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Disease relevance of Corydalis

  • Eighteen isoquinoline alkaloids including protoberberines (1-12), benzophenanthridines (13-16) and an aporphine (17) isolated from plants of Corydalis species (Fumariaceae) were tested for inhibitory effects on Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol 13-acetate in Raji cells [1].
  • Trypsin inhibitors from Phaseolus lunatus and Glycine max, gossypol and alkaloids from Corydalis yanhusuo were able to inhibit HIV-1 reverse transcriptase [2].

High impact information on Corydalis


Biological context of Corydalis


Anatomical context of Corydalis


Associations of Corydalis with chemical compounds

  • Anti-thrombic action of methanol extract and alkaloidal components from Corydalis tuber [12].
  • Our results suggest that prolonged exposure to Corydalis ternata may be one of the ways to regulate glutamate concentration in brain through the activation of GDH [13].
  • A novel substance, isocoryne, affecting the GABA receptor complex, was isolated from the Corydalis pseudoadunca plant [14].
  • Flavonoid glycosides and isoquinolinone alkaloids from Corydalis bungeana [15].
  • Two flavonol O-glycosides identified as the 3-O-alpha-arabinopyranosyl(1'''-->6'')-beta-glucopyranoside 7-O-beta-glucopyranosides of kaempferol and quercetin were isolated from the whole plant of Corydalis bungeana Turcz. together with eight known flavonol O-glycosides [15].

Gene context of Corydalis


Analytical, diagnostic and therapeutic context of Corydalis


  1. Chemopreventive activity of isoquinoline alkaloids from Corydalis plants. Ito, C., Itoigawa, M., Tokuda, H., Kuchide, M., Nishino, H., Furukawa, H. Planta Med. (2001) [Pubmed]
  2. Examination of lectins, polysaccharopeptide, polysaccharide, alkaloid, coumarin and trypsin inhibitors for inhibitory activity against human immunodeficiency virus reverse transcriptase and glycohydrolases. Wang, H.X., Ng, T.B. Planta Med. (2001) [Pubmed]
  3. Molecular cloning and characterization of 12-oxophytodienoate reductase, an enzyme of the octadecanoid signaling pathway from Arabidopsis thaliana. Structural and functional relationship to yeast old yellow enzyme. Schaller, F., Weiler, E.W. J. Biol. Chem. (1997) [Pubmed]
  4. Molecular cloning and analysis of a cDNA coding for chorismate synthase from the higher plant Corydalis sempervirens Pers. Schaller, A., Schmid, J., Leibinger, U., Amrhein, N. J. Biol. Chem. (1991) [Pubmed]
  5. Determination of tetrahydropalmatine in Chinese traditional medicine by nonaqueous capillary electrophoresis. Ji, S.G., Chai, Y.F., Zhang, G.Q., Wu, Y.T., Yin, X.P., Liang, D.S., Xu, Z.M. Electrophoresis (1999) [Pubmed]
  6. Glyphosate tolerance of cultured Corydalis sempervirens cells is acquired by an increased rate of transcription of 5-enolpyruvylshikimate 3-phosphate synthase as well as by a reduced turnover of the enzyme. Holländer-Czytko, H., Sommer, I., Amrhein, N. Plant Mol. Biol. (1992) [Pubmed]
  7. (+)-Hydrastine, a potent competitive antagonist at mammalian GABAA receptors. Huang, J.H., Johnston, G.A. Br. J. Pharmacol. (1990) [Pubmed]
  8. Positive cooperation of protoberberine type 2 alkaloids from Corydalis cava on the GABA(A) binding site. Halbsguth, C., Meissner, O., Häberlein, H. Planta Med. (2003) [Pubmed]
  9. Acetylcholinesterase inhibitors from the aerial parts of Corydalis speciosa. Kim, D.K., Lee, K.T., Baek, N.I., Kim, S.H., Park, H.W., Lim, J.P., Shin, T.Y., Eom, D.O., Yang, J.H., Eun, J.S. Arch. Pharm. Res. (2004) [Pubmed]
  10. Modulation of Corydalis tuber on glycine-induced ion current in acutely dissociated rat periaqueductal gray neurons. Cheong, B.S., Choi, D.Y., Cho, N.H., Lee, J.D., Chang, H.K., Shin, M.C., Shin, M.S., Kim, C.J. Biol. Pharm. Bull. (2004) [Pubmed]
  11. Bioconversion studies in cultured cells of Corydalis species. Iwasa, K., Kuribayashi, A., Sugiura, M., Nishiyama, Y., Ichimaru, M., Moriyasu, M., Lee, D.U. Die Pharmazie. (2004) [Pubmed]
  12. Anti-thrombic action of methanol extract and alkaloidal components from Corydalis tuber. Matsuda, H., Shiomoto, H., Naruto, S., Namba, K., Kubo, M. Planta Med. (1988) [Pubmed]
  13. Regulation of glutamate level in rat brain through activation of glutamate dehydrogenase by Corydalis ternata. Lee, K.H., Huh, J.W., Choi, M.M., Yoon, S.Y., Yang, S.J., Hong, H.N., Cho, S.W. Exp. Mol. Med. (2005) [Pubmed]
  14. Inhibitions of the GABA-induced currents of rat neurons by the alkaloid isocoryne from the plant Corydalis pseudoadunca. Chernevskaja, N.I., Krishtal, O.A., Valeyev, A.Y. Toxicon (1990) [Pubmed]
  15. Flavonoid glycosides and isoquinolinone alkaloids from Corydalis bungeana. Xie, C., Veitch, N.C., Houghton, P.J., Simmonds, M.S. Phytochemistry (2004) [Pubmed]
  16. Acetylcholinesterase and butyrylcholinesterase inhibitory activity of some Turkish medicinal plants. Orhan, I., Sener, B., Choudhary, M.I., Khalid, A. Journal of ethnopharmacology. (2004) [Pubmed]
  17. Isolation and chemistry of alkaloids from plants of the family Papaveraceae LXVII: Corydalis cava (L.) Sch. et K. (C. tuberosa DC). Preininger, V., Thakur, R.S., Santavý, F. Journal of pharmaceutical sciences. (1976) [Pubmed]
  18. Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase. Kim, D.K. Arch. Pharm. Res. (2002) [Pubmed]
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