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MeSH Review:

GB virus A

Charrel, R.N. et al., Karayiannis, P. et al., Bukh, J. et al., Simons, J.N. et al.

Simons, Desai, Schultz, Lemon, Mushahwar,

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Disease relevance of GB virus A

Translation studies were undertaken to determine the mechanism and sites of polyprotein initiation in GBV-A and GBV-C [1].
No patient sera from groups exposed to blood and blood products were found to be positive when tested for the presence of GBV-A or GBV-B sequences, two other recently described flaviviruses [2].

High impact information on GB virus A

In addition, the genomic region corresponding to the putative NS3 RNA helicase of GBV-A was amplified from most positive animals and sequenced [3].

Biological context of GB virus A

It has now been determined that analysis of subgenomic amino acid sequences in the E2 and NS5 regions of GBV-A and a 345 nucleotide segment in the 5' non-coding (5'NC) region was able to reproduce the phylogenetic relationships obtained by complete polyprotein sequences analysis [4].

References

Translation initiation in GB viruses A and C: evidence for internal ribosome entry and implications for genome organization. Simons, J.N., Desai, S.M., Schultz, D.E., Lemon, S.M., Mushahwar, I.K. J. Virol. (1996) [Pubmed]
Hepatitis G virus infection: clinical characteristics and response to interferon. Karayiannis, P., Hadziyannis, S.J., Kim, J., Pickering, J.M., Piatak, M., Hess, G., Yun, A., McGarvey, M.J., Wages, J., Thomas, H.C. J. Viral Hepat. (1997) [Pubmed]
Five new or recently discovered (GBV-A) virus species are indigenous to New World monkeys and may constitute a separate genus of the Flaviviridae. Bukh, J., Apgar, C.L. Virology (1997) [Pubmed]
Phylogenetic analysis of GB viruses A and C: evidence for cospeciation between virus isolates and their primate hosts. Charrel, R.N., De Micco, P., de Lamballerie, X. J. Gen. Virol. (1999) [Pubmed]

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