Disease relevance of Agelas

• As the result of a structurally guided isolation to identify lead compounds for the treatment of opportunistic infections of AIDS, the dihydrochloride salt of a new symmetrical pyrrole dimer debromosceptrin (1), and two known pyrrole analogues (2 and 3) were isolated from the Caribbean sponge Agelas coniferacollected from Belize [1].

High impact information on Agelas

• Total Synthesis of Ageladine A, an Angiogenesis Inhibitor from the Marine Sponge Agelas nakamurai [2].
• Reinvestigation of the glycosphingolipid composition of the marine sponge Agelas clathrodes revealed the presence of a new tetraglycosylated alpha-galactoglycosphingolipid (1a), containing an unusual l-rhamnose unit in the sugar head [3].
• [reaction: see text] The first enantioselective syntheses of slagenins B and C, marine metabolites from Agelas nakamurai, starting from L-arabinose have been described [4].
• AGL-517 (AGL) has an alpha-galactosylceramide structure and is a derivative of agelasphin-9b, which in turn is isolated from Agelas mauritianus and has immunomodulating activity [5].
• The mechanism of action of sceptrin, an antimicrobial agent isolated from the sponge Agelas mauritiana, was investigated [6].

Biological context of Agelas

• Seven pyrrole alkaloids isolated from Agelas sponges were tested for interactions with the cellular calcium homeostasis [7].

Associations of Agelas with chemical compounds

• 26-Nor-25-isopropyl-ergosta-5,7,22E-trien-3beta-ol: a new C(29) sterol from the sponge Agelas sceptrum from Jamaica [8].
• From a Maltese sample of the marine sponge Agelas oroides, five compounds: oroidin (1), 2-cyano-4,5-dibromopyrrole (2), 4,5-dibromopyrrole-2-carboxylic acid (3), 4,5-dibromopyrrole-2-carboxylic acid methyl ester (4), and 4 alpha-methyl-5 alpha-cholest-8-en-3 beta-ol (5) have been isolated [9].
• Brominated pyrrole alkaloids from marine Agelas sponges reduce depolarization-induced cellular calcium elevation [7].
• As a putative key intermediate, the natural product Nalpha-(4-bromopyrrolyl-2-carbonyl)-L-homoarginine (1) from the sponge Agelas wiedenmayeri was synthesized in the solid phase starting from Fmoc/Pmc-protected L-homoarginine and in solution starting from readily available L-lysine methyl ester [10].
• Agelasines H and I, 9-methyladenine-containing diterpenoids from an Agelas sponge [11].

Gene context of Agelas

• Glycolipids from sponges. Part 17. Clathrosides and isoclathrosides, unique glycolipids from the Caribbean sponge Agelas clathrodes [12].
• A potent actomyosin ATPase activator from the Okinawan marine sponge Agelas cf. nemoechinata [13].

References