Disease relevance of Elastic Cartilage

• Two cases of elastic cartilage choristoma in the skin and subcutaneous tissues of the lower midline of the neck are reported [1].

High impact information on Elastic Cartilage

• Elastin is a key extracellular matrix protein that is critical to the elasticity and resilience of many vertebrate tissues including large arteries, lung, ligament, tendon, skin, and elastic cartilage [2].
• Following longer periods of androgen treatment (3 weeks), AR mRNA expression is down-regulated and male-typical differentiation of elastic cartilage is induced in both sexes [3].
• We attempted to investigate the potential of conventionally isolated and passaged chondrocytes (2D environment) when seeded and cultured in combination with a biomimetic hydrogel in a mechanically stable and biomimetic composite matrix to form elastic cartilage within ectopic implantation sites [4].
• After 10 weeks a matrix containing elastin was shown by staining with orcein, indicating that an elastic cartilage had been formed [5].
• CONCLUSIONS: Auricular elastic cartilage is a ready and easily accessible source of chondrocytes whose ability to produce collagen II and other important extracellular matrix constituents allows them to adhere strongly to the luminal surfaces of LVADs [6].

Anatomical context of Elastic Cartilage

• The effect of fibroblast growth factor and transforming growth factor-beta on porcine chondrocytes and tissue-engineered autologous elastic cartilage [7].
• Glial fibrillary acidic protein in chondrocytes of elastic cartilage in the human epiglottis: an immunohistochemical study with polyvalent and monoclonal antibodies [8].
• Chondrocytes in hyaline and fibrocartilage do not express GFAP, but in the elastic cartilage of the human epiglottis we found GFAP to be regularly present when tested with either polyclonal or monoclonal antibodies [8].

Associations of Elastic Cartilage with chemical compounds

• Thin sections of glutaraldehyde-fixed, embedded rat aorta and rabbit elastic cartilage, with and without osmication, were examined [9].
• Histological evaluation of the implants using H&E, Safranin O, trichrome blue, and Verhoeff's stains demonstrated findings consistent with mature elastic cartilage [10].
• Hyaluronic acid in elastic cartilage [11].
• The distribution of elastic cartilage in the arytenoids was investigated histologically in two serial sections: horizontal and coronal [12].
• The effect of agarose and dexamethasone on the nature and production of extracellular matrix components by elastic cartilage chondrocytes [13].

Gene context of Elastic Cartilage

• Some of the possible functions of elastin in elastic cartilages are discussed and the possiblity of a new type of elastin perhaps unique to cartilage is suggested [14].
• DDP was not detected in calf ligament, tendon, bone, ocular lens, cornea, or elastic cartilage [15].
• Analyses for collagen, proteoglycans, and elastin were consistent with elastic cartilage [16].
• The results suggest that basic fibroblast growth factor has the potential for clinical application in which a goal will be to generate a large volume of tissue-engineered cartilage from a small donor specimen in a short period of time and of a quality similar to native human elastic cartilage [17].

Analytical, diagnostic and therapeutic context of Elastic Cartilage

• Hematoxylin and eosin, safranine o, trichrome blue, and Verhoeff's stains of the experimental implants showed nodules with the characteristic histologic signs of elastic cartilage [18].

References