Disease relevance of Vascular Patency

• We hypothesized that hypoxia/ischemia triggers IL-10 production, to dampen proinflammatory cytokine and adhesion receptor cascades and to restore vascular patency by fibrinolytic potentiation [1].
• Effects of vapiprost, a novel thromboxane receptor antagonist, on thrombus formation and vascular patency after thrombolysis by tissue-type plasminogen activator [2].
• Ischemic limbs treated with coenzyme Q10 showed a statistically significant (p < 0.05) improvement in vascular patency after 72 and 96 hours of ischemia [3].

High impact information on Vascular Patency

• Plasminogen supports tumor growth through a fibrinogen-dependent mechanism linked to vascular patency [4].
• The antagonism of this inhibitor by ibuprofen maintains vascular patency [5].
• However, inhibition of prostaglandin synthesis by indomethacin failed to promote vascular patency in burn-injured animals [6].
• Combination of bortezomib and tPA extends the thrombolytic window for stroke to 6 h, which is associated with the improvement of vascular patency and integrity [7].
• Diabetic control was monitored by fasting blood levels and postprandial and intravenous glucose tolerance tests, and vascular patency by the loudness of the bruit [8].

Biological context of Vascular Patency

• In normal hemostasis and with a healthy endothelium, intravascular thrombosis is prevented, and vascular patency is protected by the fibrinolytic system and a number of antithrombotic factors, such as antithrombin, thrombomodulin, and tissue factor pathway inhibitor [9].

Anatomical context of Vascular Patency

• The vascular patency of blood vessels was directly visualized by latex vascular casts made 24 hours after burn [10].

Associations of Vascular Patency with chemical compounds

• Ascorbate improved vascular patency without affecting the PMN content [11].
• Vascular patency was shown by perfused yellow latex casts [12].
• An evaluation of the ability of the peripheral vasodilator buflomedil to improve vascular patency after acute frostbite [13].
• The vascular patency of the pedicle was determined by intravenous injection of fluorescein dye after the second stage of omental extension [14].

Gene context of Vascular Patency

• Evidence indicates that annexin II may be crucial to the efficient generation of cell surface plasmin, endothelial cell formation of new blood vessels, and maintenance of vascular patency [15].
• Vascular patency was markedly increased in both PAI-1- and alpha2-AP-deficient mice [16].

References