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MeSH Review:

Nelson Syndrome

Jane, J.A. et al., Swain, J.M. et al., Scheithauer, B.W. et al., Shekarriz, M. et al.

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Disease relevance of Nelson Syndrome

Biochemical remission occurred in 36% of patients with GH-secreting adenomas, 73% of those with Cushing disease, 14% of those with Nelson syndrome, and 11% of those harboring prolactinomas [1].

High impact information on Nelson Syndrome

No patient had elevated ACTH levels, and following curative bilateral adrenalectomy, no patient subsequently developed Nelson syndrome, with follow-up ranging from 1 to 8.5 years [2].
Excessive testosterone production in a patient with Nelson syndrome and bilateral testicular tumors [3].

Gene context of Nelson Syndrome

The patients with the ACTH-producing tumors had all presented with Cushing's disease and two of them had undergone adrenalectomy (Nelson syndrome) [4].

References

Stereotactic radiosurgery for hypersecreting pituitary tumors: part of a multimodality approach. Jane, J.A., Vance, M.L., Woodburn, C.J., Laws, E.R. Neurosurgical focus [electronic resource]. (2003) [Pubmed]
Corticotropin-independent macronodular adrenal hyperplasia: a clinicopathologic correlation. Swain, J.M., Grant, C.S., Schlinkert, R.T., Thompson, G.B., vanHeerden, J.A., Lloyd, R.V., Young, W.F. Archives of surgery (Chicago, Ill. : 1960) (1998) [Pubmed]
Excessive testosterone production in a patient with Nelson syndrome and bilateral testicular tumors. Shekarriz, M., Schneider, C., Sabanegh, E., Kempter, F., Waldherr, R. Urologia internationalis. (1996) [Pubmed]
Pituitary carcinoma: an ultrastructural study of eleven cases. Scheithauer, B.W., Fereidooni, F., Horvath, E., Kovacs, K., Robbins, P., Tews, D., Henry, K., Pernicone, P., Gaffrey, T.A., Meyer, F.B., Young, W.F., Fahlbusch, R., Buchfelder, M., Lloyd, R.V. Ultrastructural pathology. (2001) [Pubmed]

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