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MeSH Review

Directly Observed Therapy

 
 
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Disease relevance of Directly Observed Therapy

  • CONCLUSIONS: Treatment completion rates for pulmonary tuberculosis are most likely to exceed 90%, as recommended by the Centers for Disease Control and Prevention, when treatment is based on a patient-centered approach using directly observed therapy with multiple enablers and enhancers [1].
  • The objective of this prospective, observational clinical study was to evaluate the safety and efficacy of once-daily and twice-daily directly observed therapy (DOT) in human immunodeficiency virus (HIV)-infected patients undergoing methadone treatment [2].
  • Single-dose azithromycin (30 mg/kg) represents an alternative for the treatment of pediatric patients with uncomplicated acute otitis media, particularly in those geographic regions where high-level S. pneumoniae macrolide resistance is uncommon, and for those patients that require directly observed therapy or when compliance may be a problem [3].
 

High impact information on Directly Observed Therapy

 

Associations of Directly Observed Therapy with chemical compounds

 

Gene context of Directly Observed Therapy

  • After six months of directly observed therapy (DOT), seven patients who were non-responders to a second line antitubercular therapy were given an IFN-alpha aerosol (3 MU, three times a week) for two months as adjunctive therapy [11].
  • In view of the global emergency of tuberculosis, the WHO 'Stop TB' campaign has called for the universal adoption of its directly observed therapy, short course (DOTS) strategy [12].
  • SETTING: A voluntary community health worker programme, in the Western Cape, South Africa, utilizing volunteers to administer directly observed therapy to tuberculosis (TB) patients [13].
 

Analytical, diagnostic and therapeutic context of Directly Observed Therapy

References

  1. Directly observed therapy for treatment completion of pulmonary tuberculosis: Consensus Statement of the Public Health Tuberculosis Guidelines Panel. Chaulk, C.P., Kazandjian, V.A. JAMA (1998) [Pubmed]
  2. Directly observed therapy for the management of HIV-infected patients in a methadone program. Conway, B., Prasad, J., Reynolds, R., Farley, J., Jones, M., Jutha, S., Smith, N., Mead, A., DeVlaming, S. Clin. Infect. Dis. (2004) [Pubmed]
  3. Single-dose azithromycin for the treatment of children with acute otitis media. Soley, C.A., Arguedas, A. Expert review of anti-infective therapy. (2005) [Pubmed]
  4. Nationwide survey of drug-resistant tuberculosis in the United States. Bloch, A.B., Cauthen, G.M., Onorato, I.M., Dansbury, K.G., Kelly, G.D., Driver, C.R., Snider, D.E. JAMA (1994) [Pubmed]
  5. Saquinavir: a review of its use in boosted regimens for treating HIV infection. Plosker, G.L., Scott, L.J. Drugs (2003) [Pubmed]
  6. Chloroquine-resistant Plasmodium vivax malaria in Peru. Ruebush, T.K., Zegarra, J., Cairo, J., Andersen, E.M., Green, M., Pillai, D.R., Marquiño, W., Huilca, M., Arévalo, E., Garcia, C., Solary, L., Kain, K.C. Am. J. Trop. Med. Hyg. (2003) [Pubmed]
  7. Comparative roles of levofloxacin and ofloxacin in the treatment of multidrug-resistant tuberculosis: preliminary results of a retrospective study from Hong Kong. Yew, W.W., Chan, C.K., Leung, C.C., Chau, C.H., Tam, C.M., Wong, P.C., Lee, J. Chest (2003) [Pubmed]
  8. Predictors of adherence to tuberculosis treatment in a supervised therapy programme for prisoners before and after release. Study Group of Adherence to Tuberculosis Treatment of Prisoners. Marco, A., Caylà, J.A., Serra, M., Pedro, R., Sanrama, C., Guerrero, R., Ribot, N. Eur. Respir. J. (1998) [Pubmed]
  9. Which treatment for genital tract Chlamydia trachomatis infection? Tobin, J.M., Harindra, V., Mani, R. International journal of STD & AIDS. (2004) [Pubmed]
  10. Directly observed therapy for the treatment of tuberculosis--evidence based dosage guidelines. Bednall, R., Dean, G., Bateman, N. Respiratory medicine. (1999) [Pubmed]
  11. Aerosolized interferon-alpha treatment in patients with multi-drug-resistant pulmonary tuberculosis. Giosuè, S., Casarini, M., Ameglio, F., Zangrilli, P., Palla, M., Altieri, A.M., Bisetti, A. Eur. Cytokine Netw. (2000) [Pubmed]
  12. The global emergency of tuberculosis: what is the cause? Grange, J.M., Zumla, A. Journal of the Royal Society of Health. (2002) [Pubmed]
  13. Tuberculosis in the community: 2. The perceptions of members of a tuberculosis health team towards a voluntary health worker programme. Dick, J., Schoeman, J.H. Tuber. Lung Dis. (1996) [Pubmed]
  14. Monthly antibiotic chemoprophylaxis and incidence of sexually transmitted infections and HIV-1 infection in Kenyan sex workers: a randomized controlled trial. Kaul, R., Kimani, J., Nagelkerke, N.J., Fonck, K., Ngugi, E.N., Keli, F., MacDonald, K.S., Maclean, I.W., Bwayo, J.J., Temmerman, M., Ronald, A.R., Moses, S. JAMA (2004) [Pubmed]
 
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