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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Femoral Artery

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Disease relevance of Femoral Artery


High impact information on Femoral Artery

  • Adenoviral delivery of a phosphorylation-defective survivin mutant reversed the cytoprotective effect of PDGF in SMCs without affecting mitotic progression, suppressed neointimal formation in wire-injured mouse femoral arteries, and induced vascular cell apoptosis in vivo [6].
  • Because NO is an important regulator of vasomotor tone, we investigated whether Akt can regulate endothelium-dependent vasomotion in vivo using a rabbit femoral artery model of gene transfer [7].
  • Lesions induced by 4 wk of cholesterol feeding after focal desiccation of femoral arteries were balloon dilated [8].
  • N-monomethyl-L-arginine (L-NMMA), a specific inhibitor of NO synthase, was administered directly into the femoral artery of normal subjects at a dose of 16 mg/min and leg blood flow (LBF) was measured during an infusion of saline (NS) or during a euglycemic hyperinsulinemic clamp (HIC) designed to approximately double LBF [9].
  • Samples of blood were obtained simultaneously from right heart and femoral artery, and arteriovenous difference (AVd) in histamine concentration across the bronchus was determined during mast cell degranulation [10].

Chemical compound and disease context of Femoral Artery


Biological context of Femoral Artery


Anatomical context of Femoral Artery


Associations of Femoral Artery with chemical compounds

  • Study 4: subjects were studied as per study 3 except that catheters were inserted into the femoral artery and vein to quantitate leg glucose uptake [26].
  • Femoral-artery blood samples were taken for assay of adrenaline and noradrenaline [27].
  • Treatment of superficial femoral artery occlusions by PTA with rt-PA and intravenous heparin seems to prevent rethrombosis [28].
  • Acetylcholine dilated normal femoral arteries but constricted arteries with endothelial injury [29].
  • CONCLUSIONS: We conclude that a physiological insulin concentration attenuates the 5-HT-induced [Ca2+]i transient in confluent primary cultured canine femoral artery VSMCs by inhibiting the 5-HT-induced component of Ca2+ influx but not by affecting sarcolemmal Ca2+ efflux or Ca2+ release from intracellular stores [30].

Gene context of Femoral Artery

  • In a rabbit femoral artery model, percutaneous delivery of TFPI using a recombinant adenoviral vector resulted in a significant reduction of the intimamedia ratio 21 days after injury [31].
  • In mouse femoral arteries, CCR8 and TCA3 antigen colocalized with VSMCs and were up-regulated after injury [32].
  • One week after perivascular electric injury of the carotid or femoral artery in wild-type (MMP-3+/+) or MMP-3-/- mice, 70 kD and 65 kD proMMP-2 levels were enhanced by twofold to fourfold, with corresponding increases of 20- to 40-fold for active 61 kD and 58 kD MMP-2, and of 10- to 80-fold for 94 kD proMMP-9 [33].
  • No significant differences were found in the values obtained simultaneously from hepatic, renal, and brachial veins or femoral artery, which suggests that no major net production or release of IGFBP-3 or IGF-I occurs in these tissues [34].
  • IGFBP-1 and -3, IGF-I, and GH levels were measured by RIA in hepatic, renal, and peripheral veins and in the femoral artery [34].

