Disease relevance of Vaginal Neoplasms

• Tamoxifen induces endometrial and vaginal cancer in rats in the absence of endometrial hyperplasia [1].
• A clear cell adenocarcinoma of the vaginal remnant in a diethylstilbestrol (DES)-exposed woman developed 20 years after anterior exenteration for a histologically similar stage II vaginal cancer [2].
• The role of estrogen use during pregnancy in the causation of vaginal cancer in female offspring and the role of androgens in prostate cancer have been discussed [3].

High impact information on Vaginal Neoplasms

• The existing evidence of a DES/vaginal cancer relation is currently too weak for the causal role of DES to be regarded as established [4].
• Protein patterns in six samples from primary vaginal cancers, in five from normal vaginal tissue and in five primary cervical cancers, were analysed using two-dimensional polyacrylamide gel electrophoresis (2-DE) [5].
• In view of the risk of vaginal cancer developing in young female subjects exposed in utero to maternally ingested diethylstilbestrol a pilot study was undertaken of male subjects similarly exposed [6].
• Serum squamous cell carcinoma antigen levels in patients with invasive squamous vulvar and vaginal cancer: a preliminary report [7].
• Phase II trial of cisplatin in advanced or recurrent cancer of the vagina: a Gynecologic Oncology Group Study [8].

Chemical compound and disease context of Vaginal Neoplasms

• This patient is unique in that development of the vaginal neoplasm occurred in the absence of estrogen influence [9].
• Cervical and vaginal cancer detection at a regional diethylstilbestrol (DES) screening clinic [10].
• CO2 laser for the treatment of invasive vulvar and vaginal cancer [11].
• Bauer has proposed that H2O2-producing lactobacilli also might exert control over vaginal cancer through specific interactions of reactive oxygen species, such as superoxide anion, hydroxyl radicals, and hypochlorous acid [12].
• On account of the relatively benign nature of VAIN than that of invasive vaginal cancer and the need for preservation of a functional vagina, more conservative approaches, for example, topical 5-Fluorouracil application and carbon dioxide laser vaporization, are discussed [13].

Biological context of Vaginal Neoplasms

• A few clues are available regarding the epidemiology of fallopian tube cancers and vaginal cancers other than those produced by maternal stilbestrol [14].

Gene context of Vaginal Neoplasms

• The National Cancer Data Base report on cancer of the vagina [15].
• Next, we determined serum IL-5 levels prospectively in 20 patients, comprising 18 cases of cervical cancer, one of uterine corpus cancer, and one of vaginal cancer [16].

Analytical, diagnostic and therapeutic context of Vaginal Neoplasms

• Twenty-six patients with advanced or recurrent cancer of the vagina no longer amenable to control with surgery and/or radiotherapy were entered into a phase II study of cisplatin 50 mg/m2 intravenously every 3 weeks [8].
• Stage II vaginal cancer responding to chemotherapy with irinotecan and cisplatin: a case report [17].
• Data from two case-control studies that showed an association between in utero diethylstilbestrol (DES) exposure and clear cell vaginal cancer are evaluated [18].

References