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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Human Characteristics

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High impact information on Human Characteristics

  • Progressive neurological phenotypes and pathological lesions that developed in the GAN null mice recapitulate characteristic human GAN features [1].
  • The tumor-associated binding characteristics of this antibody, its efficient internalization, and its human nature, make PH1-IgG1 a valuable candidate for further studies as a cancer-targeting immunotherapeutic [2].
  • With this system, we found that de novo expression of the fucosyltransferase in mouse recipient cells was associated with the transfer and stable genomic integration of characteristic human DNA restriction fragments [3].
  • These findings constitute direct evidence for disturbed craniofacial development in schizophrenia and indicate origins in the foetal period during which the characteristic human facial pattern evolves in close association with brain differentiation [4].
  • When somatic cell hybrid DNAs were restricted with Eco R1 and Southern blots hybridized with the human Cx50 DNA probe, the characteristic human restriction pattern was observed only when human chromosome 1 was present in the hybrid panel [5].

Chemical compound and disease context of Human Characteristics


Gene context of Human Characteristics

  • Finally, the article questions how society can maintain its discriminatory policies against homosexuality when it is no more a distinctive trait in human nature than left-handedness [9].


  1. Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport. Ding, J., Allen, E., Wang, W., Valle, A., Wu, C., Nardine, T., Cui, B., Yi, J., Taylor, A., Jeon, N.L., Chu, S., So, Y., Vogel, H., Tolwani, R., Mobley, W., Yang, Y. Hum. Mol. Genet. (2006) [Pubmed]
  2. A human immunoglobulin G1 antibody originating from an in vitro-selected Fab phage antibody binds avidly to tumor-associated MUC1 and is efficiently internalized. Henderikx, P., Coolen-van Neer, N., Jacobs, A., van der Linden, E., Arends, J.W., Müllberg, J., Hoogenboom, H.R. Am. J. Pathol. (2002) [Pubmed]
  3. A cloned human DNA restriction fragment determines expression of a GDP-L-fucose: beta-D-galactoside 2-alpha-L-fucosyltransferase in transfected cells. Evidence for isolation and transfer of the human H blood group locus. Rajan, V.P., Larsen, R.D., Ajmera, S., Ernst, L.K., Lowe, J.B. J. Biol. Chem. (1989) [Pubmed]
  4. The anthropometric assessment of dysmorphic features in schizophrenia as an index of its developmental origins. Lane, A., Kinsella, A., Murphy, P., Byrne, M., Keenan, J., Colgan, K., Cassidy, B., Sheppard, N., Horgan, R., Waddington, J.L., Larkin, C., O'Callaghan, E. Psychological medicine. (1997) [Pubmed]
  5. The human lens intrinsic membrane protein MP70 (Cx50) gene: clonal analysis and chromosome mapping. Church, R.L., Wang, J.H., Steele, E. Curr. Eye Res. (1995) [Pubmed]
  6. Role of retinal metabolism in methanol-induced retinal toxicity. Garner, C.D., Lee, E.W., Terzo, T.S., Louis-Ferdinand, R.T. Journal of toxicology and environmental health. (1995) [Pubmed]
  7. Bully/victim problems and their association with Machiavellianism and self-efficacy in Greek primary school children. Andreou, E. The British journal of educational psychology. (2004) [Pubmed]
  8. T cell subsets and their lymphokines. De Berardinis, P. Ann. Ist. Super. Sanita (1991) [Pubmed]
  9. Dexterity and sexuality: is there a relationship? Hamill, J.A. Journal of homosexuality. (1995) [Pubmed]
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