Disease relevance of Endometrial Stromal Tumors

• As a result, a panel of CD10, h-caldesmon, and desmin should be used and will distinguish endometrial stromal tumors from highly cellular leiomyomas in most cases [1].
• 7) c-kit may help distinguish metastatic endometrial stromal tumors of the uterus (c-kit negative) from gastrointestinal stromal tumors (c-kit positive) [1].

High impact information on Endometrial Stromal Tumors

• Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors [2].
• Endometrial stromal tumors with sex cord-like elements were less frequently positive for markers of sex cord differentiation, with each case positive for one marker (calretinin, two cases; CD99, one case) [3].
• The frequent expression of CD10 negates its use in the differential diagnosis with endometrial stromal tumors, and the CD10 and CD34 expression suggests that mixed tumors may arise from a primitive pluripotential cell [4].
• The major conclusions of this study are as follows: 1) Pure endometrial stromal tumors are usually desmin negative [1].
• CD10 was positive in nine of 10 endometrial stromal tumors and five of seven UTROSCTs, although very focally in the latter group [1].

Chemical compound and disease context of Endometrial Stromal Tumors

• A plan of therapy is suggested for patients with endolymphatic stromal myosis, including a rationale for adjuvant progestin therapy [5].
• Estrogen and progesterone receptor studies are recommended in all cases of endolymphatic stromal myosis [6].
• Endolymphatic stromal myosis associated with tamoxifen use [7].
• Steroid receptors in endolymphatic stromal myosis [6].
• Endolymphatic stromal myosis: a case with positive estrogen and progesterone receptors and good response to progestins [8].

Biological context of Endometrial Stromal Tumors

• None of the patients with stromal nodules or endolymphatic stromal myosis had extrauterine disease at presentation or tumors displaying a mitotic rate greater than 10/10 hpf (high-power fields), nuclear pleomorphism, atypical mitotic figures, DNA aneuploidy, or a high proliferative index (greater than 10% S phase cells) [9].

Gene context of Endometrial Stromal Tumors

• Histologic and immunohistochemical analysis of nine endometrial stromal tumors: an unexpected high frequency of keratin protein positivity [10].
• The mitotic count may not be the most useful criterion for predicting biologic behavior in endometrial stromal tumors since it does not always reflect an increased rate of cell turnover as demonstrated by the percentage of cells in the S phase [9].
• The surgical management for recurrent endolymphatic stromal myosis metastatic to the inferior vena cava is described [5].
• In 1977, a case report was published describing a 28-year-old women with an endometrial stromal tumor that showed foci of myogenic differentiation [11].
• CONCLUSION: The presence of hematopoietic or heterologous elements within an otherwise bland uterine leiomyoma or endometrial stromal tumor may give rise to diagnostic difficulties [12].

References