Disease relevance of Nucleic Acid Amplification Techniques

• Inactivation of the virus has proved difficult and as a consequence, manufacturers of blood products have implemented screening measures to reduce the load of parvovirus B19 in manufacturing plasma pools by the use of nucleic acid amplification techniques (NAT) [1].

High impact information on Nucleic Acid Amplification Techniques

• The RNA amplification technique was used to examine the pattern of coexpression of mRNAs encoding 16 subtypes/subunits of the glutamate receptor (GluR) in acutely dissociated neurons from adult rat striata [2].
• Polymerase chain reaction and other DNA amplification techniques to identify elusive infections should prove to be an effective tool for the clinical and investigative rheumatologist [3].
• To further reduce the risks of transfusion-associated hepatitis will require the enhanced sensitivity provided by nucleic acid amplification techniques (e.g. polymerase chain reaction) [4].
• Use of the direct RNA amplification technique NASBA to detect factor V Leiden, a point mutation associated with APC resistance [5].
• Using DNA amplification techniques, which are sensitive and specific, such as the one described in this paper, sera and other biological fluids and tissues from different animal species should be utilized for detecting additional reservoirs for leishmania parasites particularly in known endemic areas of the world [6].

Gene context of Nucleic Acid Amplification Techniques

• Establishment of the first World Health Organization International Standard for human parvovirus B19 DNA nucleic acid amplification techniques [7].

Analytical, diagnostic and therapeutic context of Nucleic Acid Amplification Techniques

• A further improvement of the laboratory diagnosis of tuberculosis is expected in the near future by nucleic acid amplification techniques (polymerase chain reaction and others) [8].

References