Disease relevance of Corydalis

• Eighteen isoquinoline alkaloids including protoberberines (1-12), benzophenanthridines (13-16) and an aporphine (17) isolated from plants of Corydalis species (Fumariaceae) were tested for inhibitory effects on Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol 13-acetate in Raji cells [1].
• Trypsin inhibitors from Phaseolus lunatus and Glycine max, gossypol and alkaloids from Corydalis yanhusuo were able to inhibit HIV-1 reverse transcriptase [2].

High impact information on Corydalis

• Using partial amino acid sequence information for 12-oxophytodienoate-10,11-reductase obtained from Corydalis sempervirens we have cloned the homologous enzyme from Arabidopsis thaliana [3].
• Molecular cloning and analysis of a cDNA coding for chorismate synthase from the higher plant Corydalis sempervirens Pers [4].
• Tetrahydropalmatine in Rhizoma corydalis and its preparations were separated and determined with no pretreatment in the buffer solution of 50 mmol/L of sodium acetate in methanol containing 2 mol/L acetic acid [5].
• Glyphosate tolerance of cultured Corydalis sempervirens cells is acquired by an increased rate of transcription of 5-enolpyruvylshikimate 3-phosphate synthase as well as by a reduced turnover of the enzyme [6].
• 1. (+)-Hydrastine is a phthalide isoquinoline alkaloid, isolated from Corydalis stricta [7].

Biological context of Corydalis

• Cell cultures of Corydalis sempervirens, tolerant to the herbicide glyphosate, have a 30-40-fold increased level of the herbicide's target enzyme 5-enolpyruvylshikimate 3-phosphate (EPSP) synthase, a ten-fold enhanced level of the corresponding mRNA but no amplification of the gene (Holländer-Czytko et al., Plant Mol Biol 11 (1988) 215-220) [6].
• Positive cooperation of protoberberine type 2 alkaloids from Corydalis cava on the GABA(A) binding site [8].
• In a bioassay-guided search for acetylcholinesterase inhibitors from Korean natural resources, four isoquinoline alkaloids, corynoxidine (1), protopine (2), palmatine (3), and berberine (4) have been isolated from the methanolic extract of the aerial parts of Corydalis speciosa [9].

Anatomical context of Corydalis

• Modulation of Corydalis tuber on glycine-induced ion current in acutely dissociated rat periaqueductal gray neurons [10].
• Structural analysis of the metabolites of dopamine and salsolinol in cultured cells of Corydalis species was carried out using the combination of LC-MS and LC-NMR techniques [11].

Associations of Corydalis with chemical compounds

• Anti-thrombic action of methanol extract and alkaloidal components from Corydalis tuber [12].
• Our results suggest that prolonged exposure to Corydalis ternata may be one of the ways to regulate glutamate concentration in brain through the activation of GDH [13].
• A novel substance, isocoryne, affecting the GABA receptor complex, was isolated from the Corydalis pseudoadunca plant [14].
• Flavonoid glycosides and isoquinolinone alkaloids from Corydalis bungeana [15].
• Two flavonol O-glycosides identified as the 3-O-alpha-arabinopyranosyl(1'''-->6'')-beta-glucopyranoside 7-O-beta-glucopyranosides of kaempferol and quercetin were isolated from the whole plant of Corydalis bungeana Turcz. together with eight known flavonol O-glycosides [15].

Gene context of Corydalis

• Regulation of glutamate level in rat brain through activation of glutamate dehydrogenase by Corydalis ternata [13].
• When treated with protopine and alkalized extracts of the tuber of Corydalis ternata for one year, significant decrease in glutamate level and increase in glutamate dehydrogenase (GDH) activity was observed in rat brains [13].
• Among them, Rhododendron ponticum subsp. ponticum, Corydalis solida subsp. solida and Buxus sempervirens were the most active extracts against BChE having 95.46 +/- 1.03%, 93.08 +/- 0.97%, and 93.45 +/- 0.88% inhibition rates, respectively [16].
• From Corydalis cava (L.) Sch. et K [17].
• Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase [18].

Analytical, diagnostic and therapeutic context of Corydalis

• In the present study, modulation of the Corydalis tuber on glycine-activated ion current in the acutely dissociated periaqueductal gray (PAG) neurons was studied by a nystatin-perforated patch-clamp technique [10].

References