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Disease relevance of Mannheimia


High impact information on Mannheimia


Chemical compound and disease context of Mannheimia

  • OBJECTIVE: To evaluate an experimental model of the pharmacokinetic/pharmacodynamic (PK/PD) relationship of danofloxacin against Mannheimia haemolytica infection, using subcutaneously implanted tissue cages in calves [11].
  • Tetracycline resistance in P. multocida and Mannheimia spp. is mediated by at least three different tet genes [12].
  • Based on the polyphasic investigation performed a new genus Mannheimia is proposed for the trehalose-negative [P.] haemolytica complex [13].
  • Mannheimia glucosida sp. nov. corresponds to [P.] haemolytica biogroups 3A-3H and the beta-glucosidase and meso-inositol-positive strains of [P.] haemolytica biogroup 9 [13].
  • Here, a 449- to 473-bp fragment (sodA(int)) internal to the sodA gene, encoding the manganese-dependent superoxide dismutase, was amplified and sequenced with a single pair of degenerate primers from the type strains of Pasteurella (18 strains), Gallibacterium (1 strain), and Mannheimia (5 strains) species [14].

Biological context of Mannheimia


Anatomical context of Mannheimia


Gene context of Mannheimia

  • We performed immunohistochemistry and immuno-gold electron microscopy to localize TLR4 in lung and seven other organs from normal pig, dog and calf (n=2 each) and in inflamed lungs from calves (n=4) challenged with Mannheimia hemolytica [23].
  • Previously, we and others showed that CD18 of LFA-1 serves as a receptor for Mannheimia haemolytica leukotoxin (Lkt) [24].
  • Since a hallmark of bronchopneumonia is the initiation of inflammation in the bronchi and bronchoalveolar junction, we chose a classic ruminant model of bronchopneumonia caused by Mannheimia haemolytica to study the expression of SP-D within the bronchioles of infected lambs [25].
  • We measured plasma levels of LBP in a group of 20 calves experimentally infected with Gram-negative Mannheimia haemolytica (Pasteurella) in comparison to haptoglobin, the most widely studied APP in cattle [26].
  • Three vesicle proteins were identified; the heat-modifiable OmpA homologue of A. actinomycetemcomitans, a 28 kDa lipoprotein related to the major outer membrane lipoprotein of Mannheimia haemolytica and leukotoxin [27].

