Disease relevance of Pancreatic Polypeptide-Secreting Cells

• Insulin, glucagon, somatostatin and pancreatic polypeptide cells were quantified after immunoperoxidase staining in sections of pancreases obtained from nine control subjects and seven diabetic patients with primary or secondary iron overload [1].

High impact information on Pancreatic Polypeptide-Secreting Cells

• At 4 weeks' gestation (the earliest stage studied), glucagon, insulin, and somatostatin cells occurred in the dorsal pancreatic primordium, whereas pancreatic polypeptide cells occurred in the ventral primordium [2].
• In the mammalian pancreas, the endocrine cell types of the islets of Langerhans, including the alpha-, beta-, delta-, and pancreatic polypeptide cells as well as the exocrine cells, derive from foregut endodermal progenitors [3].
• AMPA receptor subunits were expressed in alpha, beta, and pancreatic polypeptide cells, whereas kainate receptors were found predominantly in alpha and delta cells [4].
• The insulin cells formed the core of the islets while the glucagon, the somatostatin and the pancreatic polypeptide cells were located at the periphery [5].
• It was difficult to determine the presence of IAPP in pancreatic polypeptide cells, because they were so seldom seen in this material [6].

Anatomical context of Pancreatic Polypeptide-Secreting Cells

• Qualitatively, the two pancreas were characterized by the lack of segregation of glucagon and pancreatic polypeptide cells to distinct parts of the gland, with each cell type being abundant in the pancreatic region in which they are normally very sparse [7].

Associations of Pancreatic Polypeptide-Secreting Cells with chemical compounds

• While insulin, glucagon, somatostatin, and pancreatic polypeptide cells were widely distributed along the entire duct system, small numbers of cholecystokinin and serotonin cells were confined to the terminal portion [8].

Gene context of Pancreatic Polypeptide-Secreting Cells

• These cells are probably distinct from the pancreatic PP cell type, and the PP-immunoreactive material probably represents the homologous peptide YY rather than PP [9].
• Somatostatin receptor subtype 5 was expressed in most beta and delta cells but almost absent in alpha and pancreatic polypeptide cells [10].
• PP (pancreatic polypeptide) cells were immunostained with antibodies between CgB 1-417 and a few with CgB 580-593 [11].
• Throughout development FA1 was not detected in endocrine glucagon, somatostatin or pancreatic polypeptide cells [12].
• We describe a simple immunohistochemical method for simultaneous demonstration of insulin, glucagon, somatostatin, and pancreatic polypeptide cells of the Langerhans islet in routinely fixed paraffin-embedded human and Syrian hamster pancreases [13].

Analytical, diagnostic and therapeutic context of Pancreatic Polypeptide-Secreting Cells

• Insulin, glucagon, somatostatin and pancreatic polypeptide cells were stained by immunoperoxidase techniques and quantitated morphometrically in sections of pancreases obtained from eight control subjects, four Type 1 (insulin-dependent) and eight Type 2 (non-insulin-dependent) diabetic patients [14].

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