Analytical, diagnostic and therapeutic context of Femoral Artery


  1. Tissue inhibitor of matrix metalloproteinases-1 impairs arterial neointima formation after vascular injury in mice. Lijnen, H.R., Soloway, P., Collen, D. Circ. Res. (1999) [Pubmed]
  2. Hypertension, transmural pressure, and vascular smooth muscle response in rats. Hansen, T.R., Bohr, D.F. Circ. Res. (1975) [Pubmed]
  3. Tumor necrosis factor alpha-mediated tumor regression by the in vivo transfer of genes into the artery that leads to tumors. Mizuguchi, H., Nakagawa, T., Toyosawa, S., Nakanishi, M., Imazu, S., Nakanishi, T., Tsutsumi, Y., Nakagawa, S., Hayakawa, T., Ijuhin, N., Mayumi, T. Cancer Res. (1998) [Pubmed]
  4. Significance of ST segment depression during paroxysmal supraventricular tachycardia. Nelson, S.D., Kou, W.H., Annesley, T., de Buitleir, M., Morady, F. J. Am. Coll. Cardiol. (1988) [Pubmed]
  5. Glucocorticoid-regulated VEGF expression in ischemic skeletal muscle. Halaby, I.A., Lyden, S.P., Davies, M.G., Roztocil, E., Salamone, L.J., Brooks, A.I., Green, R.M., Federoff, H.J., Bowers, W.J. Mol. Ther. (2002) [Pubmed]
  6. Inhibitor of apoptosis protein survivin regulates vascular injury. Blanc-Brude, O.P., Yu, J., Simosa, H., Conte, M.S., Sessa, W.C., Altieri, D.C. Nat. Med. (2002) [Pubmed]
  7. Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo. Luo, Z., Fujio, Y., Kureishi, Y., Rudic, R.D., Daumerie, G., Fulton, D., Sessa, W.C., Walsh, K. J. Clin. Invest. (2000) [Pubmed]
  8. Effect of alpha-tocopherol on restenosis after angioplasty in a model of experimental atherosclerosis. Lafont, A.M., Chai, Y.C., Cornhill, J.F., Whitlow, P.L., Howe, P.H., Chisolm, G.M. J. Clin. Invest. (1995) [Pubmed]
  9. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. Steinberg, H.O., Brechtel, G., Johnson, A., Fineberg, N., Baron, A.D. J. Clin. Invest. (1994) [Pubmed]
  10. Sympathetic modulation of biochemical and physiological response to immune degranulation in canine bronchial airways in vivo. Garrity, E.R., Stimler, N.P., Munoz, N.M., Tallet, J., David, A.C., Leff, A.R. J. Clin. Invest. (1985) [Pubmed]
  11. Mouse model of femoral artery denudation injury associated with the rapid accumulation of adhesion molecules on the luminal surface and recruitment of neutrophils. Roque, M., Fallon, J.T., Badimon, J.J., Zhang, W.X., Taubman, M.B., Reis, E.D. Arterioscler. Thromb. Vasc. Biol. (2000) [Pubmed]
  12. Clinical experience with a new nitinol self-expanding stent in peripheral arteries. Henry, M., Amor, M., Beyar, R., Henry, I., Porte, J.M., Mentre, B., Tricoche, O., Ethevenot, G. Journal of endovascular surgery : the official journal of the International Society for Endovascular Surgery. (1996) [Pubmed]
  13. Differential effects of angiotensin II and angiotensin-(1-7) at the nucleus tractus solitarii of transgenic rats with low brain angiotensinogen. Couto, A.S., Baltatu, O., Santos, R.A., Ganten, D., Bader, M., Campagnole-Santos, M.J. J. Hypertens. (2002) [Pubmed]
  14. Hypercholesterolemia aggravates radiocontrast nephrotoxicity: protective role of L-arginine. Andrade, L., Campos, S.B., Seguro, A.C. Kidney Int. (1998) [Pubmed]
  15. Inhibitory effect of a novel orally active GP IIb/IIIa inhibitor, SC-54684A on intimal thickening in the guinea pig femoral artery. Umemura, K., Nishiyama, H., Kikuchi, S., Kondo, K., Nakashima, M. Thromb. Haemost. (1996) [Pubmed]
  16. Combined ADP and thromboxane A2 antagonism prevents cyclic flow variations in stenosed and endothelium-injured arteries in nonhuman primates. Yao, S.K., McNatt, J., Cui, K., Anderson, H.V., Maffrand, J.P., Buja, L.M., Willerson, J.T. Circulation (1993) [Pubmed]
  17. Evidence for a local sympathetic venoarteriolar "reflex" in the dog hindleg. Henriksen, O., Amtorp, O., Faris, I., Agerskov, K. Circ. Res. (1983) [Pubmed]
  18. Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease. Böger, R.H., Bode-Böger, S.M., Thiele, W., Creutzig, A., Alexander, K., Frölich, J.C. J. Am. Coll. Cardiol. (1998) [Pubmed]
  19. Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans. Steensberg, A., Fischer, C.P., Sacchetti, M., Keller, C., Osada, T., Schjerling, P., van Hall, G., Febbraio, M.A., Pedersen, B.K. J. Physiol. (Lond.) (2003) [Pubmed]
  20. Effect of androstenedione administration on the maternal hypothalamo-pituitary-adreno-placental axis in the pregnant rhesus monkey. Giussani, D.A., Jenkins, S.L., Mecenas, C.A., Winter, J.A., Pedro, J.G., Farber, D.M., Goland, R.S., Nathanielsz, P.W. Endocrinology (1996) [Pubmed]
