoli, L., Cavallero, A. Antimicrob. Agents Chemother. (2003) [Pubmed]
  4. In vitro bactericidal activity of human beta-defensin 3 against multidrug-resistant nosocomial strains. Maisetta, G., Batoni, G., Esin, S., Florio, W., Bottai, D., Favilli, F., Campa, M. Antimicrob. Agents Chemother. (2006) [Pubmed]
  5. Antimicrobial peptide therapeutics for cystic fibrosis. Zhang, L., Parente, J., Harris, S.M., Woods, D.E., Hancock, R.E., Falla, T.J. Antimicrob. Agents Chemother. (2005) [Pubmed]
  6. Novel mechanism of hydrolysis of therapeutic beta-lactams by Stenotrophomonas maltophilia L1 metallo-beta-lactamase. Spencer, J., Clarke, A.R., Walsh, T.R. J. Biol. Chem. (2001) [Pubmed]
  7. Three-dimensional structure of FEZ-1, a monomeric subclass B3 metallo-beta-lactamase from Fluoribacter gormanii, in native form and in complex with D-captopril. García-Sáez, I., Mercuri, P.S., Papamicael, C., Kahn, R., Frère, J.M., Galleni, M., Rossolini, G.M., Dideberg, O. J. Mol. Biol. (2003) [Pubmed]
  8. The crystal structure of the L1 metallo-beta-lactamase from Stenotrophomonas maltophilia at 1.7 A resolution. Ullah, J.H., Walsh, T.R., Taylor, I.A., Emery, D.C., Verma, C.S., Gamblin, S.J., Spencer, J. J. Mol. Biol. (1998) [Pubmed]
  9. The biocide triclosan selects Stenotrophomonas maltophilia mutants that overproduce the SmeDEF multidrug efflux pump. Sanchez, P., Moreno, E., Martinez, J.L. Antimicrob. Agents Chemother. (2005) [Pubmed]
  10. Antifolate activity of epigallocatechin gallate against Stenotrophomonas maltophilia. Navarro-Martínez, M.D., Navarro-Perán, E., Cabezas-Herrera, J., Ruiz-Gómez, J., García-Cánovas, F., Rodríguez-López, J.N. Antimicrob. Agents Chemother. (2005) [Pubmed]
  11. Topoisomerase II and IV quinolone resistance-determining regions in Stenotrophomonas maltophilia clinical isolates with different levels of quinolone susceptibility. Valdezate, S., Vindel, A., Echeita, A., Baquero, F., Cantó, R. Antimicrob. Agents Chemother. (2002) [Pubmed]
  12. Biofilm formation by Stenotrophomonas maltophilia: modulation by quinolones, trimethoprim-sulfamethoxazole, and ceftazidime. Di Bonaventura, G., Spedicato, I., D'Antonio, D., Robuffo, I., Piccolomini, R. Antimicrob. Agents Chemother. (2004) [Pubmed]
  13. In vitro activity of BAY 12-8039, a new fluoroquinolone. Woodcock, J.M., Andrews, J.M., Boswell, F.J., Brenwald, N.P., Wise, R. Antimicrob. Agents Chemother. (1997) [Pubmed]
  14. Activities of ciprofloxacin and moxifloxacin against Stenotrophomonas maltophilia and emergence of resistant mutants in an in vitro pharmacokinetic-pharmacodynamic model. Ba, B.B., Feghali, H., Arpin, C., Saux, M.C., Quentin, C. Antimicrob. Agents Chemother. (2004) [Pubmed]
  15. Antimicrobial activities of gatifloxacin against nosocomial isolates of Stenotrophomonas maltophilia measured by MIC and time-kill studies. Cohn, M.L., Waites, K.B. Antimicrob. Agents Chemother. (2001) [Pubmed]
