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Disease relevance of Blastomycosis


High impact information on Blastomycosis

  • Cloned cDNA was used to express a 30-kD fusion protein strongly recognized in western blots by rabbit anti-WI-1 antiserum, and by sera from all 35 blastomycosis patients studied [5].
  • Initial therapy with amphotericin B is appropriate in patients with AIDS and presumptive blastomycosis [6].
  • RESULTS: Twelve of 15 patients had a previous or concomitant AIDS-defining illness at the time of diagnosis of blastomycosis, and only one patient had a CD4 lymphocyte count of greater than 200 cells/mm3 [6].
  • Ketoconazole therapy for endemic blastomycosis [7].
  • In contrast to these findings, neutralization of elevated TGF-beta levels during experimental pulmonary blastomycosis did not restore BAD1-suppressed TNF-alpha levels in the lung or ameliorate disease [8].

Chemical compound and disease context of Blastomycosis


Biological context of Blastomycosis


Anatomical context of Blastomycosis


Gene context of Blastomycosis


Analytical, diagnostic and therapeutic context of Blastomycosis


  1. Itraconazole therapy for blastomycosis and histoplasmosis. NIAID Mycoses Study Group. Dismukes, W.E., Bradsher, R.W., Cloud, G.C., Kauffman, C.A., Chapman, S.W., George, R.B., Stevens, D.A., Girard, W.M., Saag, M.S., Bowles-Patton, C. Am. J. Med. (1992) [Pubmed]
  2. Acute miliary blastomycosis after 'short-course' corticosteroid treatment. Berger, R., Kraman, S. Arch. Intern. Med. (1981) [Pubmed]
  3. Intravenous miconazole therapy of mycotic infections. Wade, T.R., Jones, H.E., Chanda, J.J. Arch. Intern. Med. (1979) [Pubmed]
  4. Therapeutic effect of the triazole Bay R 3783 in mouse models of coccidioidomycosis, blastomycosis, and histoplasmosis. Pappagianis, D., Zimmer, B.L., Theodoropoulos, G., Plempel, M., Hector, R.F. Antimicrob. Agents Chemother. (1990) [Pubmed]
  5. Immunologic recognition of a 25-amino acid repeat arrayed in tandem on a major antigen of Blastomyces dermatitidis. Klein, B.S., Hogan, L.H., Jones, J.M. J. Clin. Invest. (1993) [Pubmed]
  6. Blastomycosis in patients with the acquired immunodeficiency syndrome. Pappas, P.G., Pottage, J.C., Powderly, W.G., Fraser, V.J., Stratton, C.W., McKenzie, S., Tapper, M.L., Chmel, H., Bonebrake, F.C., Blum, R. Ann. Intern. Med. (1992) [Pubmed]
  7. Ketoconazole therapy for endemic blastomycosis. Bradsher, R.W., Rice, D.C., Abernathy, R.S. Ann. Intern. Med. (1985) [Pubmed]
  8. BAD1, an essential virulence factor of Blastomyces dermatitidis, suppresses host TNF-alpha production through TGF-beta-dependent and -independent mechanisms. Finkel-Jimenez, B., Wüthrich, M., Klein, B.S. J. Immunol. (2002) [Pubmed]
  9. Blastomycosis presenting as monoarticular arthritis. The role of synovial fluid cytology. George, A.L., Hays, J.T., Graham, B.S. Arthritis Rheum. (1985) [Pubmed]
  10. SCH 39304 in the treatment of acute or established murine pulmonary blastomycosis. Brummer, E., Hanson, L.H., Stevens, D.A. Antimicrob. Agents Chemother. (1991) [Pubmed]
  11. Treatment of murine pulmonary blastomycosis with SCH 51048, a broad-spectrum triazole antifungal agent. Sugar, A.M., Picard, M. Antimicrob. Agents Chemother. (1995) [Pubmed]
  12. Role of glucan and surface protein BAD1 in complement activation by Blastomyces dermatitidis yeast. Zhang, M.X., Brandhorst, T.T., Kozel, T.R., Klein, B.S. Infect. Immun. (2001) [Pubmed]
  13. Utility of anti-WI-1 serological testing in the diagnosis of blastomycosis in Wisconsin residents. Soufleris, A.J., Klein, B.S., Courtney, B.T., Proctor, M.E., Jones, J.M. Clin. Infect. Dis. (1994) [Pubmed]
  14. Blastomycosis in the immunocompromised patient. Pappas, P.G. Seminars in respiratory infections. (1997) [Pubmed]
  15. Synergy of itraconazole with macrophages in killing Blastomyces dermatitidis. Brummer, E., Bhagavathula, P.R., Hanson, L.H., Stevens, D.A. Antimicrob. Agents Chemother. (1992) [Pubmed]
  16. Recurrent central nervous system blastomycosis in an immunocompetent child treated successfully with sequential liposomal amphotericin B and voriconazole. Panicker, J., Walsh, T., Kamani, N. Pediatr. Infect. Dis. J. (2006) [Pubmed]
  17. Lymphocyte subpopulations of blood and alveolar lavage in blastomycosis. Jacobs, R.F., Marmer, D.J., Balk, R.A., Bradsher, R.W. Chest (1985) [Pubmed]
  18. Treatment of murine pulmonary blastomycosis with SCH 39304, a new triazole antifungal agent. Sugar, A.M., Picard, M., Noble, L. Antimicrob. Agents Chemother. (1990) [Pubmed]
  19. Evaluation of nikkomycins X and Z in murine models of coccidioidomycosis, histoplasmosis, and blastomycosis. Hector, R.F., Zimmer, B.L., Pappagianis, D. Antimicrob. Agents Chemother. (1990) [Pubmed]
  20. Mapping of a Coccidioides immitis-specific epitope that reacts with complement-fixing antibody. Yang, M.C., Magee, D.M., Cox, R.A. Infect. Immun. (1997) [Pubmed]
  21. A laboratory-based surveillance of human blastomycosis in Wisconsin between 1973 and 1982. Klein, B.S., Davis, J.P. Am. J. Epidemiol. (1985) [Pubmed]
  22. Delayed diagnosis of osseous blastomycosis in two patients following environmental exposure in nonendemic areas. Veligandla, S.R., Hinrichs, S.H., Rupp, M.E., Lien, E.A., Neff, J.R., Iwen, P.C. Am. J. Clin. Pathol. (2002) [Pubmed]
  23. Preparation of reference antisera for laboratory diagnosis of blastomycosis. Green, J.H., Harrell, W.K., Johnson, J.E., Benson, R. J. Clin. Microbiol. (1979) [Pubmed]
  24. Successful treatment of systemic blastomycosis with high-dose ketoconazole in a renal transplant recipient. Hii, J.H., Legault, L., DeVeber, G., Vas, S.I. Am. J. Kidney Dis. (1990) [Pubmed]
  25. Comparative evaluation of commercial Premier EIA and microimmunodiffusion and complement fixation tests for Coccidioides immitis antibodies. Kaufman, L., Sekhon, A.S., Moledina, N., Jalbert, M., Pappagianis, D. J. Clin. Microbiol. (1995) [Pubmed]
  26. Apparent diminution of the blastomycin skin test; follow-up of an epidemic of blastomycosis. Sarosi, G.A., King, R.A. Am. Rev. Respir. Dis. (1977) [Pubmed]
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