Disease relevance of Colitis, Microscopic

• The cause of microscopic colitis is unknown, but recent work suggests some immunologic similarities to celiac disease, suggesting that luminal antigens may be important in its pathogenesis [1].
• The reported case represents an unusual association between medication with the proton pump inhibitor lansoprazole and the development of collagenous colitis suggesting the importance of evaluation of drug use in patients with microscopic colitis [2].

High impact information on Colitis, Microscopic

• Treatment of refractory microscopic colitis with azathioprine and 6-mercaptopurine [3].
• BACKGROUND & AIMS: The pathogenesis of the microscopic colitis syndrome is unknown but may involve bacteria, an intestinal luminal antigen, and/or autoimmunity [4].
• Efficacy of open-label bismuth subsalicylate for the treatment of microscopic colitis [4].
• Lansoprazole-associated microscopic colitis: a case series [5].
• CONCLUSIONS: A shared set of predisposing HLA-DQ genes account for the epidemiological overlap of celiac sprue and microscopic colitis [6].

Chemical compound and disease context of Colitis, Microscopic

• Use of verapamil for the symptomatic treatment of microscopic colitis [7].
• Bile acid malabsorption in microscopic colitis and in previously unexplained functional chronic diarrhea [8].
• RESULTS: Histological examination of the colon biopsy specimens taken from all nine patients with ticlopidine related chronic diarrhoea showed characteristic features of microscopic colitis [9].
• We studied whether prednisolone could induce remission in patients with disabling, chronic diarrhoea due to microscopic colitis [10].
• Ozone therapy induced microscopic colitis, which lasted for at least a week and was accompanied by increase in segmental weight, myeloperoxidase and nitric oxide activity, and prostaglandin E2 generation [11].

Biological context of Colitis, Microscopic

• Because there are epidemiological and histopathological similarities between celiac sprue and microscopic colitis, we hypothesized that these syndrome may share an HLA genetic predisposition and pathogenesis [6].
• We identified 113 patients with microscopic colitis, and 46 patients underwent a small bowel biopsy and/or celiac serology [12].
• In particular, specific HLA-DQ genotypes may be permissive for the development of microscopic colitis, and suggest a linkage to the pathogenesis of celiac sprue [13].

Gene context of Colitis, Microscopic

• RESULTS: Familial occurrence of microscopic colitis was identified in five families [14].
• Right-sided microscopic colitis is a recently recognized entity in CF of uncertain clinical significance [15].
• METHODS: HLA-DQ2, HLA-DQ8, serum immunoglobulin A-antiendomysial and immunoglobulin A-anti-tissue transglutaminase antibodies were investigated in 59 patients with microscopic colitis [16].

References