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MeSH Review

Fritillaria

 
 
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Disease relevance of Fritillaria

 

High impact information on Fritillaria

  • (type strain VKM Ac-2059T = IFO 16404T) is proposed for aerobic, oxidase- and catalase-positive, coryneform bacteria isolated from seeds of Fritillaria ruthenica Wikstr. and Clematis recta L [2].
  • The simultaneous separation of eight Fritillaria alkaloids was achieved on a reversed-phase C8 column with an isocratic mobile phase system consisting of acetonitrile-methanol-water (66.5:3.5:30, v/v) containing 0.006% triethylamine [3].
  • Derivatization was carried out by trimethylsilylation of the hydroxyl-containing Fritillaria alkaloids to the corresponding trimethylsilylates with trimethylsilylimidazole [4].
  • Puqienine F, a Novel Veratramine Alkaloid from the Bulbs of Fritillaria puqiensis [5].
  • Four new steroidal alkaloids, puqienine A (1), puqienine B (2), N-demethylpuqietinone (3), and puqietinonoside (4), along with a known steroidal alkaloid, puqietinone, were isolated from the bulbs of Fritillaria puqiensis [6].
 

Associations of Fritillaria with chemical compounds

  • Interaction of ebeinone, an alkaloid from Fritillaria imperialis, at two muscarinic acetylcholine receptor subtypes [7].
  • Our results showed that the hexane, butanol, and water extracts of Bulbus Fritillaria increased NO and cGMP productions in intact vascular tissue [8].
  • A novel diterpenoid ester, fritillahupehin (1) and three known fatty acids, palmitic acid (2), lignoceric acid (3) and azelaric acid (4), have been isolated from the bulbs of Fritillaria hupehensis Hsiao et K.C. Hsia [9].
  • Effects of bulb of Fritillaria ussuriensis maxim. on angiotensin converting enzyme and vascular release of NO/cGMP in rats [8].
  • The ACE activities were inhibited significantly by the additions of ethylacetate and butanol extracts from Bulbus Fritillaria, of which IC(50) values were 292 and 320 microg/ml, respectively [8].
 

Gene context of Fritillaria

  • A glucosylsterol, beta-sitosterol-3-O-glucopyranoside, has been isolated as an active principle with sortase inhibitory effect from the bulbs of Fritillaria verticillata by bioassay-guided chromatographic fractionation [10].

References

  1. Effects of bulbus Fritillaria water extract on blood pressure and renal functions in the L-NAME-induced hypertensive rats. Kang, D.G., Sohn, E.J., Lee, Y.M., Lee, A.S., Han, J.H., Kim, T.Y., Lee, H.S. Journal of ethnopharmacology. (2004) [Pubmed]
  2. Okibacterium fritillariae gen. nov., sp. nov., a novel genus of the family Microbacteriaceae. Evtushenko, L.I., Dorofeeva, L.V., Krausova, V.I., Gavrish, E.Y., Yashina, S.G., Takeuchi, M. Int. J. Syst. Evol. Microbiol. (2002) [Pubmed]
  3. Determination of the major isosteroidal alkaloids in bulbs of Fritillaria by high-performance liquid chromatography coupled with evaporative light scattering detection. Li, S.L., Lin, G., Chan, S.W., Li, P. Journal of chromatography. A. (2001) [Pubmed]
  4. Pre-column derivatization and gas chromatographic determination of alkaloids in bulbs of Fritillaria. Li, S.L., Chan, S.W., Li, P., Lin, G., Zhou, G.H., Ren, Y.J., Chiu, F.C. Journal of chromatography. A. (1999) [Pubmed]
  5. Puqienine F, a Novel Veratramine Alkaloid from the Bulbs of Fritillaria puqiensis. Li, H.J., Jiang, Y., Li, P., Ye, W.C. Chem. Pharm. Bull. (2006) [Pubmed]
  6. Steroidal alkaloids from the bulbs of Fritillaria puqiensis. Jiang, Y., Li, H., Li, P., Cai, Z., Ye, W. J. Nat. Prod. (2005) [Pubmed]
  7. Interaction of ebeinone, an alkaloid from Fritillaria imperialis, at two muscarinic acetylcholine receptor subtypes. Gilani, A.H., Shaheen, F., Christopoulos, A., Mitchelson, F. Life Sci. (1997) [Pubmed]
  8. Effects of bulb of Fritillaria ussuriensis maxim. on angiotensin converting enzyme and vascular release of NO/cGMP in rats. Kang, D.G., Oh, H., Cho, D.K., Kwon, E.K., Han, J.H., Lee, H.S. Journal of ethnopharmacology. (2002) [Pubmed]
  9. Structural elucidation of fritillahupehin from bulbs of Fritillaria hupehensis Hsiao et K.C. Hsia. Zhang, Y.H., Ruan, H.L., Pi, H.F., Wu, J.Z., Sun, H.D., Fujita, T. Journal of Asian natural products research. (2004) [Pubmed]
  10. Inhibition of sortase, a bacterial surface protein anchoring transpeptidase, by beta-sitosterol-3-O-glucopyranoside from Fritillaria verticillata. Kim, S.H., Shin, D.S., Oh, M.N., Chung, S.C., Lee, J.S., Chang, I.M., Oh, K.B. Biosci. Biotechnol. Biochem. (2003) [Pubmed]
 
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