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Disease relevance of Cimicifuga


High impact information on Cimicifuga

  • An isopropanolic extract (iCR) from the rhizomes of Cimicifuga racemosa (black cohosh) is used an alternative in the treatment of menopausal symptoms, and animal studies suggest positive skeletal effects. iCR stimulated osteoblastic OPG protein secretion by 3- to 5-fold as early as 12 h without affecting RANKL expression [3].
  • The iCR effect, abrogated by the pure estrogen receptor antagonist ICI 182,780, also enhanced ALP activity (4-fold) and osteocalcin expression (3-fold), possibly contributing to the skeletal effects of black cohosh [3].
  • Kava kava and black cohosh may interact with CYP2E1 and CYP2D6 substrates, respectively [4].
  • Chaste tree berry, black cohosh, and dong quai did not have measurable activity with this method [5].
  • Further studies are needed to fully characterize whether these triterpene glycosides as well as other components of black cohosh in this plant extract bind to the estrogen receptor alpha (ER-alpha) [6].

Chemical compound and disease context of Cimicifuga


Biological context of Cimicifuga


Anatomical context of Cimicifuga


Associations of Cimicifuga with chemical compounds


Gene context of Cimicifuga


Analytical, diagnostic and therapeutic context of Cimicifuga


  1. Randomized trial of black cohosh for the treatment of hot flashes among women with a history of breast cancer. Jacobson, J.S., Troxel, A.B., Evans, J., Klaus, L., Vahdat, L., Kinne, D., Lo, K.M., Moore, A., Rosenman, P.J., Kaufman, E.L., Neugut, A.I., Grann, V.R. J. Clin. Oncol. (2001) [Pubmed]
  2. Analysis of thirteen populations of black cohosh for formononetin. Kennelly, E.J., Baggett, S., Nuntanakorn, P., Ososki, A.L., Mori, S.A., Duke, J., Coleton, M., Kronenberg, F. Phytomedicine (2002) [Pubmed]
  3. Isopropanolic extract of black cohosh stimulates osteoprotegerin production by human osteoblasts. Viereck, V., Gründker, C., Friess, S.C., Frosch, K.H., Raddatz, D., Schoppet, M., Nisslein, T., Emons, G., Hofbauer, L.C. J. Bone Miner. Res. (2005) [Pubmed]
  4. In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes. Gurley, B.J., Gardner, S.F., Hubbard, M.A., Williams, D.K., Gentry, W.B., Khan, I.A., Shah, A. Clin. Pharmacol. Ther. (2005) [Pubmed]
  5. Estrogen bioactivity in fo-ti and other herbs used for their estrogen-like effects as determined by a recombinant cell bioassay. Oerter Klein, K., Janfaza, M., Wong, J.A., Chang, R.J. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  6. Evaluation of triterpene glycoside estrogenic activity using LC/MS and immunoaffinity extraction. Onorato, J., Henion, J.D. Anal. Chem. (2001) [Pubmed]
  7. Influence of marketed herbal menopause preparations on MCF-7 cell proliferation. Bodinet, C., Freudenstein, J. Menopause (New York, N.Y.) (2004) [Pubmed]
  8. Hot flashes--a review of the literature on alternative and complementary treatment approaches. Philp, H.A. Alternative medicine review : a journal of clinical therapeutic. (2003) [Pubmed]
  9. Antiestrogenic activities of Cimicifuga racemosa extracts. Zierau, O., Bodinet, C., Kolba, S., Wulf, M., Vollmer, G. J. Steroid Biochem. Mol. Biol. (2002) [Pubmed]
  10. Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans. Gurley, B.J., Barone, G.W., Williams, D.K., Carrier, J., Breen, P., Yates, C.R., Song, P.F., Hubbard, M.A., Tong, Y., Cheboyina, S. Drug Metab. Dispos. (2006) [Pubmed]
  11. The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers. Wuttke, W., Seidlová-Wuttke, D., Gorkow, C. Maturitas. (2003) [Pubmed]
  12. Apoptosis of human prostate androgen-dependent and -independent carcinoma cells induced by an isopropanolic extract of black cohosh involves degradation of cytokeratin (CK) 18. Hostanska, K., Nisslein, T., Freudenstein, J., Reichling, J., Saller, R. Anticancer Res. (2005) [Pubmed]
  13. Effects of fukinolic acid and cimicifugic acids from Cimicifuga species on collagenolytic activity. Kusano, A., Seyama, Y., Nagai, M., Shibano, M., Kusano, G. Biol. Pharm. Bull. (2001) [Pubmed]
  14. Effects of black cohosh (Cimicifuga racemosa) on bone turnover, vaginal mucosa, and various blood parameters in postmenopausal women: a double-blind, placebo-controlled, and conjugated estrogens-controlled study. Wuttke, W., Gorkow, C., Seidlová-Wuttke, D. Menopause (New York, N.Y.) (2006) [Pubmed]
  15. Evidence for selective estrogen receptor modulator activity in a black cohosh (Cimicifuga racemosa) extract: comparison with estradiol-17beta. Seidlova-Wuttke, D., Hesse, O., Jarry, H., Christoffel, V., Spengler, B., Becker, T., Wuttke, W. Eur. J. Endocrinol. (2003) [Pubmed]
  16. No estrogen-like effects of an isopropanolic extract of Rhizoma Cimicifugae racemosae on uterus and vena cava of rats after 17 day treatment. Kretzschmar, G., Nisslein, T., Zierau, O., Vollmer, G. J. Steroid Biochem. Mol. Biol. (2005) [Pubmed]
  17. Evaluation of cell death caused by triterpene glycosides and phenolic substances from Cimicifuga racemosa extract in human MCF-7 breast cancer cells. Hostanska, K., Nisslein, T., Freudenstein, J., Reichling, J., Saller, R. Biol. Pharm. Bull. (2004) [Pubmed]
  18. In vitro formation of quinoid metabolites of the dietary supplement Cimicifuga racemosa (black cohosh). Johnson, B.M., van Breemen, R.B. Chem. Res. Toxicol. (2003) [Pubmed]
  19. Inhibition of neutrophil elastase activity by cinnamic acid derivatives from Cimicifuga racemosa. Löser, B., Kruse, S.O., Melzig, M.F., Nahrstedt, A. Planta Med. (2000) [Pubmed]
  20. Growth inhibitory activity of extracts and purified components of black cohosh on human breast cancer cells. Einbond, L.S., Shimizu, M., Xiao, D., Nuntanakorn, P., Lim, J.T., Suzui, M., Seter, C., Pertel, T., Kennelly, E.J., Kronenberg, F., Weinstein, I.B. Breast Cancer Res. Treat. (2004) [Pubmed]
  21. Identification of caffeic acid derivatives in Actea racemosa (Cimicifuga racemosa, black cohosh) by liquid chromatography/tandem mass spectrometry. Li, W., Sun, Y., Liang, W., Fitzloff, J.F., van Breemen, R.B. Rapid Commun. Mass Spectrom. (2003) [Pubmed]
  22. Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin. Gurley, B., Hubbard, M.A., Williams, D.K., Thaden, J., Tong, Y., Gentry, W.B., Breen, P., Carrier, D.J., Cheboyina, S. Journal of clinical pharmacology. (2006) [Pubmed]
  23. Alteration of the effects of cancer therapy agents on breast cancer cells by the herbal medicine black cohosh. Rockwell, S., Liu, Y., Higgins, S.A. Breast Cancer Res. Treat. (2005) [Pubmed]
  24. Is black cohosh estrogenic? Mahady, G.B. Nutr. Rev. (2003) [Pubmed]
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