Disease relevance of Diospyros

• RESULTS: Oral administration of persimmon leaf extract (250 mg kg(-1)) or astragalin (1.5 mg kg-1) for 4 weeks into NC/Nga mice with overt dermatitis resulted in a decrease in the severity of the condition [1].
• Engineered sorbitol accumulation induces dwarfism in Japanese persimmon [2].
• During this investigation, a methanol extract from the twigs of Diospyros lycioides, a Namibia tooth cleaning stick, demonstrated antimicrobial activity against common oral pathogens including Streptococcus mutans and Porphyromonas gingivalis (MICs 2.5 and 0.156 mg/mL) [3].
• A preliminary study on toxicity of diospyrol and oxidized diospyrol from Diospyros mollis Griff. (Maklua) in rabbits eyes [4].
• We have investigated the effects of persimmon (Diospyros kaki) extract (PS) and related polyphenol compounds such as catechin (C), epicatechin (EC), epicatechingallate (ECG), epigallocatechin (EGC), and epigallocatechingallate (EGCG) on the growth of human lymphoid leukemia Molt 4B cells [5].

High impact information on Diospyros

• Ethylene biosynthesis in detached young persimmon fruit is initiated in calyx and modulated by water loss from the fruit [6].
• To investigate ethylene induction mechanisms in detached young persimmon fruit, we cloned three cDNAs encoding 1-aminocyclopropane-1-carboxylic acid (ACC) synthase (DK-ACS1, 2, and -3) and two encoding ACC oxidase (DK-ACO1 and -2) genes involved in ethylene biosynthesis, and we analyzed their expression in various fruit tissues [6].
• These results indicate that ethylene biosynthesis in detached young persimmon fruit is initially induced in calyx and is modulated by water loss through transcriptional activation of DK-ACS2 [6].
• EAST and immunoblot inhibitions were carried out with persimmon; birch, grass, and ragweed pollen; latex; and N-glycans as inhibitors [7].
• Allergy caused by ingestion of persimmon (Diospyros kaki): detection of specific IgE and cross-reactivity to profilin and carbohydrate determinants [7].

Biological context of Diospyros

• Persimmon (Diospyros kaki Thunb.) fruit are usually classified as climacteric fruit; however, unlike typical climacteric fruits, persimmon fruit exhibit a unique characteristic in that the younger the stage of fruit detached, the greater the level of ethylene produced [6].
• Dietary persimmon improves lipid metabolism in rats fed diets containing cholesterol [8].
• Persimmon tannin inhibited lipid peroxidation similarly to (-)-epigallocatechin [9].

Anatomical context of Diospyros

• BACKGROUND: We previously found that persimmon leaf extract contains antiallergic substances that inhibit histamine release by human basophilic cell line KU812 in response to cross-linkage of FcepsilonRI [10].
• Moreover, persimmon extract inhibited [3H]thymidine incorporation of human peripheral lymphocyte cells stimulated by PHA [11].
• It was found that persimmon extract, epigallocatechin gallate, and epicatechin gallate strongly inhibited the activity of DNA polymerase alpha purified from calf thymus [11].

Associations of Diospyros with chemical compounds

• RESULTS: Persimmon leaf extract or astragalin inhibited histamine release from KU812 in response to cross-linkage of FcepsilonRI [10].
• To the basal diet were added 7 g/100 g dry persimmon (Pers), 1 g/100 g cholesterol (Chol), or both (Chol/Pers) [8].
• Isodiospyrin is a natural product from the plant Diospyros morrisiana, which consists of an asymmetrical 1,2-binaphthoquinone chromophore [12].
• We have purified a 27 kDa protein from the overripe fruits of Diospyros texana to homogeneity by ammonium sulfate precipitation, DEAE-Sepharose and C18 reversed phase column chromatographies [13].
• Three triterpenes were isolated from Diospyros leucomelas and identified as betulin, betulinic acid, and ursolic acid [14].

Gene context of Diospyros

• The phytopathogenic fungus Alternaria alternata produces one endo-1,4-beta-glucanase, AaK1, which is an important factor in disease development in persimmon fruit [15].
• Persimmon fruit polyphenol oxidase (PPO) was partially purified using a combination of phase partitioning with Triton X-114 and ammonium sulfate fractionation between 50 and 75% [16].
• The Ki value of DNA polymerase alpha for persimmon extract was estimated to be 70 nM [11].
• Also the antioxidant potential in fresh persimmon as determined by all three used tests was higher than in dried fruit, but not significantly (P > 0.05) [17].
• Pheophorbide A-methyl ester, Acyl-CoA: cholesterol acyltransferase inhibitor from Diospyros kaki [18].

Analytical, diagnostic and therapeutic context of Diospyros

• Three electroantennogram (EAG)-active components were detected by gas chromatography coupled to an electroantennographic detector (GC-EAD) analysis of a hexane extract of the pheromone glands of the persimmon fruit moth, Stathmopoda masinissa [19].
• METHODS: Persimmon leaves were obtained, extracted with 80% ethanol, and isolated into PFs I, II, and III after column chromatography using a Sephadex LH-20 column followed by thin-layer chromatography [20].
• Prolongation of life span of stroke-prone spontaneously hypertensive rats (SHRSP) ingesting persimmon tannin [9].

References