Disease relevance of New Guinea

• We undertook prospective treatment and prophylaxis trials of chloroquine in children and adults with vivax malaria living in Irian Jaya (Indonesia New Guinea) [1].
• Enterotoxin was definitively detected only in strains of types A and C. This is the first report where enterotoxin production has been demonstrated in a toxigenic type other than type A. The exterotoxin-positive type C strains were isolated from cases of enteritis necroticans ("pig bel+) in New Guinea [2].
• A genomic-length cDNA clone corresponding to the RNA of dengue virus type 2 (DEN-2) New Guinea C strain (NGC) was constructed in a low copy number vector [3].
• On the first point, EBNA 2 gene typing using specific DNA probes showed that four of ten recently established Kenyan BL cell lines and two of four BL cell lines from New Guinea carried type B virus isolates [4].
• Oligonucleotide fingerprint analyses have been used to characterize the virion 40 S RNA species of the four prototype dengue (DEN) serotype viruses: DEN 1, Hawaiian strain; DEN 2, New Guinea C strain (both insect and mouse brain passaged derivatives); DEN 3, H-87 strain; and DEN 4, H-241 strain [5].

High impact information on New Guinea

• Letter: Carbon monoxide, atherosclerosis, and natives of the highlands of New Guinea [6].
• However, strains from highly A11+ populations in New Guinea carry a lysine-to-threonine mutation at residue 424 that abrogates CTL recognition and binding of the peptide to nascent A11 molecules [7].
• Batrachotoxins are neurotoxic steroidal alkaloids first isolated from a Colombian poison-dart frog and later found in certain passerine birds of New Guinea [8].
• Reduced Y-chromosome, but not mitochondrial DNA, diversity in human populations from West New Guinea [9].
• Essential tremor in Papua, New Guinea [10].

Chemical compound and disease context of New Guinea

• Morphological changes such as loss of cytoplasm, membrane destruction and vacuolar swelling in Aedes albopictus clone C6/36 cells infected with dengue virus 2 (DV-2) New Guinea B strain and incubated at 28 degrees C and 37 degrees C, were observed under electron microscope [11].
• The maturation of dengue virus (type 2, New Guinea B strain; abbreviated Den-2) in cultured mosquito C3/36 cells and Vero cells was studied by immunoelectron microscopy for the first 7 days after cells were infected, assays of the virus were done by the peroxidase-antiperoxidase method [12].

Biological context of New Guinea

• However, similar to genetic drift, KSM has its greatest effect in smaller populations and is most apparent in low-density fission-fusion societies such as the Yanomamo of South America and the Semai of Malaysia, and less salient in higher density, low-mobility populations such as those of the New Guinea Highlands [13].

Associations of New Guinea with chemical compounds

• The relationships among allergen-induced EAR and LAR, early and late BHR, and airway inflammation observed in this new guinea pig model are strikingly similar to those observed in patients with asthma [14].
• Subsequently, rigid atebrin discipline was adopted and the incidence of the disease amongst Australian soldiers in New Guinea during 1945 fell to the lowest levels ever recorded to that time by non-immune troops operating for extended periods in highly endemic malarious areas [15].
• Cholesterol metabolism has been studied in a group of healthy males drawn from a New Guinea highland population whose plasma cholesterol concentration is low by Western standards and does not rise with age [16].
• Short report: the activity of pamaquine, an 8-aminoquinoline drug, against sporozoite-induced infections of Plasmodium vivax (New Guinea strains) [17].
• Occurrence of nivalenol, deoxynivalenol, and zearalenone in imported cereals in Papua, New Guinea [18].

Gene context of New Guinea

• HLA-DRB1 frequencies of non-Austronesian-speaking Gidra in south New Guinea and their genetic affinities with Oceanian populations [19].
• Although the average H content of Melanesian and Caucasian samples did not differ significantly, 10% of O and over 20% of A1 and B bloods from coastal Austronesian speakers had higher H than was found among Caucasians, There is evidence that some non-Austronesian populations in New Guinea have twice this incidence of A1 high H [20].
• Large incursions of the virus in 1995 and 1998 were linked with low-pressure systems that sustained strong northerly winds from New Guinea to the Cape York Peninsula [21].
• This is the first report of HD in the Highlands of New Guinea [22].
• Serum thyroglobulin Tg(RIA) was studied in 161 residents of the Nomane region of New Guinea [23].

Analytical, diagnostic and therapeutic context of New Guinea

• DNA typing of HLA-DRB1 genes was conducted for 192 samples from the Gidra who speak one of the non-Austronesian languages and inhabit the southern lowlands of New Guinea [19].
• SDS-PAGE analysis showed that the virus from Rio de Janeiro expresses NS5 (93.0 kDa), NS3 (66.8 kDa) E (62.4 kDa) and NS1 (41.2 kDa) proteins differently from the New Guinea "C" virus [24].

References