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MeSH Review

Curcuma

 
 
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High impact information on Curcuma

  • Curcumin, a chemical compound derived from the curry spice tumeric, releases the ER-retained MPZ mutants into the cytoplasm accompanied by a lower number of apoptotic cells [1].
  • The natural occurring pigment curcumin, a major component of the spice tumeric, has been described to have antioxidative, anti-tumorpromoting, anti-thrombotic and anti-inflammatory properties [2].
  • In this study, we investigated the mechanisms underlying the neuroprotective effects of curcumin, a potent polyphenol antioxidant enriched in tumeric [3].
  • The turmeric peptide (Tp) was isolated from the aqueous turmeric extract of the turmeric rhizome [4].
  • An experiment was conducted in order to study the hypocholesteremic effect of tumeric and its coloring principle namely curcumin both in the presence and absence of dietary cholesterol [5].
 

Biological context of Curcuma

 

Anatomical context of Curcuma

 

Associations of Curcuma with chemical compounds

  • There is a body of literature that suggests that compounds in wine, tumeric, and tea inhibit cyclooxygenases, thus reducing prostaglandin-mediated effects on the colon [7].
  • Curcumin removed turmeric oleoresin (CRTO) was extracted with hexane concentrated to get turmeric oil, and that was fractionated using silica gel column chromatography to obtain three fractions [8].
  • Curcuminoids are components of tumeric, which include mainly curcumin (diferuloyl methane), demethoxycurcumin, and bisdemethoxycurcmin [9].
  • Male Wistar rats were fed MMI, MMI plus vitamin C, MMI plus vitamin E and MMI plus turmeric extract (TE) supplemented diet [10].

References

  1. Curcumin treatment abrogates endoplasmic reticulum retention and aggregation-induced apoptosis associated with neuropathy-causing myelin protein zero-truncating mutants. Khajavi, M., Inoue, K., Wiszniewski, W., Ohyama, T., Snipes, G.J., Lupski, J.R. Am. J. Hum. Genet. (2005) [Pubmed]
  2. The dietary pigment curcumin reduces endothelial tissue factor gene expression by inhibiting binding of AP-1 to the DNA and activation of NF-kappa B. Bierhaus, A., Zhang, Y., Quehenberger, P., Luther, T., Haase, M., Müller, M., Mackman, N., Ziegler, R., Nawroth, P.P. Thromb. Haemost. (1997) [Pubmed]
  3. Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficits. Wang, Q., Sun, A.Y., Simonyi, A., Jensen, M.D., Shelat, P.B., Rottinghaus, G.E., MacDonald, R.S., Miller, D.K., Lubahn, D.E., Weisman, G.A., Sun, G.Y. J. Neurosci. Res. (2005) [Pubmed]
  4. Syntheses of Curcumin Bioconjugates and Study of Their Antibacterial Activities against beta-Lactamase-Producing Microorganisms. Kumar, S., Narain, U., Tripathi, S., Misra, K. Bioconjug. Chem. (2001) [Pubmed]
  5. The influence of turmeric and curcumin on cholesterol concentration of eggs and tissues. Keshavarz, K. Poult. Sci. (1976) [Pubmed]
  6. Cytoprotective effect of curcumin in human proximal tubule epithelial cells exposed to shiga toxin. Sood, A., Mathew, R., Trachtman, H. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  7. Colon cancer chemoprevention with ginseng and other botanicals. Wargovich, M.J. J. Korean Med. Sci. (2001) [Pubmed]
  8. Evaluation of antioxidant activities and antimutagenicity of turmeric oil: a byproduct from curcumin production. Jayaprakasha, G.K., Jena, B.S., Negi, P.S., Sakariah, K.K. Z. Naturforsch., C, J. Biosci. (2002) [Pubmed]
  9. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). Chainani-Wu, N. Journal of alternative and complementary medicine (New York, N.Y.) (2003) [Pubmed]
  10. Effect of antioxidants (vitamin C, E and turmeric extract) on methimazole induced hypothyroidism in rats. Deshpande, U.R., Joseph, L.J., Patwardhan, U.N., Samuel, A.M. Indian J. Exp. Biol. (2002) [Pubmed]
 
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