  21. Metabolism of C-peptide in the dog. In vivo demonstration of the absence of hepatic extraction. Polonsky, K., Jaspan, J., Pugh, W., Cohen, D., Schneider, M., Schwartz, T., Moossa, A.R., Tager, H., Rubenstein, A.H. J. Clin. Invest. (1983) [Pubmed]
  22. Hirudin reduces tissue factor expression in neointima after balloon injury in rabbit femoral and porcine coronary arteries. Gertz, S.D., Fallon, J.T., Gallo, R., Taubman, M.B., Banai, S., Barry, W.L., Gimple, L.W., Nemerson, Y., Thiruvikraman, S., Naidu, S.S., Chesebro, J.H., Fuster, V., Sarembock, I.J., Badimon, J.J. Circulation (1998) [Pubmed]
  23. Enhancement of thrombolysis with tissue-type plasminogen activator by pretreatment with heparin. Cercek, B., Lew, A.S., Hod, H., Yano, J., Reddy, N.K., Ganz, W. Circulation (1986) [Pubmed]
  24. Pharmacology of TA-3090 (8-chloro diltiazem) related to its cerebrovascular protective properties. Bevan, J.A., Kaminow, L., Laher, I., Thompson, L.P. Circulation (1989) [Pubmed]
  25. Phorbol dibutyrate stimulates the release of diffusible endothelium-derived vasoconstrictor factor(s) from canine femoral arteries. Rubanyi, G.M., Luisi, A., Johns, A. Circ. Res. (1991) [Pubmed]
  26. Synergistic interaction between exercise and insulin on peripheral glucose uptake. DeFronzo, R.A., Ferrannini, E., Sato, Y., Felig, P., Wahren, J. J. Clin. Invest. (1981) [Pubmed]
  27. Comparison of endotracheal and peripheral intravenous adrenaline in cardiac arrest. Is the endotracheal route reliable? Quinton, D.N., O'Byrne, G., Aitkenhead, A.R. Lancet (1987) [Pubmed]
  28. Femoral artery recanalisation with percutaneous angioplasty and segmentally enclosed plasminogen activator. Jørgensen, B., Tønnesen, K.H., Bülow, J., Nielsen, J.D., Jørgensen, M., Holstein, P., Andersen, E. Lancet (1989) [Pubmed]
  29. Endogenous nitric oxide protects against platelet aggregation and cyclic flow variations in stenosed and endothelium-injured arteries. Yao, S.K., Ober, J.C., Krishnaswami, A., Ferguson, J.J., Anderson, H.V., Golino, P., Buja, L.M., Willerson, J.T. Circulation (1992) [Pubmed]
  30. Insulin inhibits serotonin-induced Ca2+ influx in vascular smooth muscle. Kahn, A.M., Allen, J.C., Seidel, C.L., Song, T. Circulation (1994) [Pubmed]
  31. Inhibition of restenosis by tissue factor pathway inhibitor: in vivo and in vitro evidence for suppressed monocyte chemoattraction and reduced gelatinolytic activity. Kopp, C.W., Hölzenbein, T., Steiner, S., Marculescu, R., Bergmeister, H., Seidinger, D., Mosberger, I., Kaun, C., Cejna, M., Horvat, R., Wojta, J., Maurer, G., Binder, B.R., Breuss, J.M., Ecker, R.C., de Martin, R., Minar, E. Blood (2004) [Pubmed]
  32. Chemokine receptor-8 (CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion. Haque, N.S., Fallon, J.T., Pan, J.J., Taubman, M.B., Harpel, P.C. Blood (2004) [Pubmed]
  33. Stromelysin-1 (MMP-3)-independent gelatinase expression and activation in mice. Lijnen, H.R., Silence, J., Van Hoef, B., Collen, D. Blood (1998) [Pubmed]
  34. Concentrations, release, and disposal of insulin-like growth factor (IGF)-binding proteins (IGFBP), IGF-I, and growth hormone in different vascular beds in patients with cirrhosis. Møller, S., Juul, A., Becker, U., Flyvbjerg, A., Skakkebaek, N.E., Henriksen, J.H. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  35. Paired comparison of vascular wall reactions to Palmaz stents, Strecker tantalum stents, and Wallstents in canine iliac and femoral arteries. Barth, K.H., Virmani, R., Froelich, J., Takeda, T., Lossef, S.V., Newsome, J., Jones, R., Lindisch, D. Circulation (1996) [Pubmed]
  36. Geometric remodeling is not the principal pathogenetic process in restenosis after balloon angioplasty. Evidence from correlative angiographic-histomorphometric studies of atherosclerotic arteries in rabbits. Gertz, S.D., Gimple, L.W., Banai, S., Ragosta, M., Powers, E.R., Roberts, W.C., Perez, L.S., Sarembock, I.J. Circulation (1994) [Pubmed]
  37. Inhibition of vascular smooth muscle cell proliferation and neointimal accumulation by adenovirus-mediated gene transfer of cytosine deaminase. Harrell, R.L., Rajanayagam, S., Doanes, A.M., Guzman, R.J., Hirschowitz, E.A., Crystal, R.G., Epstein, S.E., Finkel, T. Circulation (1997) [Pubmed]
  38. Heparin increases exercise-induced collateral blood flow in rats with femoral artery ligation. Yang, H.T., Ogilvie, R.W., Terjung, R.L. Circ. Res. (1995) [Pubmed]
  39. Restenosis after experimental angioplasty. Intimal, medial, and adventitial changes associated with constrictive remodeling. Lafont, A., Guzman, L.A., Whitlow, P.L., Goormastic, M., Cornhill, J.F., Chisolm, G.M. Circ. Res. (1995) [Pubmed]
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