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MeSH Review:

Latex Hypersensitivity

Posch, A. et al., Lehto, M. et al., McCleskey, P.E. et al., Lehto, M. et al., von Hintzenstern, J. et al., et al.

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Disease relevance of Latex Hypersensitivity

As respiratory symptoms are common in addition to skin reactions in natural rubber latex allergy, we investigated the significance of different allergen exposure routes in the development of lung inflammation and airway hyperreactivity (AHR) [1].
In addition to immediate type I allergy symptoms, natural rubber latex allergy may manifest as protein contact dermatitis on the hands of health-care workers and other natural rubber latex glove users [2].
On the other hand, more than 50% of subjects having IgE-mediated natural rubber latex allergy are sensitized to avocado fruit as demonstrated by skin-prick testing and/or specific IgE measurements and about 10-20% report hypersensitivity reactions after ingesting avocado [3].
There has been a particular increase in severe allergic disease, including anaphylaxis, food, drug and latex rubber allergy [4].
A strong connection between food allergy and natural rubber latex allergy is recognized and described in this review [5].

High impact information on Latex Hypersensitivity

OBJECTIVE: To summarize the clinical symptoms of latex rubber allergy and provide guidelines for the management of this allergy [6].
Diagnosis of natural rubber latex allergy: multicenter latex skin testing efficacy study. Multicenter Latex Skin Testing Study Task Force [7].
The number of surgical interventions correlates strongly with the presence of natural rubber latex allergy (P<0.0002), independent of age, sex and presence of atopy [8].
Serologic methods in the laboratory diagnosis of latex rubber allergy: study of nonammoniated, ammoniated latex, and glove (end-product) extracts as allergen reagent sources [9].
Patch tests revealed thiuram-mix (62%) as the most commonly positive rubber-mix but, in contrast to the group with glove-induced rubber allergy, black-rubber-mix came second (38%) [10].

Chemical compound and disease context of Latex Hypersensitivity

IGE-mediated natural rubber latex allergy: an update [11].
Thioureas--most notably diethylthiourea, dibutylthiourea, and diphenylthiourea--should be considered in individuals with potential rubber allergy who fail to react to antigens in the standard allergen patch test tray [12].

Gene context of Latex Hypersensitivity

Contact allergy in children. Part I: Rubber allergy [13].
Rubber mixes, especially thiuram and PPD mix appeared to be better screening agents than any individual chemical to detect rubber allergy [14].
The new M40/42 series protective mask has a different composition, and should be tried as an alternative to the M17 mask in service members with black rubber allergies [15].

Analytical, diagnostic and therapeutic context of Latex Hypersensitivity

Nasal provocation test in the diagnosis of natural rubber latex allergy [16].

References

Cutaneous, but not airway, latex exposure induces allergic lung inflammation and airway hyperreactivity in mice. Lehto, M., Haapakoski, R., Wolff, H., Majuri, M.L., Mäkelä, M.J., Leino, M., Reunala, T., Turjanmaa, K., Palosuo, T., Alenius, H. J. Invest. Dermatol. (2005) [Pubmed]
Epicutaneous natural rubber latex sensitization induces T helper 2-type dermatitis and strong prohevein-specific IgE response. Lehto, M., Koivuluhta, M., Wang, G., Amghaiab, I., Majuri, M.L., Savolainen, K., Turjanmaa, K., Wolff, H., Reunala, T., Lauerma, A., Palosuo, T., Alenius, H. J. Invest. Dermatol. (2003) [Pubmed]
Class I endochitinase containing a hevein domain is the causative allergen in latex-associated avocado allergy. Posch, A., Wheeler, C.H., Chen, Z., Flagge, A., Dunn, M.J., Papenfuss, F., Raulf-Heimsoth, M., Baur, X. Clin. Exp. Allergy (1999) [Pubmed]
Provision of allergy care for optimal outcome in the UK. Ewan, P.W. Br. Med. Bull. (2000) [Pubmed]
The latex and food allergy connection. Perkin, J.E. Journal of the American Dietetic Association. (2000) [Pubmed]
Allergy to latex rubber. Sussman, G.L., Beezhold, D.H. Ann. Intern. Med. (1995) [Pubmed]
Diagnosis of natural rubber latex allergy: multicenter latex skin testing efficacy study. Multicenter Latex Skin Testing Study Task Force. Hamilton, R.G., Adkinson, N.F. J. Allergy Clin. Immunol. (1998) [Pubmed]
Determination of independent risk factors and comparative analysis of diagnostic methods for immediate type latex allergy in spina bifida patients. De Swert, L.F., Van Laer, K.M., Verpoorten, C.M., Van Hoeyveld, E.M., Cadot, P., Stevens, E.A. Clin. Exp. Allergy (1997) [Pubmed]
Serologic methods in the laboratory diagnosis of latex rubber allergy: study of nonammoniated, ammoniated latex, and glove (end-product) extracts as allergen reagent sources. Hamilton, R.G., Charous, B.L., Adkinson, N.F., Yunginger, J.W. J. Lab. Clin. Med. (1994) [Pubmed]
Frequency, spectrum and occupational relevance of type IV allergies to rubber chemicals. von Hintzenstern, J., Heese, A., Koch, H.U., Peters, K.P., Hornstein, O.P. Contact Derm. (1991) [Pubmed]
IGE-mediated natural rubber latex allergy: an update. Ebo, D.G., Stevens, W.J. Acta clinica Belgica. (2002) [Pubmed]
Clinical review: thioureas and allergic contact dermatitis. McCleskey, P.E., Swerlick, R.A. Cutis; cutaneous medicine for the practitioner. (2001) [Pubmed]
Contact allergy in children. Part I: Rubber allergy. Fisher, A.A. Cutis; cutaneous medicine for the practitioner. (1994) [Pubmed]
Sensitivity to rubber. Study with rubber mixes and individual rubber chemicals. Lammintausta, K., Kalimo, K. Dermatosen in Beruf und Umwelt. Occupation and environment. (1985) [Pubmed]
Contact urticaria to the M17 protective mask. Pope, R.W., Hill, J.C., Blaskis, M.G. Military medicine. (1995) [Pubmed]
Nasal provocation test in the diagnosis of natural rubber latex allergy. Palczynski, C., Walusiak, J., Ruta, U., Gorski, P. Allergy (2000) [Pubmed]

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