  16. Sequence analysis and enzyme kinetics of the L2 serine beta-lactamase from Stenotrophomonas maltophilia. Walsh, T.R., MacGowan, A.P., Bennett, P.M. Antimicrob. Agents Chemother. (1997) [Pubmed]
  17. Role of phosphoglucomutase of Stenotrophomonas maltophilia in lipopolysaccharide biosynthesis, virulence, and antibiotic resistance. McKay, G.A., Woods, D.E., MacDonald, K.L., Poole, K. Infect. Immun. (2003) [Pubmed]
  18. SmeC, an outer membrane multidrug efflux protein of Stenotrophomonas maltophilia. Li, X.Z., Zhang, L., Poole, K. Antimicrob. Agents Chemother. (2002) [Pubmed]
  19. Plasmid location and molecular heterogeneity of the L1 and L2 beta-lactamase genes of Stenotrophomonas maltophilia. Avison, M.B., Higgins, C.S., von Heldreich, C.J., Bennett, P.M., Walsh, T.R. Antimicrob. Agents Chemother. (2001) [Pubmed]
  20. Structure of the O6 antigen of Stenotrophomonas (Xanthomonas or Pseudomonas) maltophilia. Winn, A.M., Wilkinson, S.G. Carbohydr. Res. (1995) [Pubmed]
  21. Risk factors for emergence of Stenotrophomonas maltophilia in cystic fibrosis. Talmaciu, I., Varlotta, L., Mortensen, J., Schidlow, D.V. Pediatr. Pulmonol. (2000) [Pubmed]
  22. Mutations in gyrA and parC QRDRs are not relevant for quinolone resistance in epidemiological unrelated Stenotrophomonas maltophilia clinical isolates. Ribera, A., Doménech-Sanchez, A., Ruiz, J., Benedi, V.J., Jimenez de Anta, M.T., Vila, J. Microb. Drug Resist. (2002) [Pubmed]
  23. Cytokine stimulation by Pseudomonas aeruginosa--strain variation and modulation by pulmonary surfactant. Bufler, P., Schikor, D., Schmidt, B., Griese, M. Exp. Lung Res. (2004) [Pubmed]
  24. In vitro activity of meropenem against common pathogenic bacteria isolated in Taiwan. Chang, S.C., Fang, C.T., Chen, Y.C., Hsueh, P.R., Luh, K.T., Hsieh, W.C. Diagn. Microbiol. Infect. Dis. (1998) [Pubmed]
  25. SmeDEF multidrug efflux pump contributes to intrinsic multidrug resistance in Stenotrophomonas maltophilia. Zhang, L., Li, X.Z., Poole, K. Antimicrob. Agents Chemother. (2001) [Pubmed]
  26. The Legionella (Fluoribacter) gormanii metallo-beta-lactamase: a new member of the highly divergent lineage of molecular-subclass B3 beta-lactamases. Boschi, L., Mercuri, P.S., Riccio, M.L., Amicosante, G., Galleni, M., Frère, J.M., Rossolini, G.M. Antimicrob. Agents Chemother. (2000) [Pubmed]
  27. Comparison of treatment with imipenem vs. ceftazidime as a predisposing factor for nosocomial acquisition of Stenotrophomonas maltophilia: a historical cohort study. Carmeli, Y., Samore, M.H. Clin. Infect. Dis. (1997) [Pubmed]
  28. Molecular identification of a Stenotrophomonas species used in the bioassay for erythromycin in aquaculture samples. Wang, R.F., Pothuluri, J.V., Steele, R.S., Paine, D.D., Assaf, N.A., Cerniglia, C.E. Mol. Cell. Probes (1998) [Pubmed]
  29. Analysis of TNT (2,4,6-trinitrotoluene)-inducible cellular responses and stress shock proteome in Stenotrophomonas sp. OK-5. Ho, E.M., Chang, H.W., Kim, S.I., Kahng, H.Y., Oh, K.H. Curr. Microbiol. (2004) [Pubmed]
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