Analytical, diagnostic and therapeutic context of Mannheimia


  1. Bovine CD18 is necessary and sufficient to mediate Mannheimia (Pasteurella) haemolytica leukotoxin-induced cytolysis. Deshpande, M.S., Ambagala, T.C., Ambagala, A.P., Kehrli, M.E., Srikumaran, S. Infect. Immun. (2002) [Pubmed]
  2. Construction of in-frame aroA deletion mutants of Mannheimia haemolytica, Pasteurella multocida, and Haemophilus somnus by using a new temperature-sensitive plasmid. Tatum, F.M., Briggs, R.E. Appl. Environ. Microbiol. (2005) [Pubmed]
  3. Depletion of pulmonary intravascular macrophages inhibits acute lung inflammation. Singh, B., Pearce, J.W., Gamage, L.N., Janardhan, K., Caldwell, S. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  4. Distribution of substance P receptor (neurokinin-1 receptor) in normal ovine lung and during the progression of bronchopneumonia in sheep. Grubor, B., Ramirez-Romero, R., Gallup, J.M., Bailey, T.B., Ackermann, M.R. J. Histochem. Cytochem. (2004) [Pubmed]
  5. Bacterial ghosts as novel advanced drug delivery systems: antiproliferative activity of loaded doxorubicin in human Caco-2 cells. Paukner, S., Kohl, G., Lubitz, W. Journal of controlled release : official journal of the Controlled Release Society. (2004) [Pubmed]
  6. Mapping of the binding site for Mannheimia haemolytica leukotoxin within bovine CD18. Dileepan, T., Kannan, M.S., Walcheck, B., Thumbikat, P., Maheswaran, S.K. Infect. Immun. (2005) [Pubmed]
  7. Coordinated expression of tracheal antimicrobial peptide and inflammatory-response elements in the lungs of neonatal calves with acute bacterial pneumonia. Caverly, J.M., Diamond, G., Gallup, J.M., Brogden, K.A., Dixon, R.A., Ackermann, M.R. Infect. Immun. (2003) [Pubmed]
  8. Construction and characterization of an acapsular mutant of Mannheimia haemolytica A1. McKerral, L.J., Lo, R.Y. Infect. Immun. (2002) [Pubmed]
  9. Genome-based metabolic engineering of Mannheimia succiniciproducens for succinic acid production. Lee, S.J., Song, H., Lee, S.Y. Appl. Environ. Microbiol. (2006) [Pubmed]
  10. tet(L)-mediated tetracycline resistance in bovine Mannheimia and Pasteurella isolates. Kehrenberg, C., Catry, B., Haesebrouck, F., de Kruif, A., Schwarz, S. J. Antimicrob. Chemother. (2005) [Pubmed]
  11. Pharmacokinetic/pharmacodynamic relationship of danofloxacin against Mannheimia haemolytica in a tissue-cage model in calves. Greko, C., Finn, M., Franklin, A., Bengtsson, B. J. Antimicrob. Chemother. (2003) [Pubmed]
  12. Tetracycline resistance genes in isolates of Pasteurella multocida, Mannheimia haemolytica, Mannheimia glucosida and Mannheimia varigena from bovine and swine respiratory disease: intergeneric spread of the tet(H) plasmid pMHT1. Kehrenberg, C., Salmon, S.A., Watts, J.L., Schwarz, S. J. Antimicrob. Chemother. (2001) [Pubmed]
  13. Taxonomic relationships of the [Pasteurella] haemolytica complex as evaluated by DNA-DNA hybridizations and 16S rRNA sequencing with proposal of Mannheimia haemolytica gen. nov., comb. nov., Mannheimia granulomatis comb. nov., Mannheimia glucosida sp. nov., Mannheimia ruminalis sp. nov. and Mannheimia varigena sp. nov. Angen, O., Mutters, R., Caugant, D.A., Olsen, J.E., Bisgaard, M. Int. J. Syst. Bacteriol. (1999) [Pubmed]
  14. Rapid and accurate identification of human isolates of Pasteurella and related species by sequencing the sodA gene. Gautier, A.L., Dubois, D., Escande, F., Avril, J.L., Trieu-Cuot, P., Gaillot, O. J. Clin. Microbiol. (2005) [Pubmed]
  15. Lipopolysaccharide enhances cytolysis and inflammatory cytokine induction in bovine alveolar macrophages exposed to Pasteurella (Mannheimia) haemolytica leukotoxin. Lafleur, R.L., Malazdrewich, C., Jeyaseelan, S., Bleifield, E., Abrahamsen, M.S., Maheswaran, S.K. Microb. Pathog. (2001) [Pubmed]
  16. Comparison of pharmacokinetics of danofloxacin and enrofloxacin in calves challenged with Mannheimia haemolytica. TerHune, T.N., Skogerboe, T.L., Shostrom, V.K., Weigel, D.J. Am. J. Vet. Res. (2005) [Pubmed]
  17. Effect of danofloxacin and tilmicosin on body temperatures of beef calves with pneumonia experimentally induced by inoculation with Mannheimia haemolytica. Fajt, V.R., Apley, M.D., Brogden, K.A., Skogerboe, T.L., Shostrom, V.K., Chin, Y.L. Am. J. Vet. Res. (2004) [Pubmed]
  18. Effects of Mannheimia haemolytica leukotoxin on apoptosis and oncosis of bovine neutrophils. Cudd, L.A., Ownby, C.L., Clarke, C.R., Sun, Y., Clinkenbeard, K.D. Am. J. Vet. Res. (2001) [Pubmed]
  19. Pharmacological inhibition of Mannheimia haemolytica lipopolysaccharide and leukotoxin-induced cytokine expression in bovine alveolar macrophages. Malazdrewich, C., Thumbikat, P., Abrahamsen, M.S., Maheswaran, S.K. Microb. Pathog. (2004) [Pubmed]
  20. Pasteurella (Mannheimia) haemolytica leukotoxin-induced cytolysis of bovine leukocytes: role of arachidonic acid and its regulation. Jeyaseelan, S., Kannan, M.S., Hsuan, S.L., Singh, A.K., Walseth, T.F., Maheswaran, S.K. Microb. Pathog. (2001) [Pubmed]
  21. A selectin inhibitor decreases neutrophil infiltration during acute Mannheimia haemolytica pneumonia. Radi, Z.A., Brogden, K.A., Dixon, R.A., Gallup, J.M., Ackermann, M.R. Vet. Pathol. (2002) [Pubmed]
  22. Pharmacokinetics and pharmacodynamics of danofloxacin in serum and tissue fluids of goats following intravenous and intramuscular administration. Aliabadi, F.S., Lees, P. Am. J. Vet. Res. (2001) [Pubmed]
  23. Toll-like receptor 4 in normal and inflamed lungs and other organs of pig, dog and cattle. Wassef, A., Janardhan, K., Pearce, J.W., Singh, B. Histol. Histopathol. (2004) [Pubmed]
  24. Molecular cloning and characterization of cDNA encoding CD11b of cattle. Gopinath, R.S., Ambagala, A.P., Ambagala, T.C., Liu, W., Srikumaran, S. Vet. Immunol. Immunopathol. (2006) [Pubmed]
  25. Surfactant protein D expression in normal and pneumonic ovine lung. Grubor, B., Gallup, J.M., Ramírez-Romero, R., Bailey, T.B., Crouch, E.C., Brogden, K.A., Ackermann, M.R. Vet. Immunol. Immunopathol. (2004) [Pubmed]
  26. A novel acute phase marker in cattle: lipopolysaccharide binding protein (LBP). Schroedl, W., Fuerll, B., Reinhold, P., Krueger, M., Schuett, C. J. Endotoxin Res. (2001) [Pubmed]
  27. Outer membrane-like vesicles secreted by Actinobacillus actinomycetemcomitans are enriched in leukotoxin. Kato, S., Kowashi, Y., Demuth, D.R. Microb. Pathog. (2002) [Pubmed]
  28. Comparison of bronchoalveolar lavage fluid obtained from Mannheimia haemolytica-inoculated calves with and without prior treatment with the selectin inhibitor TBC1269. Caverly, J.M., Radi, Z.A., Andreasen, C.B., Dixon, R.A., Brogden, K.A., Ackermann, M.R. Am. J. Vet. Res. (2001) [Pubmed]
  29. Conglutinin and immunoconglutinin titers in stressed calves in a feedlot. Purdy, C.W., Loan, R.W., Straus, D.C., Briggs, R.E., Frank, G.H. Am. J. Vet. Res. (2000) [Pubmed]
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