Disease relevance of Bacopa

• Nitric oxide-related toxicity in cultured astrocytes: effect of Bacopa monniera [1].
• Among 169 patients with irritable bowel syndrome (IBS), standard therapy (with clidinium bromide, chlordiazepoxide and isaphaghulla), a compound Ayurvedic preparation (with Aegle marmelos correa plus Bacopa monniere Linn) along with a matching placebo were given in a double blind randomised trial for 6 wk [2].

High impact information on Bacopa

• Therefore the present study was designed to investigate the influence of chronic cigarette smoke exposure on apoptosis and the modulatory effect of bacoside A (triterpenoid saponin isolated from the plant Bacopa monniera) on smoking-induced apoptosis in rat brain [3].
• Dammarane triterpene saponin from Bacopa monniera as the superoxide inhibitor in polymorphonuclear cells [4].
• Bacopa monnieri L. plants exposed to 10, 50, 100 and 200 microM cadmium (Cd) for 48, 96 and 144 h were analysed with reference to the accumulation of metal and its influence on various enzymatic and non-enzymatic antioxidants, thiobarbituric acid reactive substances (TBARS), photosynthetic pigments and protein content [5].
• The effect of Fe was investigated in medicinally important plant, Bacopa monnieri L. and the response on malondialdehyde (MDA) content, superoxide dismutase (SOD), peroxidase (POD) and ascorbate peroxidase (APX) was found different in roots and leaves of the metal treated plants [6].
• A new sterol glycoside, bacosterol-3-O-beta-D-glucopyranoside along with bacopasaponin-C, bacopaside-I, bacopaside-II, bacosterol, bacosine and luteolin-7-O-beta-glucopyranoside have been isolated from Bacopa monnieri [7].

Chemical compound and disease context of Bacopa

• Responses of Bacopa monniera cultures to cadmium toxicity [8].

Biological context of Bacopa

• Cadmium accumulation and its influence on lipid peroxidation and antioxidative system in an aquatic plant, Bacopa monnieri L [5].
• The effects of the crude ethanolic extract of whole plant of Bacopa monnieri have been evaluated on left ventricular contractility, heart rate and coronary flow in isolated rabbit hearth showed cardiac depressive activity in all parameters, like quinidine [9].

Associations of Bacopa with chemical compounds

• The present study demonstrates the calcium antagonistic activity in ethanol extract of Bacopa monniera [10].
• Protection from phenytoin-induced cognitive deficit by Bacopa monniera, a reputed Indian nootropic plant [11].
• This review covers five such therapies: phosphatidylserine (PS), acetyl-l-carnitine (ALC), vinpocetine, Ginkgo biloba extract (GbE), and Bacopa monniera (Bacopa) [12].

Gene context of Bacopa

• Bacopa monniera (BM) induced a dose-related increase in SOD, CAT and GPX activities, in all the brain regions investigated, after 14 and 21 days of drug administration [13].
• Antistress effects of bacosides of Bacopa monnieri: modulation of Hsp70 expression, superoxide dismutase and cytochrome P450 activity in rat brain [14].
• Bacopa monniera Linn. as an antioxidant: mechanism of action [15].
• Micropropagation of Bacopa monnieri was achieved on MS and B5 medium supplemented with BAP and NAA using leaf explants and nodal segments [16].

References