Disease relevance of Chemistry, Physical

• An understanding of the physical chemistry of cholesterol and UCB, both as solubilized in bile and as precipitated in gallstones, is basic to an understanding of the pathogenesis of gallstone disease, as well as current and potential chemical methods of gallstone dissolution and prevention [1].
• An intensive programme of work exploring the biology, toxicity and physical chemistry of a novel series of inhibitors, derived from RPR132331, has led to the identification of RPR200765A, a development candidate for the treatment of rheumatoid arthritis (RA) [2].
• Single and multiple turnover reactions in the ubiquinone-cytochrome b-c2 oxidoreductase of Rhodopseudomonas sphaeroids: the physical chemistry of the major electron donor to cytochrome c2, and its coupled reactions [3].

High impact information on Chemistry, Physical

• The physical chemistry of cholesterol solubility in bile. Relationship to gallstone formation and dissolution in man [4].
• We explore the physical chemistry of three such systems: an organic monomer (alpha-methylstyrene), an inorganic monomer (sulfur), and a biopolymer (actin) [5].
• Using physical chemistry to differentiate nicotinic from cholinergic agonists at the nicotinic acetylcholine receptor [6].
• The physical chemistry and the free radical chemistry of the most abundant polyphenolic flavan-3-ols in food, catechin, its methylated metabolites, and several methylated analogues, have been investigated by laser flash photolysis and cyclic voltammetry studies [7].
• After a discussion of the physical chemistry of nitrogen monoxide, such as solubility (1.55 mM at 37 degrees C and an ionic strength of 0.15 M) and diffusion constant (4.8 x 10(-5) cm2s(-1)), several reactions that can acts as sinks are discussed, namely the reaction with dioxygen, with thiols and with superoxide [8].

Biological context of Chemistry, Physical

• The broad outlines of the physical chemistry of cholesterol solubilization are well understood, but minor components of native biles probably alter the equilibrium solubility of cholesterol in bile and, more importantly, profoundly affect the kinetics of cholesterol crystal formation [1].
• The neurobiology of lithium. III. Physical chemistry and transport. Monovalent cation activation of enzymes [9].

Anatomical context of Chemistry, Physical

• Our ability to recreate the shear threshold effect in a cell-free system strongly suggests the origin of the effect is in the physical chemistry of L-selectin interaction with its ligand, and largely eliminates cellular features such as deformability or topography as its cause [10].
• The physical chemistry of water at nanometre dimensions was used to explain the conformational changes and water breaking properties of the glucose transporter protein (GLUTI) in human erythrocytes more than ten years ago [11].

Associations of Chemistry, Physical with chemical compounds

• Layer by layer buildup of polysaccharide films: physical chemistry and cellular adhesion aspects [12].
• Physical-chemistry characteristics and biodistribution of poly(ethylene glycol)-coated liposomes using poly(oxyethylene) cholesteryl ether [13].
• Physical chemistry of nanostructured molecular sieves by the study of phase diagrams: the case of the cetyltrimethylammonium bromide-tetramethylammonium silicate-water system [14].
• These in vitro experiments shed light on the complex physical chemistry of transport of cholesteryl ester and triolein between HDL and TG-rich lipoproteins which occurs during the metabolism of chylomicrons in plasma [15].

Gene context of Chemistry, Physical

• This definition of the physical chemistry of lithogenesis should aid in further elucidation of the Lith genes and the proteins they encode [16].
• There is a considerable amount of information concerning the spatial and temporal localization of B-50 (GAP-43) in adult, fetal, and regenerating nervous tissue but far less is known about the physical chemistry and biochemistry of the protein [17].
• Solubilities of pesticide chemicals in water. Part I: Environmental physical chemistry [18].
• The method uses properties of extracellular matrix proteins to predict the structure and physical chemistry of the elements that make up the tissue [19].

References